Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sandra Spieß"'
Autor:
Diana Ezhkova, Simone Schwarzer, Sandra Spieß, Michaela Geffarth, Anja Machate, Daniela Zöller, Johanna Stucke, Dimitra Alexopoulou, Mathias Lesche, Andreas Dahl, Stefan Hans
Publikováno v:
Biology Open, Vol 12, Iss 6 (2023)
Externí odkaz:
https://doaj.org/article/74e81f6243ee4cb18fb1c811a151d13e
Autor:
Stefan Hans, Daniela Zöller, Juliane Hammer, Johanna Stucke, Sandra Spieß, Gokul Kesavan, Volker Kroehne, Juan Sebastian Eguiguren, Diana Ezhkova, Andreas Petzold, Andreas Dahl, Michael Brand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Targeting a gene with two loxP sites is both time and labour intensive. Here the authors present Cre-Controlled CRISPR allowing conditional mutagenesis of a gene of interest and simultaneously labelling the putative mutant cells fluorescently.
Externí odkaz:
https://doaj.org/article/0ca98762369949e99a34f959a12b3002
Autor:
Simone Schwarzer, Devavrat Ravindra Rekhade, Anja Machate, Sandra Spieß, Michaela Geffarth, Diana Ezhkova, Stefan Hans
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Sensorineural hearing loss is caused by the loss of sensory hair cells and/or their innervating neurons within the inner ear and affects millions of people worldwide. In mammals, including humans, the underlying cell types are only produced during fe
Externí odkaz:
https://doaj.org/article/f547550daffe4633a6bc5e7b50fb9a23
Autor:
Stefano Suzzi, Reiner Ahrendt, Stefan Hans, Svetlana A Semenova, Avinash Chekuru, Paul Wirsching, Volker Kroehne, Saygın Bilican, Shady Sayed, Sylke Winkler, Sandra Spieß, Anja Machate, Jan Kaslin, Pertti Panula, Michael Brand
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009794 (2021)
LRRK2 gain-of-function is considered a major cause of Parkinson's disease (PD) in humans. However, pathogenicity of LRRK2 loss-of-function in animal models is controversial. Here we show that deletion of the entire zebrafish lrrk2 locus elicits a ple
Externí odkaz:
https://doaj.org/article/66a7d68b5aa74d34a2b220b852048894
Publikováno v:
Biology Open, Vol 6, Iss 9, Pp 1270-1278 (2017)
Morpholino-mediated knockdown has shown that the homeodomain transcription factors Dlx3b and Dlx4b are essential for proper induction of the otic-epibranchial progenitor domain (OEPD), as well as subsequent formation of sensory hair cells in the deve
Externí odkaz:
https://doaj.org/article/713ab8e52c8b4faba003aaf7e673cede
Autor:
Shady Sayed, Jan Kaslin, Stefano Suzzi, Volker Kroehne, Stefan Hans, Pertti Panula, Paul Wirsching, Sandra Spieß, Anja Machate, Saygin Bilican, Sylke Winkler, Avinash Chekuru, Michael Brand, Reiner Ahrendt, Svetlana Semenova
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009794 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009794 (2021)
LRRK2 gain-of-function is considered a major cause of Parkinson’s disease (PD) in humans. However, pathogenicity of LRRK2 loss-of-function in animal models is controversial. Here we show that deletion of the entire zebrafish lrrk2 locus elicits a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b433f543f7ad522ab4d4c5317fc4c0
Autor:
Juan Sebastian Eguiguren, Stefan Hans, Juliane Hammer, Michael Brand, Volker Kroehne, Sandra Spieß, Andreas Dahl, Diana Ezhkova, Andreas Petzold, Johanna Stucke, Daniela Zöller, Gokul Kesavan
Conditional gene inactivation is a powerful tool to determine gene function when constitutive mutations result in detrimental effects. The most commonly used technique to achieve conditional gene inactivation employs the Cre/loxP system and its abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::837715378dfdb1cd217b23c77a8de97a
https://doi.org/10.21203/rs.3.rs-72885/v1
https://doi.org/10.21203/rs.3.rs-72885/v1
Publikováno v:
Biology Open
Biology Open, Vol 6, Iss 9, Pp 1270-1278 (2017)
Biology Open, Vol 6, Iss 9, Pp 1270-1278 (2017)
Morpholino-mediated knockdown has shown that the homeodomain transcription factors Dlx3b and Dlx4b are essential for proper induction of the otic-epibranchial progenitor domain (OEPD), as well as subsequent formation of sensory hair cells in the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350b710f782741a3d2621c8b87432e45
http://europepmc.org/articles/PMC5612237
http://europepmc.org/articles/PMC5612237
Autor:
Shady Sayed, Stefan Hans, Pertti Panula, Sandra Spieß, Jan Kaslin, Sylke Winkler, Svetlana Semenova, Reiner Ahrendt, Stefano Suzzi, Saygin Bilican, Michael Brand
Publikováno v:
bioRxiv
LRRK2 mutations are a major cause of Parkinson’s disease. Pathogenicity of LRRK2 loss-of-function is controversial, as knockout in rodents reportedly induces no brain-specific effects and knockdown studies in zebrafish are conflicting. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a339ddad588566f512ec2670d52996