Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Sandrine Humbert"'
Autor:
Hyeongju Kim, Sophie Lenoir, Angela Helfricht, Taeyang Jung, Zhana K. Karneva, Yejin Lee, Wouter Beumer, Geert B. van der Horst, Herma Anthonijsz, Levi C.M. Buil, Frits van der Ham, Gerard J. Platenburg, Pasi Purhonen, Hans Hebert, Sandrine Humbert, Frédéric Saudou, Pontus Klein, Ji-Joon Song
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Huntington’s disease (HD) is a late-onset neurological disorder for which therapeutics are not available. Its key pathological mechanism involves the proteolysis of polyglutamine-expanded (polyQ-expanded) mutant huntingtin (mHTT), which generates N
Externí odkaz:
https://doaj.org/article/4386a98caf404dd9a84e53f674710b00
Autor:
Radhia Kacher, François-Xavier Lejeune, Sandrine Noël, Cécile Cazeneuve, Alexis Brice, Sandrine Humbert, Alexandra Durr
Publikováno v:
eLife, Vol 10 (2021)
Recent work on Huntington disease (HD) suggests that somatic instability of CAG repeat tracts, which can expand into the hundreds in neurons, explains clinical outcomes better than the length of the inherited allele. Here, we measured somatic expansi
Externí odkaz:
https://doaj.org/article/7bcf77ccfd624082ac684348b7e119d4
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100382- (2021)
Summary: BDNF levels are reduced in the chronically stressed brain, in the area of hippocampus. Part of the hippocampal BDNF is provided by neuronal projection of the entorhinal cortex. Studying the cortico-hippocampal transport of BDNF in vivo is te
Externí odkaz:
https://doaj.org/article/3c31f6cd5709418db5f937e5eeb931e1
Autor:
Julie Bruyère, Yah-Se Abada, Hélène Vitet, Gaëlle Fontaine, Jean-Christophe Deloulme, Aurélia Cès, Eric Denarier, Karin Pernet-Gallay, Annie Andrieux, Sandrine Humbert, Marie-Claude Potier, Benoît Delatour, Frédéric Saudou
Publikováno v:
eLife, Vol 9 (2020)
Studies have suggested that amyloid precursor protein (APP) regulates synaptic homeostasis, but the evidence has not been consistent. In particular, signaling pathways controlling APP transport to the synapse in axons and dendrites remain to be ident
Externí odkaz:
https://doaj.org/article/b038de28dd5a440288feebeb14342e19
Autor:
Salah Elias, Morgane S. Thion, Hua Yu, Cristovao Marques Sousa, Charlène Lasgi, Xavier Morin, Sandrine Humbert
Publikováno v:
Stem Cell Reports, Vol 2, Iss 4, Pp 491-506 (2014)
Little is known about the mechanisms of mitotic spindle orientation during mammary gland morphogenesis. Here, we report the presence of huntingtin, the protein mutated in Huntington’s disease, in mouse mammary basal and luminal cells throughout mam
Externí odkaz:
https://doaj.org/article/1db59870e1bf423799bae429d1972893
Autor:
Carla Lopes, Sophie Aubert, Fany Bourgois-Rocha, Monia Barnat, Ana Cristina Rego, Nicole Déglon, Anselme L Perrier, Sandrine Humbert
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148680 (2016)
Mutations of the huntingtin protein (HTT) gene underlie both adult-onset and juvenile forms of Huntington's disease (HD). HTT modulates mitotic spindle orientation and cell fate in mouse cortical progenitors from the ventricular zone. Using human emb
Externí odkaz:
https://doaj.org/article/804b5ee049234073876b67a25959889b
Autor:
David Vallerand, Gérald Massonnet, Fatima Kébir, David Gentien, Zofia Maciorowski, Pierre De la Grange, Brigitte Sigal-Zafrani, Marion Richardson, Sandrine Humbert, Aurélie Thuleau, Franck Assayag, Ludmilla de Plater, André Nicolas, Suzy Scholl, Elisabetta Marangoni, Stefan Weigand, Sergio Roman-Roman, Ariel Savina, Didier Decaudin
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0157670 (2016)
Drug discovery efforts have focused on the tumor microenvironment in recent years. However, few studies have characterized the stroma component in patient-derived xenografts (PDXs) and genetically engineered mouse models (GEMs). In this study, we cha
Externí odkaz:
https://doaj.org/article/b13bb734dbd24545a1d6569df5464d20
Publikováno v:
PLoS Biology, Vol 13, Iss 5, p e1002142 (2015)
The establishment of apical-basolateral polarity is important for both normal development and disease, for example, during tumorigenesis and metastasis. During this process, polarity complexes are targeted to the apical surface by a RAB11A-dependent
Externí odkaz:
https://doaj.org/article/d81a1268e32a43f798975c771fda1f03
Autor:
Patrick Pla, Sophie Orvoen, Caroline Benstaali, Sophie Dodier, Alain M Gardier, Denis J David, Sandrine Humbert, Frédéric Saudou
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73902 (2013)
Huntington's disease (HD) is a fatal neurodegenerative disease, characterized by motor defects and psychiatric symptoms, including mood disorders such as anxiety and depression. HD is caused by an abnormal polyglutamine (polyQ) expansion in the hunti
Externí odkaz:
https://doaj.org/article/158554fc9f0d44feaa605264a9f2a5d4
Publikováno v:
médecine/sciences. 39:313-316
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1335a6e73cd84d5c27352d6d279ef34a
https://doi.org/10.1051/medsci/2023036
https://doi.org/10.1051/medsci/2023036