Výsledky vyhledávání - "Sandra Tillmann"

Akademický článek

ZL006, a small molecule inhibitor of PSD-95/nNOS interaction, does not induce antidepressant-like effects in two genetically predisposed rat models of depression and control animals.

Autor: Sandra Tillmann, Vitor Silva Pereira, Nico Liebenberg, Anne Karina Christensen, Gregers Wegener

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182698 (2017)

N-methyl-D-aspartate receptor (NMDA-R) antagonists and nitric oxide inhibitors have shown promising efficacy in depression but commonly induce adverse events. To circumvent these, a more indirect disruption of the nitric oxide synthase/postsynaptic d

Externí odkaz: https://doaj.org/article/8e939364e85848aaa92db44d56c09851

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The pan-JAK inhibitor delgocitinib in a cream formulation demonstrates dose response in chronic hand eczema in a 16-week randomized phase IIb trial

Autor: Margitta Worm, Jacob P. Thyssen, Sibylle Schliemann, Andrea Bauer, Vivian Y. Shi, Ben Ehst, Sandra Tillmann, Sofie Korn, Katarina Resen, Tove Agner

Publikováno v: Worm, M, Thyssen, J P, Schliemann, S, Bauer, A, Shi, V Y, Ehst, B, Tillmann, S, Korn, S, Resen, K & Agner, T 2022, ' The pan-JAK inhibitor delgocitinib in a cream formulation demonstrates dose response in chronic hand eczema in a 16-week randomized phase IIb trial ', British Journal of Dermatology, vol. 187, no. 1, pp. 42-51 . https://doi.org/10.1111/bjd.21037

Background: Chronic hand eczema (CHE) is a burdensome disease, and new well-documented, safe and efficacious treatments are warranted. In a recent CHE phase IIa trial, the pan-Janus kinase (JAK) inhibitor delgocitinib in an ointment formulation was f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8bbc00f1dd0f45ae07c5c9910cc329
https://curis.ku.dk/portal/da/publications/the-panjak-inhibitor-delgocitinib-in-a-cream-formulation-demonstrates-dose-response-in-chronic-hand-eczema-in-a-16week-randomized-phase-iib-trial(7c0271af-7803-4981-9820-a1ab75ccbce2).html

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Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats

Autor: Casper René Gøtzsche, Søren H. Christiansen, Sandra Tillmann, Moustapha Hassan, Aleksander A. Mathé, Gregers Wegener, Heidi E. Skibdal, David P.D. Woldbye

Publikováno v: Tillmann, S, Skibdal, H E, Christiansen, S H, Gøtzsche, C R, Hassan, M, Mathé, A A, Wegener, G & Woldbye, D P D 2019, ' Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats ', Behavioural Brain Research, vol. 367, pp. 28-34 . https://doi.org/10.1016/j.bbr.2019.03.039

Neuropeptide S (NPS) has shown anxiolytic-like effects in rodents after acute administration, but its long-term effects remain unknown. Gene therapy enables the targeted delivery of DNA to cell nuclei, and recombinant adeno-associated viral (rAAV) ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb918be00dc3d22fc5afbc68a0fd3424
https://doi.org/10.1016/j.bbr.2019.03.039

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Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression

Autor: Sandra Tillmann, Juergen Geisel, Per F. Mikkelsen, Gregers Wegener, Denise F. Happ, Rima Obeid

Publikováno v: Tillmann, S, Happ, D F, Mikkelsen, P F, Geisel, J, Wegener, G & Obeid, R 2019, ' Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression ', Behavioural Brain Research, vol. 364, pp. 274-280 . https://doi.org/10.1016/j.bbr.2019.02.011

Depression is associated with dysregulation of methyl group metabolism such as low S-adenosylmethionine (SAM). We previously reported that Flinders Sensitive Line (FSL) rats, an animal model of depression, had lower concentrations of liver SAM than t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329e88710f070c7ddee843db845548e0
https://doi.org/10.1016/j.bbr.2019.02.011

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The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics

Autor: Per Magne Ueland, Hussain M. Awwad, Giulia Treccani, Sandra Tillmann, Chad W. MacPherson, Denise F. Happ, Thomas A. Tompkins, Gregers Wegener, Rima Obeid, Juergen Geisel

Publikováno v: Tillmann, S, Awwad, H M, MacPherson, C W, Happ, D F, Treccani, G, Geisel, J, Tompkins, T A, Ueland, P M, Wegener, G & Obeid, R 2021, ' The kynurenine pathway is upregulated by methyl-deficient diet and changes are averted by probiotics ', Molecular Nutrition & Food Research, vol. 65, no. 9, 2100078, pp. e2100078 . https://doi.org/10.1002/mnfr.202100078
Molecular Nutrition & Food Research

Scope Probiotics exert immunomodulatory effects and may influence tryptophan metabolism in the host. Deficiency of nutrients related to C1 metabolism might stimulate inflammation by enhancing the kynurenine pathway. This study used Sprague Dawley rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6901d8260975ae41e28ff7bd8b3216

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Syringe-feeding as a novel delivery method for accurate individual dosing of probiotics in rats

Autor: Gregers Wegener, Sandra Tillmann

Publikováno v: Tillmann, S & Wegener, G 2018, ' Syringe-feeding as a novel delivery method for accurate individual dosing of probiotics in rats ', Beneficial Microbes, vol. 9, no. 2, pp. 311-315 . https://doi.org/10.3920/BM2017.0127

Probiotic administration to rodents is typically achieved using oral gavage or water bottles, but both approaches may compromise animal welfare, bacterial viability, dosing accuracy, or ease of administration. Oral gavage dosing may induce stress, es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91403f67fd65f5db76ffc35709893574
https://doi.org/10.3920/bm2017.0127

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Mind the gap – towards complete and transparent reporting of animal research

Autor: Sandra Tillmann

Publikováno v: Tillmann, S 2018, ' Mind the gap – towards complete and transparent reporting of animal research ', Medical Writing, vol. 26, no. 4, pp. 24-27 .
Sandra Tillmann
Aarhus University

Several initiatives have been taken to standardise the reporting of animal studies in peer-reviewed scientific journals, such as the ARRIVE (Animal Research: Reporting of In Vivo Experiments) and GSPC (Gold Standard Publication Checklist) guidelines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::657c6a3efcf8be5127e8f6bcee7809b6
https://pure.au.dk/portal/da/publications/mind-the-gap--towards-complete-and-transparent-reporting-of-animal-research(32927f76-f38c-4940-8008-6c7b2b8c2b6c).html

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Altered fecal microbiota composition in the Flinders Sensitive Line rat model of depression

Autor: Anders Abildgaard, Sandra Tillmann, Gudrun Winther, Gregers Wegener

Publikováno v: Tillmann, S, Abildgaard, A, Winther, G & Wegener, G 2019, ' Altered fecal microbiota composition in the Flinders Sensitive Line rat model of depression ', Psychopharmacology, vol. 236, no. 5, pp. 1445-1457 . https://doi.org/10.1007/s00213-018-5094-2
Psychopharmacology

Rationale The gut microbiota is increasingly recognized as a potential mediator of psychiatric diseases. Depressed patients have been shown to have a different microbiota composition compared with healthy controls, and several lines of research now a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8f89ec1f6ee141f170bf213460e059
https://pure.au.dk/ws/files/197692772/Tillmann2019_Article_AlteredFecalMicrobiotaComposit.pdf

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Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression

Autor: Sandra Tillmann, Gregers Wegener

Publikováno v: Tillmann, S & Wegener, G 2019, ' Probiotics reduce risk-taking behavior in the Elevated Plus Maze in the Flinders Sensitive Line rat model of depression ', Behavioural Brain Research, vol. 359, pp. 755-762 . https://doi.org/10.1016/j.bbr.2018.08.025

Several studies have reported beneficial effects of probiotics on behavior and stress in humans and animals. The multi-strain probiotic product Ecologic® Barrier has shown antidepressant-like effects in rats when given in combination with high-fat d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1320ceeee023f03e7ea5dabac0ea0246
https://pubmed.ncbi.nlm.nih.gov/30170032

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