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pro vyhledávání: '"Sandrine Bonnet-Lignon"'
Autor:
Laurence Millet, Angelina Besse, Stéphanie Tissandié, Gernot Zech, Marie-Francoise Bordes, Alain Badorc, Lassalle Gilbert, Valerie Fossey, Jean-Pascal Herault, Frédérique Dol, Christophe Boldron, Benjamin Gau, Christophe Briot, Nathalie Delesque, Anne-Marie Pflieger, Françoise Bono, Xavier Yvon, Marc Nazaré, Guillaume Barre, Tristan Rousseaux, Jean-Marc Herbert, Sandrine Bonnet-Lignon, Jerome Meneyrol, Pierre Savi
Publikováno v:
Journal of medicinal chemistry. 57(17)
In the search of a potential backup for clopidogrel, we have initiated a HTS campaign designed to identify novel reversible P2Y12 antagonists. Starting from a hit with low micromolar binding activity, we report here the main steps of the optimization