Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sandra Ueberberg"'
Autor:
Andrea Tannapfel, Waldemar Uhl, Juris J. Meier, Sandra Ueberberg, Michael A. Nauck, Chiara Montemurro, Anne Clark
Publikováno v:
The Journal of clinical endocrinology and metabolism. 105(8)
Background Amyloid deposits are a typical finding in pancreatic islets from patients with type 2 diabetes. Whether this is linked to the pathogenesis of type 2 diabetes is currently unknown. Therefore, we compared the occurrence of islet amyloid in p
Autor:
Hendrik Jütte, Michael A. Nauck, Juris J. Meier, Eduard Montanya, Sandra Ueberberg, Waldemar Uhl, Wolfgang E. Schmidt, Andrea Tannapfel
Publikováno v:
Diabetes, Obesity and Metabolism. 18:1253-1262
Aims/hypothesis Incretin-based therapies have been associated with an increased risk of pancreatitis. Recently, various histological abnormalities have been reported in human pancreatic tissue from brain-dead organ donors that had been exposed to inc
Autor:
Andrea Tannapfel, Bjoern A. Menge, Thomas G. K. Breuer, Waldemar Uhl, Sandra Ueberberg, Kirsten Kampmann, Juris J. Meier
Publikováno v:
Metabolism. 65:84-91
The gastrointestinal hormone GLP-1 is released from enteroendocrine L-cells and augments postprandial insulin secretion. In patients with type 2 diabetes, the incretin effect is markedly diminished. It is unclear, whether this is due to a reduction i
Autor:
Juris J. Meier, Sandra Ueberberg, Stephan Schneider, Waldemar Uhl, Peter Schenker, Andrea Tannapfel, Richard Viebahn
Publikováno v:
Metabolism: clinical and experimental. 65(5)
The low frequency of beta-cell replication in the adult human pancreas limits beta-cell regeneration. A better understanding of the regulation of human beta-cell proliferation is crucial to develop therapeutic strategies aiming to enhance beta-cell m
Autor:
Timo Deutschbein, Harald Klein, Ralph Schirrmacher, Johannes W. Dietrich, Sara Akinturk, Stephan Schneider, Sandra Ueberberg, Nora Prochnow
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 301:E83-E90
Recently, we reported the generation of single-chain antibodies (SCAs) highly specific for rodent and human β-cells. Our current report describes the generation of a fusion protein of one of these SCAs (SCA B1) with a NF-κB essential modifier (NEMO
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 300:E717-E723
Impaired suppression of glucagon levels after oral glucose or meal ingestion is a hallmark of type 2 diabetes. Whether hyperglucagonemia after a β-cell loss results from a functional upregulation of glucagon secretion or an increase in α-cell mass
Autor:
Juris J. Meier, Andrea Tannapfel, Sandra Ueberberg, Manfred Köller, Carmen Waengler, Inge Schmitz, Johannes W. Dietrich, Ralf Schirrmacher, Stephan Schneider, Harald Klein, W. Schechinger
Publikováno v:
Diabetes
OBJECTIVE Noninvasive determination of pancreatic β-cell mass in vivo has been hampered by the lack of suitable β-cell–specific imaging agents. This report outlines an approach for the development of novel ligands homing selectively to islet cell
Autor:
Dávid Z, Balla, Sven, Gottschalk, G, Shajan, Sandra, Ueberberg, Stephan, Schneider, Matthias, Hardtke-Wolenski, Elmar, Jaeckel, Verena, Hoerr, Cornelius, Faber, Klaus, Scheffler, Rolf, Pohmann, Jörn, Engelmann
Publikováno v:
Contrast mediamolecular imaging. 8(6)
The purpose of this study was to investigate the potential of a novel targeted contrast agent (CA) for the in vivo visualization of single native pancreatic islets, the sites of insulin production, in the pancreas of mice using magnetic resonance ima
Autor:
W. Schechinger, Johannes W. Dietrich, S. Akinturk, David S. Ziegler, Stephan Schneider, H. H. Klein, Sandra Ueberberg
Publikováno v:
Diabetologia. 53(7)
The aim of the present study was to evaluate in vitro phage display in a beta cell line as a novel strategy for the isolation of beta cell-specific agents/biomarkers.A single-chain antibody (SCA) library was pre-incubated with AR42J cells in order to
Entwicklung eines β-Zell spezifischen Kontrastmittels zur nicht-invasiven Bestimmung der β-Zellmasse
Autor:
Stephan Schneider, Juris J. Meier, Inge Schmitz, Andrea Tannapfel, Manfred Köller, Ralf Schirrmacher, W. Schechinger, H. H. Klein, Sandra Ueberberg, Johannes W. Dietrich
Publikováno v:
Diabetologie und Stoffwechsel. 4