Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sandra Snook"'
Autor:
Jerry F. Hardisty, Jing Ying Ma, Williams D Kerns, Samuel M. Cohen, Andrew M Standeven, Sandra Snook, Vinicius Carreira
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 180(1)
Two young cynomolgus macaques (Macaca fascicularis) given a small molecule kinase inhibitor ((S)-4-((2–(5-chloro-2-fluorophenyl)-5-isopropylpyrimidin-4-yl)amino)-N-(2-hydroxypropyl)nicotinamide [SCIO-120]) via nasogastric intubation gavage, once-da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d840d63c2b8dd4b764b8e976c797fd
https://pubmed.ncbi.nlm.nih.gov/33483736
https://pubmed.ncbi.nlm.nih.gov/33483736
Publikováno v:
International Journal of Toxicology. 36:386-394
Immunohistochemical staining for the lysosome-associated membrane protein 2 (LAMP-2) has been proposed previously as an alternative to electron microscopy to identify hepatic phospholipidosis. This study used LAMP-2 immunohistochemistry (IHC) to diag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1379d5ac339c41dd0fce612ae33d3785
https://doi.org/10.1177/1091581817726040
https://doi.org/10.1177/1091581817726040
Autor:
Diane Hamlin, L. Nguyen, Yafei Chen, Karen M. Lynch, Manisha Sonee, Michele C. Rizzolio, Sandra Snook, Jing Ying Ma, S. Lee, James Eric McDuffie
Publikováno v:
Toxicology Research. 5:1202-1215
This 10-day (D) study was conducted to evaluate changes in traditional and newer kidney safety biomarker expression levels in dogs. Animals received cisplatin (CDDP, 0.75 mg per kg per day) or 0.9% Saline (vehicle) for 5 days. Serum/urine samples wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ead2206eea1faaf31dd2ce43e16c3ef
https://doi.org/10.1039/c5tx00497g
https://doi.org/10.1039/c5tx00497g
Autor:
Matthew Wagoner, Buck W, Karen M. Lynch, Marshall K, Manisha Sonee, Letitia Cheatham, Kinter Lb, James Eric McDuffie, Dragan Yp, Klapczynski M, Damour M, Yang Y, Eisinger D, Sandra Snook, Sace F, Jing Ying Ma, Fikes J, Stephen L, Yafei Chen
Publikováno v:
Current Topics in Medicinal Chemistry. 17
Urinary protein biomarkers and metabolomic markers have been leveraged to detect acute Drug Induced Kidney Injury (DIKI) in rats; however, the utility of these indicators to enable early detection of DIKI in canine models has not been well documented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee104e9d34c80a5cec6be7dca8e01831
https://doi.org/10.2174/1568026617666170713172331
https://doi.org/10.2174/1568026617666170713172331
Autor:
J. Eric McDuffie, Sandra Snook, Yunhai Zhang, Ke Li, Ryan Meng, Jing Ying Ma, Manisha Sonee, Michele C. Rizzolio, Frederic S Almy, Xiaoyun Wu
Publikováno v:
The Journal of toxicological sciences. 42(2)
Amphotericin B (AmpB) nephrotoxicity was used to assess the utility of drug‑induced kidney injury (DIKI) biomarkers in an exploratory study in male cynomolgus monkeys. All animals had quantifiable levels of AmpB in plasma on days 1 and 4. There wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d286e10a27b1e1fe9496c3ccde8b701e
https://pubmed.ncbi.nlm.nih.gov/28321043
https://pubmed.ncbi.nlm.nih.gov/28321043
Autor:
Robin L, Thurmond, Jennifer, Venable, Brad, Savall, David, La, Sandra, Snook, Paul J, Dunford, James P, Edwards
Publikováno v:
Handbook of experimental pharmacology. 241
The discovery of the histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31e875b056dfeafc40c9f0506765f5aa
https://pubmed.ncbi.nlm.nih.gov/28233185
https://pubmed.ncbi.nlm.nih.gov/28233185
Autor:
Brad M. Savall, Paul J. Dunford, James P. Edwards, David La, Sandra Snook, Jennifer Venable, Robin L. Thurmond
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783319581927
The discovery of the histamine H4 receptor (H4R) provided a new avenue for the exploration of the physiological role of histamine, as well as providing a new drug target for the development of novel antihistamines. The first step in this process was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a2481327f1dd586f254551076f6775
https://doi.org/10.1007/164_2016_130
https://doi.org/10.1007/164_2016_130
Autor:
Bianca Feyen, Sandra De Jonghe, Calvert Louden, Petra Vinken, Stewart Bryant, Godelieve Lammens, Rao N.V.S. Mamidi, Sandra Snook, Mark D. Johnson, Esther Moesen, Michael F. Kelley, Jim Proctor, Kirk Ways, Jing Ying Ma
Publikováno v:
Chemico-Biological Interactions. 221:109-118
Canagliflozin is an SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus. Studies were conducted to investigate the mechanism responsible for renal tubular tumors and pheochromocytomas observed at the high dose in a 2-year carcinogenici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdbd8bc2e8d924de0a09868d12596d2
https://doi.org/10.1016/j.cbi.2014.08.001
https://doi.org/10.1016/j.cbi.2014.08.001
Autor:
Calvert Louden, Manisha Sonee, James Eric McDuffie, Sandra Snook, Antonio Guy, Xuejun Liu, Marciano Sablad, Lynn Varacallo, David La, Jennifer Vegas, Jing Ying Ma
Publikováno v:
International Journal of Toxicology. 32:251-260
Cisplatin (CDDP) is known to produce renal proximal tubule injury. Various renal biomarkers have been related to CDDP nephrotoxicity in previous research, but the temporal and spatial relationship of these biomarkers to injury reversal has not been w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e29c33d1ed43c8e3dab0f74d7fd2df
https://doi.org/10.1177/1091581813493013
https://doi.org/10.1177/1091581813493013
Publikováno v:
The Journal of toxicological sciences. 41(4)
To date, eight next‑generation urinary protein kidney safety biomarkers have been qualified to enable monitoring for subclinical drug‑induced kidney injury (DIKI) in rat preclinical studies; however, most DIKI biomarker studies have included only
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5580edb71d5fa88425da7a334d80441b
https://pubmed.ncbi.nlm.nih.gov/27432232
https://pubmed.ncbi.nlm.nih.gov/27432232