Výsledky vyhledávání - "Sandrine Jacquoilleot"

Combination of Electrochemistry and Nuclear Magnetic Resonance Spectroscopy for Metabolism Studies

Autor: Sandrine Jacquoilleot, Paul Sanderson, Uwe Karst, Raniero Zazzeroni, Daniel Melles, Hannah Simon

Publikováno v: Analytical Chemistry. 84:8777-8782

During the development of new materials demonstrating biological activity, prediction and identification of reactive intermediates generated in the course of drug metabolism in the human liver is of great importance. We present a rapid and purely ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d92717c6e06ae53b0596cd2891a809b
https://doi.org/10.1021/ac302152a

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Application of Liquid Chromatography-Direct-Electron Ionization-MS in an in Vitro Dermal Absorption Study: Quantitative Determination of trans-Cinnamaldehyde

Autor: Ouarda Saib, Veronica Termopoli, Helga Trufelli, Giorgio Famiglini, Lucia Radici, Achille Cappiello, Raniero Zazzeroni, Sandrine Jacquoilleot

Publikováno v: Analytical Chemistry. 83:8537-8542

We propose a new analytical approach, based on liquid chromatography (LC) coupled to electron ionization mass spectrometry (EI-MS), using a Direct-EI interface, for dermal absorption evaluation studies. Penetration through the skin of a given compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230611c2337f7fc8da4eb12b63a14bdd
https://doi.org/10.1021/ac201839x

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Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin

Autor: Adedamola Olayanju, Neil R. Kitteringham, Maja Aleksic, Dean J. Naisbitt, David Sheffield, Sandrine Jacquoilleot, Rowena Sison-Young

Publikováno v: Toxicology letters. 237(1)

Glutathione (GSH) is the most prominent antioxidant in cells and the co-factor of an important set of enzymes involved in the skin metabolic clearance system, glutathione S-transferases (GST). Here, we describe an LC-MS (liquid chromatography-mass sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4fbd21ef35be2a004c3155038a4002
https://pubmed.ncbi.nlm.nih.gov/26022718

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Applying the skin sensitisation adverse outcome pathway (AOP) to quantitative risk assessment

Autor: Vicki Summerfield, Ruth Pendlington, Richard Stark, Ouarda Saib, Richard Cubberley, Michael Davies, David Sheffield, Sandrine Jacquoilleot, Cameron MacKay, Craig Moore, Gavin Maxwell, Nichola Gellatly, Stephen Glavin, Todd Gouin

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 28(1)

As documented in the recent OECD report 'the adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins' (OECD, 2012), the chemical and biological events driving the induction of human skin sensitisation have been invest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc758f6a600b0878326c081980024bfb
https://pubmed.ncbi.nlm.nih.gov/24184331

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Applying the skin sensitisation AOP to human health risk assessment

Autor: Vicki Summerfield, David Sheffield, Sandrine Jacquoilleot, Cameron MacKay, Seraya Dhadra, Richard Cubberley, Gavin Maxwell, Nichola Gellatly, Ruth Pendlington, Juliette Pickles, Ouarda Saib, Craig Moore, Richard Stark

Publikováno v: Toxicology Letters. 229:S10-S11

GAVIN MAXWELL, CATHERINE CLAPP, RICHARD CUBBERLEY, SERAYA DHADRA, NIKKI GELLATLY, STEPHEN GLAVIN, SARAH HADFIELD, SANDRINE JACQUOILLEOT, AMELIA JARMAN, IAN JOWSEY, SUE LOVELL, JACK MAYNE, CRAIG MOORE, RUTH PENDLINGTON, JULIETTE PICKLES, JOE REYNOLDS.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::82f8b6840d9bf8fa85dfd24c12bd5825
https://doi.org/10.1016/j.toxlet.2014.06.066

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