Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson’s Disease

Autor: Irene Sanchez-Mirasierra, Saurav Ghimire, Sergio Hernandez-Diaz, Sandra-Fausia Soukup

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Macroautophagy, an evolutionary conserved catabolic process in the eukaryotic cell, regulates cellular homeostasis and plays a decisive role in self-engulfing proteins, protein aggregates, dysfunctional or damaged organelles, and invading pathogens.

Externí odkaz: https://doaj.org/article/24bce31c99cd478e84d4526616e7e927

Endophilin-B regulates autophagy during synapse development and neurodegeneration

Autor: Sergio Hernandez-Diaz, Saurav Ghimire, Irene Sanchez-Mirasierra, Carla Montecinos-Oliva, Jef Swerts, Sabine Kuenen, Patrik Verstreken, Sandra-Fausia Soukup

Publikováno v: Neurobiology of Disease, Vol 163, Iss , Pp 105595- (2022)

Synapses are critical for neuronal communication and brain function. To maintain neuronal homeostasis, synapses rely on autophagy. Autophagic alterations cause neurodegeneration and synaptic dysfunction is a feature in neurodegenerative diseases. In

Externí odkaz: https://doaj.org/article/39994361b8a24ea5ba854ac48b17bd08

Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System

Autor: John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic

Publikováno v: Cell Reports, Vol 17, Iss 4, Pp 1071-1086 (2016)

Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodeg

Externí odkaz: https://doaj.org/article/b3675368bb464b4481786ffb5883f006

Contributors

Autor: Mahmoud Abdellatif, Nuzhat Ahsan, Amelina Albornoz, Yahyah Aman, Allen Andres, Catherine Arden, Daniel Asa, Belén Bellido, Sihem Boudina, Alfredo Briones-Herrera, Mauricio Budini, Elizabeth Bueno, Olivier Camuzard, Georges F. Carle, Santosh Chauhan, Ramon Corbalan, Alfredo Criollo, Srinivasulu Dasanna, Guido R.Y. De Meyer, Abhinav Diwan, Maria Jose Donate-Lagartos, Robyn Duttenhefner, Tobias Eisenberg, Evandro F. Fang, Johannes Frank, Valeria Garrido-Moreno, Luis Garrido-Olivares, Merilin Georgiou, Saurav Ghimire, Tania Gómez-Sierra, Ruben Gudmundsrud, Andreas Guenther, Pieter-Jan Guns, Congcong He, G. Vignir Helgason, Nina Hermans, Sergio Hernandez-Diaz, Angela Ianniciello, Moydul Islam, Kautilya Kumar Jena, Hiroshi Katsuki, Martina Korfei, Viktor I. Korolchuk, Nicholas T. Ktistakis, Sergio Lavandero, Mark Li, Senka Ljubojević-Holzer, Poornima Mahavadi, Patrick Main, Maria Manifava, Greg R. Markby, Wim Martinet, Elena Martínez-Klimova, Subhash Mehto, Jason C. Mills, Cédric HG. Neutel, Ngoc Uyen Nhi Nguyen, José Pedraza-Chaverri, Daniel Peña-Oyarzún, Valérie Pierrefite-Carle, Felipe X. Pimentel-Muiños, Thomas Pulinilkunnil, Yoana Rabanal-Ruiz, Megan D. Radyk, Christian Rodríguez, Lynn Roth, Beverly A. Rothermel, Kei Sakamoto, Irene Sanchez-Mirasierra, Simon Sedej, Takahiro Seki, Alvaro Sequeida, Liu Shi, Sangita C. Sinha, Logan Slade, Sandra-Fausia Soukup, Lillian B. Spatz, Bieke Steenput, Takayuki Tatsumi, Kateřina Čechová, Marie-Charlotte Trojani, Satoshi Tsukamoto, Silvia Vega-Rubín-de-Celis, Vishaka Vinod, Martin Vyhnalek, Amelia Williams, Samuel Wyatt, Chenglong Xie, Ling Yang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9b7da36fa6e070b2f6b58871b491c5f
https://doi.org/10.1016/b978-0-12-822003-0.01002-0

Parkinson's disease: convergence on synaptic homeostasis

Autor: Roeland Vanhauwaert, Patrik Verstreken, Sandra-Fausia Soukup

Publikováno v: The EMBO Journal

Parkinson's disease, the second most common neurodegenerative disorder, affects millions of people globally. There is no cure, and its prevalence will double by 2030. In recent years, numerous causative genes and risk factors for Parkinson's disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f819d4ba69c1fc8650e01a6d77e337
https://pubmed.ncbi.nlm.nih.gov/30065071