Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sandrine Desrayaud"'
Autor:
Nicolau Beckmann, Elisa Giorgetti, Anna Neuhaus, Stefan Zurbruegg, Nathalie Accart, Paul Smith, Julien Perdoux, Ludovic Perrot, Mark Nash, Sandrine Desrayaud, Peter Wipfli, Wilfried Frieauff, Derya R. Shimshek
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelin
Externí odkaz:
https://doaj.org/article/9fdc2fc9f13842ac8f3b0d040aeb08ed
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 65:343-350
The discovery of novel imaging agents for positron emission tomography (PET) relies on medicinal chemistry best practices, including a good understanding of molecular and pharmacological properties required for the acquisition of relevant, high-quali
Autor:
Seid Hamzic, Richard Lewis, Sandrine Desrayaud, Cihan Soylu, Mike Fortunato, Grégori Gerebtzoff, Raquel Rodríguez-Pérez
Publikováno v:
Journal of Chemical Information and Modeling. 62:3180-3190
Assessing whether compounds penetrate the brain can become critical in drug discovery, either to prevent adverse events or to reach the biological target. Generally, pre-clinical in vivo studies measuring the ratio of brain and blood concentrations (
Autor:
Robin A. Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Clive McCarthy, Sebastien Ripoche, Susanne Oswald, Bertrand Arnaud, Aline Jary, Michel Maira, Christian Schnell, Daniel A. Guthy, Markus Wartmann, Michael Kiffe, Sandrine Desrayaud, Francesca Blasco, Toni Widmer, Frank Seiler, Sascha Gutmann, Mark Knapp, Giorgio Caravatti
Publikováno v:
Journal of Medicinal Chemistry. 65:8345-8379
Balanced pan-class I phosphoinositide 3-kinase inhibition as an approach to cancer treatment offers the prospect of treating a broad range of tumor types and/or a way to achieve greater efficacy with a single inhibitor. Taking buparlisib as the start
Autor:
Nathalie Accart, Elisa Giorgetti, Stefan Zurbruegg, Sandrine Desrayaud, Mark Nash, Ludovic Perrot, Paul Smith, Derya R. Shimshek, Wilfried Frieauff, Peter Wipfli, Anna Neuhaus, Nicolau Beckmann, Julien Perdoux
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they lack the scope of promoting CNS repair, in particular remyelination. Mi
Design and Synthesis of Selurampanel, a Novel Orally Active and Competitive AMPA Receptor Antagonist
Autor:
David Orain, Kurt Lingenhoehl, Sandrine Desrayaud, David Carcache, Joerg Kallen, Anne Picard, Stephan Urwyler, Phillip Floersheim, Engin Tasdelen, Manuel Koller, Celine Dubois, Samuel Haessig, Henri Mattes
Publikováno v:
ChemMedChem. 12:197-201
A series of potent quinazolinedione sulfonamide antagonists of the α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor were designed and synthesized. The structure-activity relationships (SAR) and in vivo activity of the series wer
Autor:
Aimar Martin Garcia, Markus Blatter, Marianne Fouché, Philippe Piechon, Sandrine Desrayaud, Hans-Jörg Roth, Michael Schäfer, Ina Dix, Jörg Berghausen
Publikováno v:
ChemMedChem. 11:1048-1059
Permeability and oral bioavailability of macrocyclic peptides still represent difficult challenges in drug discovery. Despite the recognized potential of macrocyclic peptides as therapeutics, their use is still restricted to extracellular targets and
Autor:
Sandrine Desrayaud, Francis Risser, Catherine Afatsawo, Daniel Lehmann, Philip Arabin, Valerie Cordier, Laurent Hoffmann, Toni Widmer, Peter Wipfli, Marc Bigaud, Julia Thiel, Phil Lowe, Rowan Stringer
1. The utility of 1-aminobenzotriazole (ABT), incorporated in food, has been investigated as an approach for longer term inhibition of cytochrome P450 (P450) enzymes in mice. 2. In rats, ABT inhibits gastric emptying, to investigate this potential li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb256f3c00f7612540ff67c495f1665
Publikováno v:
ChemMedChem. 10:1008-1018
BAF312 (siponimod) is a sphingosine-1-phosphate (S1P) receptor modulator in clinical development for the treatment of multiple sclerosis, with faster organ/tissue distribution and elimination kinetics than its precursor FTY720 (fingolimod). Our aim w