The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Autor: Gabriele Stephan, Lumei Huang, Yong Tang, Sandra Vilotti, Elsa Fabbretti, Ye Yu, Wolfgang Nörenberg, Heike Franke, Flóra Gölöncsér, Beáta Sperlágh, Anke Dopychai, Ralf Hausmann, Günther Schmalzing, Patrizia Rubini, Peter Illes

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two io

Externí odkaz: https://doaj.org/article/a74b5c103f5b4b358a8a947c36ebe64a

B-type natriuretic peptide-induced delayed modulation of TRPV1 and P2X3 receptors of mouse trigeminal sensory neurons.

Autor: Sandra Vilotti, Anna Marchenkova, Niels Ntamati, Andrea Nistri

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81138 (2013)

Important pain transducers of noxious stimuli are small- and medium-diameter sensory neurons that express transient receptor vanilloid-1 (TRPV1) channels and/or adenosine triphosphate (ATP)-gated P2X3 receptors whose activity is upregulated by endoge

Externí odkaz: https://doaj.org/article/f2e398a6b08d4562ad1cd2416cabc19e

Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6.

Autor: Sandra Vilotti, Marta Codrich, Marco Dal Ferro, Milena Pinto, Isidro Ferrer, Licio Collavin, Stefano Gustincich, Silvia Zucchelli

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e35051 (2012)

Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson's disease (PD). Although large gene deletions have been linked to a loss-of-function phenotype, the pathogenic mechanism of missense mutations is less c

Externí odkaz: https://doaj.org/article/4c2bbae141594ad28abdbc2dd8f3d3fa

Hyperpolarization-activated current I h in mouse trigeminal sensory neurons in a transgenic mouse model of familial hemiplegic migraine type-1

Autor: Arn M. J. M. van den Maagdenberg, Sandra Vilotti, Francesca Eroli, Andrea Nistri

Publikováno v: Neuroscience, 351, 47-64

Transgenic knock-in (KI) mice that express CaV2.1 channels containing an R192Q gain-of-function mutation in the α1A subunit known to cause familial hemiplegic migraine type-1 in patients, exhibit key disease characteristics and provide a useful tool

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d60bc7693e7331265f6bca12d06450c
https://doi.org/10.1016/j.neuroscience.2017.03.033

Author Correction: The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel

Autor: Wolfgang Nörenberg, Ye Yu, Sandra Vilotti, Anke Dopychai, Beáta Sperlágh, Heike Franke, Gabriele Stephan, Yong Tang, Elsa Fabbretti, Patrizia Rubini, Ralf Hausmann, Günther Schmalzing, Flóra Gölöncsér, Peter Illes, Lumei Huang

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 9, 3351 (2018). doi:10.1038/s41467-018-05621-7
Nature Communications

Two subclasses of acid-sensing ion channels (ASIC3) and of ATP-sensitive P2X receptors (P2X3Rs) show a partially overlapping expression in sensory neurons. Here we report that both recombinant and native receptors interact with each other in multiple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9961fe6ea74bea590e916e894a8199
https://doi.org/10.1038/s41467-018-05621-7