Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Sandrine Imbeaud"'
Autor:
Tiziana La Bella, Bérangère Bertin, Ante Mihaljevic, Justine Nozi, Patrice Vidal, Sandrine Imbeaud, Jean-Charles Nault, Jessica Zucman-Rossi, Giuseppe Ronzitti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101327- (2024)
Adeno-associated virus (AAV) is the most widely used vector for in vivo gene transfer. A major limitation of capsid engineering is the incomplete understanding of the consequences of multiple amino acid variations on AAV capsid stability resulting in
Externí odkaz:
https://doaj.org/article/4eb4a64865374c90a1f8bbb3efe3c1b0
Autor:
Amélie Roehrig, Theo Z. Hirsch, Aurore Pire, Guillaume Morcrette, Barkha Gupta, Charles Marcaillou, Sandrine Imbeaud, Christophe Chardot, Emmanuel Gonzales, Emmanuel Jacquemin, Masahiro Sekiguchi, Junko Takita, Genta Nagae, Eiso Hiyama, Florent Guérin, Monique Fabre, Isabelle Aerts, Sophie Taque, Véronique Laithier, Sophie Branchereau, Catherine Guettier, Laurence Brugières, Brice Fresneau, Jessica Zucman-Rossi, Eric Letouzé
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Hepatoblastomas (HB) display heterogeneous cellular phenotypes that influence the clinical outcome, but the underlying mechanisms are poorly understood. Here, we use a single-cell multiomic strategy to unravel the molecular determinants of t
Externí odkaz:
https://doaj.org/article/14c4d115a5e440889f8a8405c0ba7b92
Autor:
Lisa Quetel, Clément Meiller, Jean‐Baptiste Assié, Yuna Blum, Sandrine Imbeaud, François Montagne, Robin Tranchant, Julien deWolf, Stefano Caruso, Marie‐Christine Copin, Véronique Hofman, Laure Gibault, Cécile Badoual, Ecaterina Pintilie, Paul Hofman, Isabelle Monnet, Arnaud Scherpereel, Françoise Le Pimpec‐Barthes, Jessica Zucman‐Rossi, Marie‐Claude Jaurand, Didier Jean
Publikováno v:
Molecular Oncology, Vol 14, Iss 6, Pp 1207-1223 (2020)
Development of precision medicine for malignant pleural mesothelioma (MPM) requires a deep knowledge of tumor heterogeneity. Histologic and molecular classifications and histo‐molecular gradients have been proposed to describe heterogeneity, but a
Externí odkaz:
https://doaj.org/article/69f3c9f25b93468ea781ad245bb37fda
Autor:
Blandine Monel, Delphine Planas, Ludivine Grzelak, Nikaïa Smith, Nicolas Robillard, Isabelle Staropoli, Pedro Goncalves, Françoise Porrot, Florence Guivel-Benhassine, Nathalie Demory Guinet, Julien Rodary, Julien Puech, Victor Euzen, Laurent Bélec, Galdric Orvoen, Léa Nunes, Véronique Moulin, Jacques Fourgeaud, Maxime Wack, Sandrine Imbeaud, Pascal Campagne, Darragh Duffy, James P. Di Santo, Timothée Bruel, Hélène Péré, David Veyer, Olivier Schwartz
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103637- (2021)
Background: The dynamics of SARS-CoV-2 alpha variant shedding and immune responses at the nasal mucosa remain poorly characterised. Methods: We measured infectious viral release, antibodies and cytokines in 426 PCR+ nasopharyngeal swabs from individu
Externí odkaz:
https://doaj.org/article/844ad9fb1a224552bbc5b70f8dd89d23
Autor:
Quentin Bayard, Léa Meunier, Camille Peneau, Victor Renault, Jayendra Shinde, Jean-Charles Nault, Iadh Mami, Gabrielle Couchy, Giuliana Amaddeo, Emmanuel Tubacher, Delphine Bacq, Vincent Meyer, Tiziana La Bella, Audrey Debaillon-Vesque, Paulette Bioulac-Sage, Olivier Seror, Jean-Frédéric Blanc, Julien Calderaro, Jean-François Deleuze, Sandrine Imbeaud, Jessica Zucman-Rossi, Eric Letouzé
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Cyclins A2 and E1 are known to regulate the cell cycle by promoting S phase entry and progression. Here, they identify an aggressive hepatocellular carcinoma subgroup exhibiting cyclin activation through various mechanisms and find this subgroup to d
Externí odkaz:
https://doaj.org/article/d1c71c5d3832437783153fd87d02ea45
Autor:
Lucie Larigot, Linh-Chi Bui, Marine de Bouvier, Ophélie Pierre, Grégory Pinon, Justine Fiocca, Mohammad Ozeir, Cendrine Tourette, Chris Ottolenghi, Sandrine Imbeaud, Clément Pontoizeau, Benjamin J. Blaise, Aline Chevallier, Céline Tomkiewicz, Béatrice Legrand, Bénédicte Elena-Herrmann, Christian Néri, Vanessa Brinkmann, Pierre Nioche, Robert Barouki, Natascia Ventura, Julien Dairou, Xavier Coumoul
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 1030 (2022)
The Aryl hydrocarbon Receptor (AhR) is a xenobiotic sensor in vertebrates, regulating the metabolism of its own ligands. However, no ligand has been identified to date for any AhR in invertebrates. In C. elegans, the AhR ortholog, AHR-1, displays phy
Externí odkaz:
https://doaj.org/article/a7afe96c2f2c47ebb3100b7366418ee8
Autor:
Eric Letouzé, Jayendra Shinde, Victor Renault, Gabrielle Couchy, Jean-Frédéric Blanc, Emmanuel Tubacher, Quentin Bayard, Delphine Bacq, Vincent Meyer, Jérémy Semhoun, Paulette Bioulac-Sage, Sophie Prévôt, Daniel Azoulay, Valérie Paradis, Sandrine Imbeaud, Jean-François Deleuze, Jessica Zucman-Rossi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Tumorigenesis is a complex process driven by numerous risk factors. Here, genomic analysis of liver cancer reveals the evolution of mutational signatures during tumor development, highlighting mutational and structural signatures linked to environmen
Externí odkaz:
https://doaj.org/article/a2db6282c9e94e1b953a8aca7a20d3f7
Autor:
Guillaume Morcrette, Theo Z Hirsch, Elise Badour, Jill Pilet, Stefano Caruso, Julien Calderaro, Yoann Martin, Sandrine Imbeaud, Eric Letouzé, Sandra Rebouissou, Sophie Branchereau, Sophie Taque, Christophe Chardot, Catherine Guettier, Jean-Yves Scoazec, Monique Fabre, Laurence Brugières, Jessica Zucman-Rossi
Publikováno v:
OncoImmunology, Vol 8, Iss 6 (2019)
Hepatoblastoma (HB) is the most common liver cancer in children. We aimed to characterize HB related to APC (Adenomatous Polyposis Coli) germline mutation (APC-HB). This French multicentric retrospective study included 12 APC-HB patients under 5 at d
Externí odkaz:
https://doaj.org/article/76d10b2eed8042af9fde5d21abf7f106
Autor:
Victor Renault, Jörg Tost, Fabien Pichon, Shu-Fang Wang-Renault, Eric Letouzé, Sandrine Imbeaud, Jessica Zucman-Rossi, Jean-François Deleuze, Alexandre How-Kit
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189334 (2017)
Copy number variations (CNV) include net gains or losses of part or whole chromosomal regions. They differ from copy neutral loss of heterozygosity (cn-LOH) events which do not induce any net change in the copy number and are often associated with un
Externí odkaz:
https://doaj.org/article/87a5d43bfbe34927959c812e20c8d246
Autor:
Nataliya Petryk, You-Fang Zhou, Kateryna Sybirna, Marie-Hélène Mucchielli, Bernard Guiard, Wei-Guo Bao, Oleh V Stasyk, Olena G Stasyk, Olena S Krasovska, Karine Budin, Nancie Reymond, Sandrine Imbeaud, Sophie Coudouel, Hervé Delacroix, Andriy Sibirny, Monique Bolotin-Fukuhara
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e112263 (2014)
The transcriptional regulator HAP4, induced by respiratory substrates, is involved in the balance between fermentation and respiration in S. cerevisiae. We identified putative orthologues of the Hap4 protein in all ascomycetes, based only on a conser
Externí odkaz:
https://doaj.org/article/45b2907153a54bd8ac3c68fdc058afcd