Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sandrine Georgeon"'
Autor:
Sailan Shui, Pablo Gainza, Leo Scheller, Che Yang, Yoichi Kurumida, Stéphane Rosset, Sandrine Georgeon, Raphaël B. Di Roberto, Rocío Castellanos-Rueda, Sai T. Reddy, Bruno E. Correia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. Here, we present a computational protein design strategy to repurpose drug-inhibited protein-protein interactions into OFF- and ON-switches ac
Externí odkaz:
https://doaj.org/article/abf45e9fa38440d9ad04bb724c9f71ce
Autor:
Daniel P. Duarte, Allan J. Lamontanara, Giuseppina La Sala, Sukyo Jeong, Yoo-Kyoung Sohn, Alejandro Panjkovich, Sandrine Georgeon, Tim Kükenshöner, Maria J. Marcaida, Florence Pojer, Marco De Vivo, Dmitri Svergun, Hak-Sung Kim, Matteo Dal Peraro, Oliver Hantschel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Constitutive Btk signaling drives several B-cell cancers. Here the authors demonstrate key allosteric intramolecular interactions between the SH2 domain and the kinase domain of Btk, and propose an alternative approach for inhibition of both wild-typ
Externí odkaz:
https://doaj.org/article/35d89457e02f4b24aac8c29d22647799
Autor:
Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The Bcr-Abl tyrosine kinases p210 and p190 are linked to different leukemias and differ by the Dbl homology (DH) and Pleckstrin-homology (PH) domains. Here the authors characterize structures of the Bcr-Abl p210 DH and PH domains and find that the PH
Externí odkaz:
https://doaj.org/article/dc5c32c8cdcb4768b619089187cee0d3
Autor:
Casper A. Goverde, Martin Pacesa, Lars J. Dornfeld, Sandrine Georgeon, Stéphane Rosset, Justas Dauparas, Christian Schellhaas, Simon Kozlov, David Baker, Sergey Ovchinnikov, Bruno E. Correia
De novodesign of protein folds with complex topologies and intricate structural features using solely computational means remains a significant challenge. Here, we use a robust deep learning pipeline to design soluble analogues of integral membrane p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::794d6aeea4c92b0503d76d7c6b83206a
https://doi.org/10.1101/2023.05.09.540044
https://doi.org/10.1101/2023.05.09.540044
Autor:
Anthony Marchand, Lucia Bonati, Sailan Shui, Leo Scheller, Pablo Gainza, Stéphane Rosset, Sandrine Georgeon, Li Tang, Bruno E. Correia
Protein-based therapeutics such as monoclonal antibodies and cytokines are important therapies in various pathophysiological conditions such as oncology, auto-immune disorders, and viral infections. However, the wide application of such protein thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb2cc117d44e84531faa102111335f2
https://doi.org/10.1101/2022.12.22.521584
https://doi.org/10.1101/2022.12.22.521584
Autor:
Pablo Gainza, Sarah Wehrle, Alexandra Van Hall-Beauvais, Anthony Marchand, Andreas Scheck, Zander Harteveld, Stephen Buckley, Dongchun Ni, Shuguang Tan, Freyr Sverrisson, Casper Goverde, Priscilla Turelli, Charlène Raclot, Alexandra Teslenko, Martin Pacesa, Stéphane Rosset, Sandrine Georgeon, Jane Marsden, Aaron Petruzzella, Kefang Liu, Zepeng Xu, Yan Chai, Pu Han, George F. Gao, Elisa Oricchio, Beat Fierz, Didier Trono, Henning Stahlberg, Michael Bronstein, Bruno E. Correia
Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic, and structural data grows. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae2dd2d3757cef1923a6c645e8be5972
https://doi.org/10.1101/2022.06.16.496402
https://doi.org/10.1101/2022.06.16.496402
Autor:
Sandrine Georgeon, Leo Scheller, Fabian Sesterhenn, Bruno E. Correia, Stéphane Rosset, Jaume Bonet, Martin Fussenegger, Theodore S. Jardetzky, Thomas Krey, Maarten Merkx, Johannes T. Cramer, Luciano A. Abriata, Xiaolin Wen, Che Yang, Eva A. van Aalen
Publikováno v:
Nature Chemical Biology, 17(4), 492-500. Nature Publishing Group
Nature Chemical Biology
Nature Chemical Biology
De novo protein design has enabled the creation of new protein structures. However, the design of functional proteins has proved challenging, in part due to the difficulty of transplanting structurally complex functional sites to available protein st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c1cff596e4a68e18da716290b1e0e3
http://www.scopus.com/inward/record.url?scp=85098772721&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85098772721&partnerID=8YFLogxK
Autor:
Roland Eils, Stéphane Rosset, Andreas Scheck, Jan Mathony, Julius Upmeier zu Belzen, Wei Sun, Bruno E. Correia, Christina Stengl, Sandrine Georgeon, Dominik Niopek, Mareike D. Hoffmann, Sabine Aschenbrenner, Carolin Schmelas, Zander Harteveld, Yanli Wang, Dirk Grimm
Publikováno v:
Nature Chemical Biology. 16:725-730
Anti-CRISPR (Acr) proteins are powerful tools to control CRISPR-Cas technologies. However, the available Acr repertoire is limited to naturally occurring variants. Here, we applied structure-based design on AcrIIC1, a broad-spectrum CRISPR-Cas9 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633addc7819fcadf4faf5cc3cab783af
https://doi.org/10.1038/s41589-020-0518-9
https://doi.org/10.1038/s41589-020-0518-9
Autor:
Bruno E. Correia, Che Yang, Sandrine Georgeon, Yoichi Kurumida, Sai T. Reddy, Stéphane Rosset, Leo Scheller, Pablo Gainza, Raphael Brisset Di Roberto, Sailan Shui, Rocío Castellanos-Rueda
Publikováno v:
Nature Communications
Nature Communications, 12
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, 12
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. However, the repertoire of small-molecule protein switches is insufficient for many applications, including those in the translational spaces,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5773273b0c24306e4435ccb946732d
https://doi.org/10.1038/s41467-021-25735-9
https://doi.org/10.1038/s41467-021-25735-9
Autor:
Yoichi Kurumida, Sandrine Georgeon, Pablo Gainza, Stéphane Rosset, Leo Scheller, Che Yang, Bruno E. Correia, Sailan Shui
Small-molecule responsive protein switches are crucial components to control synthetic cellular activities. However, the repertoire of small-molecule protein switches is insufficient for many applications, including those in the translational spaces,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63135033bd6e414bcd79e3edc7ec14c8
https://doi.org/10.1101/2021.01.21.427547
https://doi.org/10.1101/2021.01.21.427547