Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Autor: Xiaodi Yu, Pravien Abeywickrema, Brecht Bonneux, Ishani Behera, Brandon Anson, Edgar Jacoby, Amy Fung, Suraj Adhikary, Anusarka Bhaumik, Rodrigo J. Carbajo, Suzanne De Bruyn, Robyn Miller, Aaron Patrick, Quyen Pham, Madison Piassek, Nick Verheyen, Afzaal Shareef, Priscila Sutto-Ortiz, Nina Ysebaert, Herman Van Vlijmen, Tim H. M. Jonckers, Florence Herschke, Jason S. McLellan, Etienne Decroly, Rachel Fearns, Sandrine Grosse, Dirk Roymans, Sujata Sharma, Peter Rigaux, Zhinan Jin

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

Abstract The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and phosphoprotein (P), catalyzes nucleotide polymerization, cap addition, and cap methylation via the RNA dependent RNA polymerase, capping, and Methyltran

Externí odkaz: https://doaj.org/article/155faab50b5b48fe954bff5b07e1b8ac

From Oxetane to Thietane: Extending the Antiviral Spectrum of 2′-Spirocyclic Uridines by Substituting Oxygen with Sulfur

Autor: Sandrine Grosse, Abdellah Tahri, Pierre Raboisson, Yannis Houpis, Bart Stoops, Edgar Jacoby, Jean-Marc Neefs, Marnix Van Loock, Olivia Goethals, Peggy Geluykens, Jean-François Bonfanti, Tim H. M. Jonckers

Publikováno v: ACS Medicinal Chemistry Letters. 13:1879-1884

In continuation of our efforts of finding novel nucleoside inhibitors for the treatment of viral diseases, we initiated a discovery research program aimed at identifying novel nucleos(t)ide inhibitors for emerging diseases like Dengue and Chikungunya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a6a84c256df58b86b9b102ba666666
https://doi.org/10.1021/acsmedchemlett.2c00372

Synthesis of novel

Autor: Pierre, Sierocki, Krystal, Gaillard, Ruben Arturo, Arellano Reyes, Chloé, Donnart, Emilie, Lambert, Sandrine, Grosse, Laurence, Arzel, Arnaud, Tessier, Jerome, Guillemont, Monique, Mathé-Allainmat, Jacques, Lebreton

Publikováno v: Organicbiomolecular chemistry. 20(13)

A linear sequence to access a novel series of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12be39c59e11fe3baeb376f579cf95f9
https://pubmed.ncbi.nlm.nih.gov/35293914

Tuning the redox properties of a [4Fe-4S] center to modulate the activity of Mo-bisPGD periplasmic nitrate reductase

Autor: Bruno Guigliarelli, David Pignol, Kamal Zeamari, Guillaume Gerbaud, Florence Chaspoul, Pascal Arnoux, Bénédicte Burlat, Monique Sabaty, Sandrine Grosse, Vincent Fourmond, Frédéric Biaso

Publikováno v: Biochimica biophysica acta (BBA)-Bioenergetics
Biochimica biophysica acta (BBA)-Bioenergetics, Elsevier, 2019, 1860 (5), pp.402-413. ⟨10.1016/j.bbabio.2019.01.003⟩
Biochimica biophysica acta (BBA)-Bioenergetics, 2019, 1860 (5), pp.402-413. ⟨10.1016/j.bbabio.2019.01.003⟩

Molybdoenzymes are ubiquitous in living organisms and catalyze, for most of them, oxidation-reduction reactions using a large range of substrates. Periplasmic nitrate reductase (NapAB) from Rhodobacter sphaeroides catalyzes the 2-electron reduction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a315a22af5869c3c3d8d38817957028
https://hal-amu.archives-ouvertes.fr/hal-02106668

The Rhodobacter sphaeroides methionine sulfoxide reductase MsrP can reduce R- and S-diastereomers of methionine sulfoxide from a broad-spectrum of protein substrates

Autor: David Lemaire, Monique Sabaty, Jean Armengaud, David Pignol, Lionel Tarrago, Pascal Arnoux, Sandrine Grosse, Guylaine Miotello, Marina I. Siponen, Béatrice Alonso

SummaryMethionine (Met) is prone to oxidation and can be converted to Met sulfoxide (MetO), which exists as R- and S-diastereomers. MetO can be reduced back to Met by the ubiquitous methionine sulfoxide reductase (Msr) enzymes. Canonical MsrA and Msr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd14b20bc25502145fe6596d0ee713f