Epigenetic regulation of transcription factor binding motifs promotes Th1 response in Chagas disease cardiomyopathy

Autor: Pauline Brochet, Barbara Maria Ianni, Laurie Laugier, Amanda Farage Frade, João Paulo Silva Nunes, Priscila Camillo Teixeira, Charles Mady, Ludmila Rodrigues Pinto Ferreira, Quentin Ferré, Ronaldo Honorato Barros Santos, Andreia Kuramoto, Sandrine Cabantous, Samuel Steffen, Antonio Noedir Stolf, Pablo Pomerantzeff, Alfredo Inacio Fiorelli, Edimar Alcides Bocchi, Cristina Wide Pissetti, Bruno Saba, Darlan da Silva Cândido, Fabrício C. Dias, Marcelo Ferraz Sampaio, Fabio Antônio Gaiotto, José Antonio Marin-Neto, Abílio Fragata, Ricardo Costa Fernandes Zaniratto, Sergio Siqueira, Giselle De Lima Peixoto, Vagner Oliveira-Carvalho Rigaud, Fernando Bacal, Paula Buck, Rafael Ribeiro Almeida, Hui Tzu Lin-Wang, André Schmidt, Martino Martinelli, Mario Hiroyuki Hirata, Eduardo Antonio Donadi, Alexandre Costa Pereira, Virmondes Rodrigues Junior, Denis Puthier, Jorge Kalil, Lionel Spinelli, Edecio Cunha-Neto, Christophe Chevillard

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Chagas disease, caused by the protozoan Trypanosoma cruzi, is an endemic parasitic disease of Latin America, affecting 7 million people. Although most patients are asymptomatic, 30% develop complications, including the often-fatal Chronic Chagasic Ca

Externí odkaz: https://doaj.org/article/65fdda843b04496390e425c5897c4f93

Corrigendum: Polymorphisms in Genes Affecting Interferon-γ Production and Th1 T Cell Differentiation Are Associated With Progression to Chagas Disease Cardiomyopathy

Autor: Amanda Farage Frade-Barros, Barbara Maria Ianni, Sandrine Cabantous, Cristina Wide Pissetti, Bruno Saba, Hui Tzu Lin-Wang, Paula Buck, José Antonio Marin-Neto, André Schmidt, Fabrício Dias, Mario Hiroyuki Hirata, Marcelo Sampaio, Abílio Fragata, Alexandre Costa Pereira, Eduardo Donadi, Virmondes Rodrigues, Jorge Kalil, Christophe Chevillard, Edecio Cunha-Neto

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Externí odkaz: https://doaj.org/article/0d1e7ffea4084911bd0c2cf1820b6740

Understanding Human Cerebral Malaria through a Blood Transcriptomic Signature: Evidences for Erythrocyte Alteration, Immune/Inflammatory Dysregulation, and Brain Dysfunction

Autor: Sandrine Cabantous, Belco Poudiougou, Aurélie Bergon, Abdoulaye Barry, Aboubacar A. Oumar, Abdoulaye M. Traore, Christophe Chevillard, Ogobara Doumbo, Alain Dessein, Sandrine Marquet

Publikováno v: Mediators of Inflammation, Vol 2020 (2020)

Background. Cerebral malaria (CM), a reversible encephalopathy affecting young children, is a medical emergency requiring rapid clinical assessment and treatment. However, understanding of the genes/proteins and the biological pathways involved in th

Externí odkaz: https://doaj.org/article/f251612bfea643eea0c681ba2ff0b8d7

FOXP3+ Regulatory T Cells in Hepatic Fibrosis and Splenomegaly Caused by Schistosoma japonicum: The Spleen May Be a Major Source of Tregs in Subjects with Splenomegaly.

Autor: Audrey Romano, Xunya Hou, Mathieu Sertorio, Hélia Dessein, Sandrine Cabantous, Pablo Oliveira, Jun Li, Sandrine Oyegue, Violaine Arnaud, Xinsong Luo, Martine Daujat-Chavanieu, Odette Mariani, Xavier Sastre, Anne-Marie Dombey, Hongbin He, Yuesheng Li, Alain Dessein

Publikováno v: PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004306 (2016)

Schistosoma eggs cause chronic liver inflammation and a complex disease characterized by hepatic fibrosis (HF) and splenomegaly (SplM). FOXP3+ Tregs could regulate inflammation, but it is unclear where these cells are produced and what roles they pla

Externí odkaz: https://doaj.org/article/e7365a8449ea42b6baca45782d2c1893

GATA1 pathogenic variants disrupt MYH10 silencing during megakaryopoiesis

Autor: Timothée Bigot, Marie Loosveld, Noémie Saut, Paul Saultier, Céline Falaise, Pierre-Emmanuel Morange, Sandrine Cabantous, Franck Peiretti, Johannes van Agthoven, Jean-Claude Bordet, Denis Bernot, Delphine Potier, Dominique Payet-Bornet, Matthias Canault, Michel Pucéat, Marie-Christine Alessi, Marjorie Poggi

Publikováno v: Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis, 2021, 19 (9), pp.2287-2301. ⟨10.1111/jth.15412⟩
Journal of Thrombosis and Haemostasis, Wiley, 2021, 19 (9), pp.2287-2301. ⟨10.1111/jth.15412⟩

International audience; BackgroundGATA1 is an essential transcription factor for both polyploidization and megakaryocyte (MK) differentiation. The polyploidization defect observed in GATA1 variant carriers is not well understood.ObjectiveTo extensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634bb6b82ec2348af9f619f47d61b6aa
https://hal-amu.archives-ouvertes.fr/hal-03374701