172 Cancer immunotherapy response monitoring with whole blood immuno-transcriptomic profiling

Autor: Pedro Romero, Niven Mehra, Laura Ciarloni, Noushin Hadadi, Rutger Koornstra, Sandra van Wilpe, Eric Durandau, Sahar Hosseinian Ehrensberger, Sylvain Monnier-Benoit

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/9454f6fefa14449d81a2b1c388af4fcc

LDH Isotyping for Checkpoint Inhibitor Response Prediction in Patients with Metastatic Melanoma

Autor: Sandra van Wilpe, Sofie H. Tolmeijer, I. Jolanda M. de Vries, Rutger H. T. Koornstra, Niven Mehra

Publikováno v: Immuno, Vol 1, Iss 2, Pp 67-77 (2021)

Serum lactate dehydrogenase (LDH) levels are inversely related with response to immune checkpoint inhibitors (ICIs) in patients with metastatic melanoma. LDH is a key regulator of glycolysis, a pathway known to be upregulated in malignant tumors and

Externí odkaz: https://doaj.org/article/7c6400368640468aaca3667a0209b54f

Immunophenotyping Reveals Longitudinal Changes in Circulating Immune Cells During Radium-223 Therapy in Patients With Metastatic Castration-Resistant Prostate Cancer

Autor: Jeroen H. A. Creemers, Maarten J. van der Doelen, Sandra van Wilpe, Rick Hermsen, Tjitske Duiveman-de Boer, Diederik M. Somford, Marcel J. R. Janssen, J. P. Michiel Sedelaar, Niven Mehra, Johannes Textor, Harm Westdorp

Publikováno v: Frontiers in Oncology, Vol 11 (2021)

BackgroundRadium-223 improves overall survival (OS) in men with bone metastatic castration-resistant prostate cancer (mCRPC). While the exact mechanism behind this survival benefit remains unclear, radium-induced immunological mechanisms might contri

Externí odkaz: https://doaj.org/article/9681b271f3804ad081b66ebff52e0e79

Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma

Autor: J. Alberto Nakauma-González, Maud Rijnders, Job van Riet, Michiel S. van der Heijden, Jens Voortman, Edwin Cuppen, Niven Mehra, Sandra van Wilpe, Sjoukje F. Oosting, L. Lucia Rijstenberg, Hans M. Westgeest, Ellen C. Zwarthoff, Ronald de Wit, Astrid A.M. van der Veldt, Harmen J.G. van de Werken, Martijn P.J. Lolkema, Joost L. Boormans

Publikováno v: Nakauma-González, J A, Rijnders, M, van Riet, J, van der Heijden, M S, Voortman, J, Cuppen, E, Mehra, N, van Wilpe, S, Oosting, S F, Rijstenberg, L L, Westgeest, H M, Zwarthoff, E C, de Wit, R, van der Veldt, A A M, van de Werken, H J G, Lolkema, M P J & Boormans, J L 2022, ' Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma ', European Urology, vol. 81, no. 4, pp. 331-336 . https://doi.org/10.1016/j.eururo.2022.01.026
European Urology, 81(4), 331-336. Elsevier
European Urology, 81(4), 331-336. ELSEVIER SCIENCE BV
European Urology, 81, 331-336
European Urology, 81, 4, pp. 331-336

Contains fulltext : 249819.pdf (Publisher’s version ) (Open Access) Recent molecular characterization of primary urothelial carcinoma (UC) may guide future clinical decision-making. For metastatic UC (mUC), a comprehensive molecular characterizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0254ca9ff84291d08024ee4f29df83e3
https://doi.org/10.1016/j.eururo.2022.01.026

Intratumoral T cell depletion following neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer is associated with poor clinical outcome

Autor: Sandra, van Wilpe, Shabaz, Sultan, Mark A J, Gorris, Diederik M, Somford, Heidi V N, Kusters-Vandevelde, Rutger H T, Koornstra, Winald R, Gerritsen, Michiel, Simons, Antoine G, van der Heijden, I Jolanda M, de Vries, Niven, Mehra

Publikováno v: Cancer immunology, immunotherapy : CII. 72(1)

Whereas neoadjuvant cisplatin-based chemotherapy (NAC) followed by a radical cystectomy remains the standard treatment for patients with muscle-invasive bladder cancer (MIBC), increasing evidence suggests that checkpoint inhibitors, either alone or i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ae9f7af25204ebe4a26c7afbe8432c8
https://pubmed.ncbi.nlm.nih.gov/35771253