Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sandra Sivilia"'
Autor:
Nozha Borjini, Sandra Sivilia, Alessandro Giuliani, Mercedes Fernandez, Luciana Giardino, Fabrizio Facchinetti, Laura Calzà
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-18 (2019)
Abstract Background Hypoxic-ischemic (HI) encephalopathy causes life-long morbidity and premature mortality in term neonates. Therapies in addition to whole-body cooling are under development to treat the neonate at risk for HI encephalopathy, but ar
Externí odkaz:
https://doaj.org/article/78d54d3ca7f44afd8bd7ab9cfff9e592
Autor:
Marco Gusciglio, Luciana Giardino, Laura Calzà, Sandra Sivilia, Michele Sannia, Vito Antonio Baldassarro, Luca Lorenzini, Alessandro Giuliani
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 78:101-112
We describe age-related histological structure and molecular changes of the neurovascular unit (NVU) in the cerebral cortex of Tg2576 and age-matched wild-type (WT) mice. Major results can be summarized as follows: (i) β-amyloid (6E10)-immunoreactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a89214a4c94913702562ad530e095b6
https://doi.org/10.1093/jnen/nly125
https://doi.org/10.1093/jnen/nly125
Autor:
Fabrizio Facchinetti, Nozha Borjini, Alessandro Giuliani, Sandra Sivilia, Mercedes Fernandez, Luciana Giardino, Laura Calzà
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-18 (2019)
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-18 (2019)
Background Hypoxic-ischemic (HI) encephalopathy causes life-long morbidity and premature mortality in term neonates. Therapies in addition to whole-body cooling are under development to treat the neonate at risk for HI encephalopathy, but are not a q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34df0efab5f4051fe40b6091328d4d11
https://pubmed.ncbi.nlm.nih.gov/31660990
https://pubmed.ncbi.nlm.nih.gov/31660990
Publikováno v:
Glia. 64:1573-1589
Differentiation of oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes is severely impaired by inflammatory cytokines and this could lead to remyelination failure in inflammatory/demyelinating diseases. Due to the role of thyroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18243e9d5660bde4127fee08645773eb
https://doi.org/10.1002/glia.23025
https://doi.org/10.1002/glia.23025
Autor:
Alessandro Giuliani, Bruno P. Imbimbo, Laura Calzà, Luciana Giardino, Sandra Sivilia, Luca Ferraro, Luca Lorenzini, Tiziana Antonelli, Sarah Beggiato
Publikováno v:
Neuroscience. 266:13-22
CHF5074 is a nonsteroidal anti-inflammatory derivative that has been shown to inhibit β-amyloid plaque deposition and to reverse memory deficit in vivo in transgenic mouse models of Alzheimer's disease (AD). In the present in vivo study we used pre-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35e24d9b4f370b4758d1d7e9af58e50
https://doi.org/10.1016/j.neuroscience.2014.01.065
https://doi.org/10.1016/j.neuroscience.2014.01.065
Autor:
Marco Gusciglio, Marco Alessandri, Alessandro Giuliani, Chiara Mangano, Mercedes Fernandez, Vito Antonio Baldassarro, Laura Calzà, Luciana Giardino, Roberta Torricella, Sandra Sivilia, Luca Lorenzini
Publikováno v:
Current Topics in Medicinal Chemistry. 13:1843-1852
The drug discovery for disease-modifying agents in Alzheimer disease (AD) is facing a failure of clinical trials with drugs based on two driving hypotheses, i.e. the cholinergic and amyloidogenic hypotheses. In this article we recapitulate the main a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::624336ea730287b489d13a681f632959
https://doi.org/10.2174/15680266113139990140
https://doi.org/10.2174/15680266113139990140
Autor:
Luca Lorenzini, Alessandro Giuliani, Sandra Sivilia, Vito Antonio Baldassarro, Mercedes Fernandez, Matteo Lotti Margotti, Luciana Giardino, Vania Fontani, Salvatore Rinaldi, Laura Calzà
Publikováno v:
Scientific Reports
The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52f027f7153548e9488fc74275b26d6
https://doi.org/10.1038/srep37483
https://doi.org/10.1038/srep37483
Autor:
Luciana Giardino, Alessandro Giuliani, Salvatore Rinaldi, Vania Fontani, Luca Lorenzini, Mercedes Fernandez, Matteo Lotti Margotti, Sandra Sivilia, Laura Calzà, Vito Antonio Baldassarro
The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnologies play an important role. Here, it is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c724b1b7b7f0863524fe75c34fd322dc
http://hdl.handle.net/11585/596715
http://hdl.handle.net/11585/596715
Autor:
Marina Pizzi, Claudia Balducci, Luciana Giardino, Alessandro Usiello, Arturo R. Viscomi, Gino Villetti, Giuseppe Nisticò, Bruno P. Imbimbo, Annamaria Lanzillotta, Gianluigi Forloni, Luca Lorenzini, Alessandro Giuliani, Ilenia Sarnico, Lydia Mare, Simone Ottonello, Sandra Sivilia, Laura Calzà, Bisan Mehdawy, Robert Nisticò
Publikováno v:
Journal of Alzheimer's Disease. 24:799-816
Abnormal amyloid-β (Aβ) production and deposition is believed to represent one of the main causes of Alzheimer's disease (AD). γ-Secretase is the enzymatic complex responsible for Aβ generation from its precursor protein. Inhibition or modulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8f1103c9c24466a143010744ae02fb
https://doi.org/10.3233/jad-2011-101839
https://doi.org/10.3233/jad-2011-101839
Autor:
Sandra Sivilia, Luciana Giardino, Laura Calzà, Michela Paradisi, G. D’Intino, Mercedes Fernandez, G. Del Vecchio
Publikováno v:
Journal of Neurochemistry. 115:897-909
J. Neurochem. (2010) 115, 897–909. Abstract Polychlorinated dibenzo-dioxins, furans and dioxin-like polychlorinated biphenyls are ubiquitous in foodstuffs of animal origin and accumulate in the fatty tissues of animals and humans. The most toxic co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc3dbce1e3d276145d656adafb5b6440
https://doi.org/10.1111/j.1471-4159.2010.06974.x
https://doi.org/10.1111/j.1471-4159.2010.06974.x