Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Sandrine Da Cruz"'
Autor:
Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, a proteinopathy of fused in sarcoma (FUS) is present in some instances of familial Amyotrophic lateral sclerosis (ALS)
Externí odkaz:
https://doaj.org/article/95638d30dda343ee9bedd62a7544c554
Autor:
Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likely to be a major culprit in the t
Externí odkaz:
https://doaj.org/article/99efacbef7004ce6bd0c304590be3071
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Philippe A Parone, Sandrine Da Cruz, Daniel Tondera, Yves Mattenberger, Dominic I James, Pierre Maechler, François Barja, Jean-Claude Martinou
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3257 (2008)
Mitochondria form a highly dynamic tubular network, the morphology of which is regulated by frequent fission and fusion events. However, the role of mitochondrial fission in homeostasis of the organelle is still unknown. Here we report that preventin
Externí odkaz:
https://doaj.org/article/30d4572743f44d3280a1e26a703bec07
Publikováno v:
Neuron. 111:1355-1380
Publikováno v:
Journal of Visualized Experiments.
Autor:
Don W. Cleveland, Amy Taylor, Albert R. La Spada, Clotilde Lagier-Tourenne, Jie Jiang, Tania F. Gendron, Sandra Diaz Garcia, Huaxi Xu, John Ravits, Somasish Ghosh Dastidar, Lu-Lin Jiang, Leonard Petrucelli, Melissa McAlonis-Downes, María José Cubillas Rodríguez, Patrick King, Sandrine Da Cruz, Qiang Zhu, Yong Jie Zhang
Publikováno v:
Nature Neuroscience. 23:615-624
Hexanucleotide expansions in C9orf72, which encodes a predicted guanine exchange factor, are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although repeat expansion has been established to g
Autor:
Don W. Cleveland, Lu-Lin Jiang, Tongfei Liu, Wenxi Xu, Lisa Zhou, Huaxi Xu, Tao Long, Sandrine Da Cruz, María Jesús Delgado Rodríguez, Yingjun Zhao, Dongxian Zhang, Xiaoguang Li, Juan C. Piña-Crespo, Timothy Y. Huang, John Ravits, Bing Zhu, Haiyang Yu
Publikováno v:
Journal of Clinical Investigation. 129:3103-3120
Mechanisms underlying motor neuron degeneration in amyotrophic lateral sclerosis (ALS) are yet unclear. Specific deletion of the ER-component membralin in astrocytes manifested postnatal motor defects and lethality in mice, causing the accumulation o
Autor:
Michael Baughn, Ze’ev Melamed, C. Frank Bennett, Ying Sun, Frank Rigo, María José Cubillas Rodríguez, Sandrine Da Cruz, Fernande Freyermuth, John Ravits, Melinda S. Beccari, Kevin Drenner, Moira A. McMahon, Clotilde Lagier-Tourenne, Ouyang Zhang, Dongmei Wu, Takuya Ohkubo, Jon Artates, Don W. Cleveland, Nianwei Lin, Jone López-Erauskin
Publikováno v:
Nature neuroscience
Nature neuroscience, vol 22, iss 2
Nature neuroscience, vol 22, iss 2
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are associated with loss of nuclear transactive response DNA-binding protein 43 (TDP-43). Here we identify that TDP-43 regulates expression of the neuronal growth-associated factor
Autor:
Digvijay Singh, Kelsey Gasior, Shan Lu, Olga Tapia, Amy S. Gladfelter, Elizabeth Villa, Don W. Cleveland, John R. Yates, Sandrine Da Cruz, Melinda S. Beccari, Divek Toprani, Jay M. Newby, Haiyang Yu, Miguel Lafarga, Sonia Vazquez-Sanchez
Publikováno v:
Science
The makings of anisosomes Phase separation of proteins within the cell can produce a liquid-inside-a-liquid phase resembling oil droplets in water. Yu et al. now report that an RNA-binding protein called TDP-43, in which mutation and aggregation are