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Akademický článek

Actionable mutational profiling in solid tumors using hybrid‐capture‐based next‐generation sequencing in a real‐world setting in Spain

Autor: Sandra Zazo, Sandra Pérez‐Buira, Nerea Carvajal, Jenifer Plaza‐Sánchez, Rebeca Manso, Nuria Pérez‐González, Carolina Dominguez, Iván Prieto‐Potin, Jaime Rubio, Manuel Dómine, Virginia Lozano, Patricia Mohedano, David Carcedo, Rafael Carias, Federico Rojo

Publikováno v: Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)

Abstract Objective This study aimed to describe the performance of a next‐generation sequencing (NGS) panel for the detection of precise genomic alterations in cancer in Spanish clinical practice. The impact of tumor characteristics was evaluated o

Externí odkaz: https://doaj.org/article/f005a061fa8f46aca3f748bc4be3e83f

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Akademický článek

In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network

Autor: Margalida Esteva-Socias, María-Jesús Artiga, Olga Bahamonde, Oihana Belar, Raquel Bermudo, Erika Castro, Teresa Escámez, Máximo Fraga, Laura Jauregui-Mosquera, Isabel Novoa, Lorena Peiró-Chova, Juan-David Rejón, María Ruiz-Miró, Paula Vieiro-Balo, Virginia Villar-Campo, Sandra Zazo, Alberto Rábano, Cristina Villena

Publikováno v: Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-14 (2019)

Abstract The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by the Biospecimen Sci

Externí odkaz: https://doaj.org/article/a04ff2a1283f4782bd08df4ae8015ed5

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Akademický článek

Comprehensive Approach to Genomic and Immune Profiling: Insights of a Real-World Experience in Gynecological Tumors

Publikováno v: Diagnostics, Vol 12, Iss 8, p 1903 (2022)

Gynecological cancer accounts for an elevated incidence worldwide requiring responsiveness regarding its care. The comprehensive genomic approach agrees with the classification of certain tumor types. We evaluated 49 patients with gynecological tumor

Externí odkaz: https://doaj.org/article/5997035934bb459c94fd59bc4cba53f2

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Akademický článek

Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies

Autor: Iván Prieto-Potin, Nerea Carvajal, Jenifer Plaza-Sánchez, Rebeca Manso, Carmen Laura Aúz-Alexandre, Cristina Chamizo, Sandra Zazo, Almudena López-Sánchez, Socorro María Rodríguez-Pinilla, Laura Camacho, Raquel Longarón, Beatriz Bellosillo, Rosa Somoza, Javier Hernández-Losa, Víctor Manuel Fernández-Soria, Ricardo Ramos-Ruiz, Ion Cristóbal, Jesús García-Foncillas, Federico Rojo

Publikováno v: PeerJ, Vol 8, p e10069 (2020)

Background Next-generation sequencing (NGS) is a high-throughput technology that has become widely integrated in molecular diagnostics laboratories. Among the large diversity of NGS-based panels, the Trusight Tumor 26 (TsT26) enables the detection of

Externí odkaz: https://doaj.org/article/6a82bc40e8c845f88d8f03973d27e115

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Akademický článek

Colon cancer modulation by a diabetic environment: A single institutional experience.

Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0172300 (2017)

BACKGROUND:Multiple observational studies suggest an increased risk of colon cancer in patients with diabetes mellitus (DM). This can theoretically be the result of an influence of the diabetic environment on carcinogenesis or the tumor biologic beha

Externí odkaz: https://doaj.org/article/093b7915bf0f48549b17b68362a443a7

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Akademický článek

Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma

Autor: Asunción Fernández-Barral, Jose Luis Orgaz, Pablo Baquero, Zaheer Ali, Alberto Moreno, María Tiana, Valentí Gómez, Erica Riveiro-Falkenbach, Carmen Cañadas, Sandra Zazo, Corine Bertolotto, Irwin Davidson, Jose Luis Rodríguez-Peralto, Ignacio Palmero, Federico Rojo, Lasse Dahl Jensen, Luis del Peso, Benilde Jiménez

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 6, Pp 529-542 (2014)

Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells. Here we show that PEDF expression

Externí odkaz: https://doaj.org/article/2fbad16e8fa34639b68b92e2466246f6

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Akademický článek

Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis.

Autor: Rodrigo Fernández-Periáñez, Irene Molina-Privado, Federico Rojo, Irene Guijarro-Muñoz, Vanesa Alonso-Camino, Sandra Zazo, Marta Compte, Ana Alvarez-Cienfuegos, Angel M Cuesta, David Sánchez-Martín, Ana M Alvarez-Méndez, Laura Sanz, Luis Alvarez-Vallina

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72957 (2013)

Metastatic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in syste

Externí odkaz: https://doaj.org/article/5ee65d3045ff4059abeaf2b357359dba

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Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer

Publikováno v: Science Advances
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Consejo Superior de Investigaciones Científicas (CSIC)
Scientia

Breast cancer; Heterodimerization Cáncer de mama; Heterodimerización Càncer de mama; Heterodimerització Anti-HER2 therapies have markedly improved prognosis of HER2-positive breast cancer. However, different mechanisms play a role in treatment re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fb8c5eed3e6e740807833312138fdd
http://hdl.handle.net/2445/197295

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