Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sandra Tong-Starksen"'
Autor:
Frederick W.K. Tam, James Tumlin, Jonathan Barratt, Brad H. Rovin, Ian S.D. Roberts, Candice Roufosse, H. Terence Cook, Gurjeet Bhangal, Alison L. Brown, Martin Busch, Fayaz Dudhiya, Anne-Marie Duliege, Donald J. Fraser, Daniel P. Gale, Chiu-Ching Huang, Ping-Chin Lai, Meng Lee, Esteban S. Masuda, Stephen P. McAdoo, Alexander R. Rosenkranz, Claudia Sommerer, Gere Sunder-Plassmann, Cheuk-Chun Szeto, Sydney C.W. Tang, Don E. Williamson, Lisa Willcocks, Volker Vielhauer, Min Jeong Kim, Leslie Todd, Hany Zayed, Sandra Tong-Starksen, Richard Lafayette
Publikováno v:
Kidney International Reports, Vol 8, Iss 12, Pp 2546-2556 (2023)
Introduction: We reported increased spleen tyrosine kinase (SYK) expression in kidney biopsies of patients with IgA nephropathy (IgAN) and that inhibition of SYK reduces inflammatory cytokines production from IgA stimulated mesangial cells. Methods:
Externí odkaz:
https://doaj.org/article/66982ca5bf66483cb14ee295eaf07526
Autor:
Sandra Tong-Starksen, Paul S. Lin, Brian L. West, Paul Severson, Xin Ye, Heather L. Gelhorn, Charles Peterfy, Henry H. Hsu, Eric Sherman, Fadi Braiteh, Andrew J. Wagner, Gregory M. Cote, Igor Puzanov, Zev A. Wainberg, Vicki L. Keedy, Geoffrey I. Shapiro, Allen Lee Cohn, Bartosz Chmielowski, John H. Healey, Chao Zhang, Mike Sterba, Stephen Patrick Anthony, Arun S. Singh, William D. Tap
Purpose:To assess the response to pexidartinib treatment in six cohorts of adult patients with advanced, incurable solid tumors associated with colony-stimulating factor 1 receptor (CSF1R) and/or KIT proto-oncogene receptor tyrosine kinase activity.P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c23a45df4ab5ad4ce47e4769969c45
https://doi.org/10.1158/1078-0432.c.6530892
https://doi.org/10.1158/1078-0432.c.6530892
Autor:
Sandra Tong-Starksen, Paul S. Lin, Brian L. West, Paul Severson, Xin Ye, Heather L. Gelhorn, Charles Peterfy, Henry H. Hsu, Eric Sherman, Fadi Braiteh, Andrew J. Wagner, Gregory M. Cote, Igor Puzanov, Zev A. Wainberg, Vicki L. Keedy, Geoffrey I. Shapiro, Allen Lee Cohn, Bartosz Chmielowski, John H. Healey, Chao Zhang, Mike Sterba, Stephen Patrick Anthony, Arun S. Singh, William D. Tap
Supplementary Data from Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e149a7afcdc68bbe63a27f167cc400b
https://doi.org/10.1158/1078-0432.22482318.v1
https://doi.org/10.1158/1078-0432.22482318.v1
Autor:
Paul S. Lin, Charles Peterfy, Andrew J. Wagner, John H. Healey, Mike Sterba, Gregory M. Cote, Paul Severson, Heather L. Gelhorn, Eric J. Sherman, Chao Zhang, Henry H. Hsu, Geoffrey I. Shapiro, Arun S. Singh, Sandra Tong-Starksen, Stephen P. Anthony, Bartosz Chmielowski, Fadi Braiteh, Allen Lee Cohn, Igor Puzanov, William D. Tap, Brian L. West, Vicki L. Keedy, Xin Ye, Zev A. Wainberg
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 28, iss 2
Purpose: To assess the response to pexidartinib treatment in six cohorts of adult patients with advanced, incurable solid tumors associated with colony-stimulating factor 1 receptor (CSF1R) and/or KIT proto-oncogene receptor tyrosine kinase activity.
Autor:
William D Tap, Hans Gelderblom, Emanuela Palmerini, Jayesh Desai, Sebastian Bauer, Jean-Yves Blay, Thierry Alcindor, Kristen Ganjoo, Javier Martín-Broto, Christopher W Ryan, David M Thomas, Charles Peterfy, John H Healey, Michiel van de Sande, Heather L Gelhorn, Dale E Shuster, Qiang Wang, Antoine Yver, Henry H Hsu, Paul S Lin, Sandra Tong-Starksen, Silvia Stacchiotti, Andrew J Wagner, on behalf of the ENLIVEN investigators†
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Lancet, 394(10197), 478-487. ELSEVIER SCIENCE INC
instname
Lancet, 394(10197), 478-487. ELSEVIER SCIENCE INC
ENLIVEN investigators.
[Background] Tenosynovial giant cell tumour (TGCT), a rare, locally aggressive neoplasm, overexpresses colony-stimulating factor 1 (CSF1). Surgery is standard with no approved systemic therapy. We aimed to evaluate pexidar
[Background] Tenosynovial giant cell tumour (TGCT), a rare, locally aggressive neoplasm, overexpresses colony-stimulating factor 1 (CSF1). Surgery is standard with no approved systemic therapy. We aimed to evaluate pexidar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fbb97926d3ef05247048cfb81ce296
http://hdl.handle.net/10261/201376
http://hdl.handle.net/10261/201376
Autor:
Zev A. Wainberg, Henry H. Hsu, Paul Severson, Chao Zhang, Sandra Tong-Starksen, William D. Tap, Brian L. West
Publikováno v:
Cancer Research. 80:2020-2020
Background: Tenosynovial giant cell tumors (TGCTs) are characterized by rearrangements of the colony-stimulating factor 1 (CSF1) gene. Dysregulated CSF1 may attract CSF1 receptor (CSF1R)-bearing mononuclear cells that form the bulk of the tumor. CSF1
Autor:
Pablo E. Pergola, Pearl Study Groups, Bruce Spinowitz, A.M. Duliege, Robert Provenzano, Steven Fishbane, Krishna R. Polu, Sandra Tong-Starksen, Iain C. Macdougall, Rebecca J. Schmidt, R. Zabaneh, Amit Sharma, Martha Mayo, Hong Tang
Publikováno v:
New England Journal of Medicine. 368:320-332
Background Peginesatide is a peptide-based erythropoiesis-stimulating agent (ESA) that may have therapeutic potential for anemia in patients with advanced chronic kidney disease. We evaluated the safety and efficacy of peginesatide, as compared with
Autor:
K. B. Nolop, Andrew J. Wagner, Gaston Habets, Igor Puzanov, Hoa Nguyen, Vicki L. Keedy, Stephen P. Anthony, Charles Peterfy, John H. Healey, Zev A. Wainberg, Marie J Kim, Arthur P Staddon, Laura Sanftner, Prabha N. Ibrahim, Brian L. West, Allen Lee Cohn, Matt van de Rijn, Paul Severson, Henry H. Hsu, Elizabeth A. Burton, Garson Tsang, Sandra Tong-Starksen, Glen J. Weiss, Adhirai Marimuthu, Gary Conard Visor, Carolyn Gee, William D. Tap, Arun S. Singh, Ramesh K. Ramanathan, Jiazhong Zhang, Eunice L. Kwak, Geoffrey I. Shapiro, Peter Hirth, Paul S. Lin, Gideon Bollag, Ying Zhang, Daniel D. Von Hoff, Chao Zhang, Rafe Shellooe, Bartosz Chmielowski
Publikováno v:
The New England journal of medicine. 373(5)
Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most tenosynovial giant-cell tumors. This observation has led to the discovery and clinical development of therapy targeting the CSF1 receptor (CSF1R).Using x-ray co-crystallogr