Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Sandra Siehler"'
Autor:
Paul J Groot-Kormelink, Sandrine Ferrand, Nicholas Kelley, Anke Bill, Felix Freuler, Pierre-Eloi Imbert, Anthony Marelli, Nicole Gerwin, Lucia G Sivilotti, Loren Miraglia, Anthony P Orth, Edward J Oakeley, Ulrich Schopfer, Sandra Siehler
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163129 (2016)
High throughput random mutagenesis is a powerful tool to identify which residues are important for the function of a protein, and gain insight into its structure-function relation. The human muscle nicotinic acetylcholine receptor was used to test wh
Externí odkaz:
https://doaj.org/article/edc60f1ecaf94064b4c4ecc0a4b3deed
Autor:
Sandra Siehler, Graeme Milligan
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane di
Autor:
David A. Sykes, Steven J. Charlton, Felix Freuler, Lukas Leder, Sandra Siehler, Ulrich Schopfer, Myriam Duckely, Cédric Fiez-Vandal
Publikováno v:
Biophysical Chemistry. :56-61
To broaden the use of the recombinant high-density lipoprotein (rHDL) approach to the characterization of lead compounds, we investigated the pharmacology of the human beta-2-adrenoceptor in nanolipid bilayers (rHDL) with a broad set of beta-adrenoce
Autor:
Sandra Siehler
Publikováno v:
British Journal of Pharmacology. 158:41-49
G protein-coupled receptors (GPCRs) represent a large family of seven transmembrane receptors, which communicate extracellular signals into the cellular lumen. The human genome contains 720-800 GPCRs, and their diverse signal characteristics are dete
Publikováno v:
Journal of Cellular Biochemistry. 104:1660-1670
G protein-coupled receptors (GPCRs) are important targets for medicinal agents. Four different G protein families, G(s), G(i), G(q), and G(12), engage in their linkage to activation of receptor-specific signal transduction pathways. G(12) proteins we
Autor:
Sandra Siehler, Danilo Guerini
Publikováno v:
Journal of Receptors and Signal Transduction. 26:549-575
To elucidate the physiological function of sphingosine 1-phosphate receptors 1-3 (S1P1-3) we aimed to identify selective ligands for these GPCRs. S1P2 and S1P3 are coupled to Gq, and are, therefore, linked to the phospholipase C/IP3/calcium pathway.
Publikováno v:
Autonomic and Autacoid Pharmacology. 25:1-16
Summary 1 The fish somatostatin receptor 3 (fsst3) is one of the few somatostatin (SRIF) receptors cloned from a non-mammalian species so far. Here we extended our earlier characterization of this receptor by investigating the guanine nucleotide sens
Publikováno v:
Journal of Biological Chemistry. 276:48733-48739
Sphingosine 1-phosphate (S1P) exerts a variety of actions as a second messenger or as an agonist that binds to one or more members of the Edg family of G protein-coupled receptors. By using human embryonic kidney 293 cells, we show that S1P activates
Publikováno v:
Molecular Pharmacology. 59:1269-1276
The antiepileptic drug valproic acid (VPA) is teratogenic, because it induces birth defects in some children of mothers treated for epilepsy. Cellular and molecular actions associated with teratogenicity were identified by testing differentiation of
Autor:
Sandra Siehler, Günther K.H. Zupanc, Eugenia M.C. Jones, Klaus Seuwen, Daniel Hoyer, Hiroto Furuta, Hideki Yano
Publikováno v:
General and Comparative Endocrinology. 115:333-345
The actions of the various forms of somatostatin (SRIF), including those of the tetradecapeptide SRIF(14), are mediated by specific receptors. In mammals, five subtypes of SRIF receptors, termed sst(1-5), have been cloned. Using a combination of reve