Expression of toll like receptor 8 (TLR8) in specific groups of mouse hippocampal interneurons.

Autor: Lennart Seizer, Sadegh Rahimi, Sandra Santos-Sierra, Meinrad Drexel

Publikováno v: PLoS ONE, Vol 17, Iss 5, p e0267860 (2022)

Toll-like receptors (TLR) are one of the main constituents of the innate immune system in mammals. They can detect conserved microbial structures (pathogen-associated molecular patterns) and host-derived ligands that are produced during cellular stre

Externí odkaz: https://doaj.org/article/e3c54f33418747b593ec431219d938c2

Developments in anticancer vaccination: budding new adjuvants

Autor: Sandra Santos-Sierra

Publikováno v: Biological Chemistry. 401:435-446

The immune system has a limited capacity to recognize and fight cells that become cancerous and in cancer patients, the immune system has to seek the right balance between cancer rejection and host-immunosupression. The tumor milieu builds a protecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebf42139d12109ec57cfcc5ac2efec6
https://doi.org/10.1515/hsz-2019-0383

Anti-inflammatory activity of small-molecule antagonists of Toll-like receptor 2 (TLR2) in mice

Autor: Sandra Santos-Sierra, M. Trieb, G. Wietzorrek, Meinrad Drexel

Publikováno v: Immunobiology. 224:1-9

Toll-like receptor 2 (TLR2) is currently investigated as a potential therapeutic target in diseases with underlying inflammation like sepsis and arthritis. We reported the discovery, by virtual screening and biological testing, of eight TLR2 antagoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be97e35e70c6e382c9b239b8df53a1bb
https://doi.org/10.1016/j.imbio.2018.11.004

Enhanced immunostimulatory activity of in silico discovered agonists of Toll-like receptor 2 (TLR2)

Autor: Sandra Santos-Sierra, Gerhard Wolber, Christin Rakers, P. Hörtnagl, Manuela S. Murgueitio, Philipp Henneke, Ramona S Bruckner, S. Ebner

Publikováno v: Biochimica et biophysica acta. General subjects. 1861(11 Pt)

Background Emergent therapies in anticancer vaccination use Toll-like receptors (TLRs) agonists as dendritic cell (DC) vaccine adjuvants. DCs from the patient are isolated, stimulated with TLR agonists and tumor antigens ex vivo and then infused back

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fce33ffdedf8e54009938941d1de69d
https://pubmed.ncbi.nlm.nih.gov/28734965

Insulin Modulates the Inflammatory Granulocyte Response to Streptococci via Phosphatidylinositol 3-Kinase

Autor: Sandra Santos-Sierra, Julius von Süßkind-Schwendi, Timo K. van den Berg, Monika Haeffner, Sachin D. Deshmukh, Antigoni Triantafyllopoulou, Sebastian Fuchs, Philipp Henneke, Susan Farmand, Julia Wennekamp, Jochen Seufert, Miriam Mergen, Taco W. Kuijpers, Sybille Kenzel

Publikováno v: Kenzel, S, Mergen, M, von Süßkind-Schwendi, J, Wennekamp, J, Deshmukh, S D, Haeffner, M, Triantafyllopoulou, A, Fuchs, S, Farmand, S, Santos-Sierra, S, Seufert, J, van den Berg, T K, Kuijpers, T W & Henneke, P 2012, ' Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase ', Journal of Immunology, vol. 189, no. 9, pp. 4582-91 . https://doi.org/10.4049/jimmunol.1200205
Journal of Immunology, 189(9), 4582-91. American Association of Immunologists
Journal of immunology (Baltimore, Md., 189(9), 4582-4591. American Association of Immunologists

Group B streptococci (GBS; Streptococcus agalactiae) are a major cause of invasive infections in newborn infants and in patients with type 2 diabetes. Both patient groups exhibit peripheral insulin resistance and alterations in polymorphonuclear leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d20d3f60ee9d31ec5b162573a688751
https://doi.org/10.4049/jimmunol.1200205