A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets

Autor: Francisca F. Almeida, Sara Tognarelli, Antoine Marçais, Andrew J. Kueh, Miriam E. Friede, Yang Liao, Simon N. Willis, Kylie Luong, Fabrice Faure, Francois E. Mercier, Justine Galluso, Matthew Firth, Emilie Narni-Mancinelli, Bushra Rais, David T. Scadden, Francesco Spallotta, Sandra Weil, Ariane Giannattasio, Franziska Kalensee, Tobias Zöller, Nicholas D. Huntington, Ulrike Schleicher, Andreas G. Chiocchetti, Sophie Ugolini, Marco J. Herold, Wei Shi, Joachim Koch, Alexander Steinle, Eric Vivier, Thierry Walzer, Gabrielle T. Belz, Evelyn Ullrich

Publikováno v: OncoImmunology, Vol 7, Iss 10 (2018)

NKp46 (CD335) is a surface receptor shared by both human and mouse natural killer (NK) cells and innate lymphoid cells (ILCs) that transduces activating signals necessary to eliminate virus-infected cells and tumors. Here, we describe a spontaneous p

Externí odkaz: https://doaj.org/article/8e7af400c12d41358fe2c4876853dbc4

Engineered Technologies and Bioanalysis of multispecific Antibody Formats

Autor: Ercole Rao, Melanie Fischer, Marta Amaral, Sandra Weil, Soraya Hölper, Hanno Sjuts, Christian Lange, Jennifer Jung, Katarina Radoevic

Publikováno v: Journal of Applied Bioanalysis, Vol 6, Iss 1, Pp 26-51 (2020)

The idea of designing multispecific antibodies capable of simultaneously engaging two or more epitopes on the same or different antigens was developed more than 50 years ago. However, the molecular complexity of such molecules may pose significant ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8b04b9423433560b509d38e793e59c
https://doi.org/10.17145/jab.20.005

Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium

Autor: Joachim Koch, Stefan Leibelt, Miriam E. Friede, Christina Born, Emilia Rutkowski, Stefan Bauer, Alexander Steinle, Sandra Weil

Publikováno v: The Journal of Immunology. 198:916-926

The mouse gut epithelium represents a constitutively challenged environment keeping intestinal commensal microbiota at bay and defending against invading enteric pathogens. The complex immunoregulatory network of the epithelial barrier surveillance a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f056ef53cadc899342236cc717d24e
https://doi.org/10.4049/jimmunol.1600666

A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets

Autor: Ariane Giannattasio, Sophie Ugolini, Marco J Herold, Thierry Walzer, Andrew J. Kueh, Wei Shi, Alexander Steinle, Tobias Zöller, Francisca F. Almeida, Miriam E. Friede, Kylie Luong, Bushra Rais, Nicholas D. Huntington, Justine Galluso, Joachim Koch, Emilie Narni-Mancinelli, Matthew A. Firth, David T. Scadden, Sara Tognarelli, Simon N. Willis, Evelyn Ullrich, Fabrice Faure, Yang Liao, Ulrike Schleicher, Antoine Marçais, Eric Vivier, Sandra Weil, Francois Mercier, Gabrielle T. Belz, Andreas G. Chiocchetti, Franziska Kalensee, Francesco Spallotta

Publikováno v: OncoImmunology
OncoImmunology, 2018, 7 (10), pp.e1475875. ⟨10.1080/2162402X.2018.1475875⟩
OncoImmunology, Taylor & Francis, 2018, 7 (10), pp.e1475875. ⟨10.1080/2162402X.2018.1475875⟩
Oncoimmunology
OncoImmunology, Vol 7, Iss 10 (2018)

International audience; NKp46 (CD335) is a surface receptor shared by both human and mouse natural killer (NK) cells and innate lymphoid cells (ILCs) that transduces activating signals necessary to eliminate virus-infected cells and tumors. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484bfa82ff3392c64abe59325cfeb20f
https://amu.hal.science/hal-02086847

Natural Killer Group 2D Ligand Depletion Reconstitutes Natural Killer Cell Immunosurveillance of Head and Neck Squamous Cell Carcinoma

Autor: Tamara Becker, Eva Herrmann, Karen Lampe, Andreas Müller-Runte, Dirk Beutner, Michael von Bergwelt-Baildon, Alexander Steinle, Lutz Walter, Axel Lechner, Joachim Koch, Stefanie Memmer, Alexander Quaas, Volker Huppert, Ariane Giannattasio, Ralf Schubert, Sandra Weil, Ulrike Koehl

Publikováno v: Frontiers in Immunology

Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous and aggressive tumor originating from the epithelial lining of the upper aero-digestive tract accounting for 300,000 annual deaths worldwide due to failure of current therapies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46d24313c69e3d25aa15db001b48ffc