Výsledky vyhledávání - "Sandra Sinishtaj"

Diastereoselective scalable synthesis of 2,6-trans-Piperidines using an aza-Michael reaction

Autor: Gopal Sirasani, Sandra Sinishtaj, Florine Collin, Jacek G. Martynow, He Zhao, Vinay V. Thakur, Erin M. Duffy, Chowdhury Somenath, Jianmin Mao, Yuanqing Tang, Ashoke Bhattacharjee, Yusheng Wu

Publikováno v: Tetrahedron Letters. 60:371-374

Highly efficient substrate and reagent controlled stereoselective synthesis of 2,6-trans-piperidine derivative (1) using an aza-Michael reaction is reported. This method was utilized to synthesize a variety of trans-piperidines on hundred-gram scales

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c514f5536e06890d4bae68556d90811
https://doi.org/10.1016/j.tetlet.2018.12.061

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Malaria-Infected Mice Are Cured by Oral Administration of New Artemisinin Derivatives

Autor: Remo Stohler, Reto Brun, Lindsey Catherine Hess, Sandra Sinishtaj, Alvin S. Kalinda, Aimee R. Usera, Kimberly S. Petersen, John G. D'angelo, Gary H. Posner, Theresa A. Shapiro, Andrew S. Rosenthal, Josefina Santo-Tomas, William A. Maio, Christopher Snyder, Sergio Wittlin, Jacques Chollet, Matthias Rottmann, Lauren E. Woodard, Wonsuk Chang

Publikováno v: Journal of Medicinal Chemistry. 51:1035-1042

In four or five chemical steps from the 1,2,4-trioxane artemisinin, a new series of 23 trioxane dimers has been prepared. Eleven of these new trioxane dimers cure malaria-infected mice via oral dosing at 3 x 30 mg/kg. The clinically used trioxane dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e16abd7fbd9eace1ec0df664837f2f
https://doi.org/10.1021/jm701168h

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Potent, Selective and Low-Calcemic Inhibitors of CYP24 Hydroxylase: 24-Sulfoximine Analogues of the Hormone 1α,25-Dihydroxyvitamin D3

Autor: Sara Peleg, Galina Bernstein, Patrick M. Dolan, Gary H. Posner, Mehmet Kahraman, Thomas W. Kensler, Samuel S. Chuang, Uttam Saha, Sandra Sinishtaj, Bozena Korczak

Publikováno v: Journal of Medicinal Chemistry. 47:6854-6863

A dozen 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3) were prepared, differing not only at the stereogenic sulfoximine stereocenter but also at the A-ring. Although these sulfoximines were not active transcriptionally and we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4eb7abaa60432f8d5115d42eed1795d5
https://doi.org/10.1021/jm040129+

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Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1alpha,25-dihydroxyvitamin D3

Autor: Gary H. Posner, Patrick M. Dolan, Sandra Sinishtaj, Thomas W. Kensler, Heung Bae Jeon

Publikováno v: Bioorganicmedicinal chemistry. 14(18)

Four new side-chain amide (2 and 3) and hydroxamate (4 and 5) analogs of the hormone calcitriol (1) have been prepared. Even though lacking the 25-OH group characteristic of natural calcitriol (1), analogs 2-4 are as antiproliferative in vitro as cal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a979c148a473208063fa19bc0f25db67
https://pubmed.ncbi.nlm.nih.gov/16765598

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Use of Bis-(chiral α-methylbenzyl)glycine Esters for Synthesis of Enantiopure β-Hydroxyamino Esters

Autor: Ayako Yamashita, R. Thomas Williamson, Douglas M. Ho, Sandra Sinishtaj, Tarek S. Mansour, Emily B. Norton

Publikováno v: ChemInform. 34

[reaction: see text] Aldol reactions using bis-(chiral alpha-methylbenzyl)glycine esters with aldehydes gave excellent diastereoselectivity. Thus, an enantiopure ribosylglycine was prepared for the synthesis of analogues of the natural antibiotics mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d099806cdf598fea4c66e731acec7cdd
https://doi.org/10.1002/chin.200350043

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