Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sandra Vatter"'
Autor:
Andrea Thommet, Gerhard Eisenbrand, Sandra Vatter, Stephan Muehlbeyer, Jochen Christ, Karl-Heinz Merz, Stefan Wölfl, Xinlai Cheng, Jochen Zeller
Publikováno v:
Journal of medicinal chemistry. 60(12)
Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5- and 3'-position have been extensively investigated, but the impact of substituents in 5'-position is not equally well-studied. Her
Autor:
Corinna E. Rüfer, Diana Fridrich, Sandra Vatter, Anja Nussher, S. Skrbek, Julia Reichert, Doris Marko, Gudrun Pahlke, Sabine Hofem, Melanie Kern
Publikováno v:
Molecular Nutrition & Food Research. 51:1163-1172
In the present study we investigated the stability of anthocyanidins under cell culture conditions and addressed the question whether degradation products might contribute to the cellular effects assigned to the parent compounds. Substantial degradat
Publikováno v:
Molecular Nutrition & Food Research. 50:390-395
Malvidin (mv) has been identified as a potential inhibitor of 3',5'-cyclic adenosine monophosphate (cAMP) phosphodiesterases (PDE). This study was to investigate if, as a possible consequence of intracellular PDE inhibition, the activity of the mitog
Autor:
Ralf Buettner, Jin Q. Cheng, Sandra Vatter, Karl-Heinz Merz, Gerhard Eisenbrand, Sangkil Nam, James Turkson, Donghwa Kim, Stephan Muehlbeyer, Richard Jove, Frankie Hippe
Publikováno v:
Proceedings of the National Academy of Sciences. 102:5998-6003
Stat3 protein has an important role in oncogenesis and is a promising anticancer target. Indirubin, the active component of a traditional Chinese herbal medicine, has been shown previously to inhibit cyclin-dependent kinases, resulting in cell cycle
Publikováno v:
Journal of Neurochemistry. 93:321-329
A promising attempt in the field of tumour therapy is the modulation of intracellular, proliferation-associated signalling pathways. The role of cyclic nucleotide phosphodiesterases (PDEs), key enzymes in cAMP/cGMP signal transduction, was investigat
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 43:592-594
Autor:
Gerhard Eisenbrand, Jochen Christ, Stefan Wölfl, Sandra Vatter, Karl-Heinz Merz, Xinlai Cheng
Publikováno v:
Bioorganicmedicinal chemistry. 22(1)
Aza- and diaza-bisindoles were synthesized by coupling of 7-azaisatin, 7-azaoxindol, 7-azaindoxyl acetate, and their non-aza counterparts, respectively. Whereas 7,7'-diazaindigo (10) and 7,7'-diazaisoindigo (11) did not show antiproliferative activit
Publikováno v:
Bioorganicmedicinal chemistry. 18(12)
Indirubins have been reported to act as potent inhibitors of protein kinases relevant to tumorigenesis and of tumor cell growth, but their development to antitumor drugs suffer from their poor water solubility. We synthesized a novel class of indirub
Autor:
Sandra Vatter, H. Konig, D. Kim, R. Buettner, Prokopios Magiatis, Gerhard Eisenbrand, K. H. Merz, S. Park, X. Liu, J. Turkson, J. Q. Cheng, AL Skaltsounis, Richard Jove, S Nam, F. Hippe, R. Bhatia, S. Muehlbeyer
Publikováno v:
Planta Medica. 74
Publikováno v:
International journal of clinical pharmacology and therapeutics. 43(12)