Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sandra Rodrigues-Mascarenhas"'
Autor:
Davi Azevedo Ferreira, Anna Beatriz Araujo Medeiros, Mariana Mendonça Soares, Éssia de Almeida Lima, Gabriela Carolina Santos Lima de Oliveira, Mateus Bernardo da Silva Leite, Matheus Vieira Machado, José Augusto Ferreira Perez Villar, Leandro Augusto Barbosa, Cristoforo Scavone, Marcelo Tigre Moura, Sandra Rodrigues-Mascarenhas
Publikováno v:
Cells, Vol 13, Iss 18, p 1568 (2024)
Cardiotonic steroids are known to bind to Na+/K+-ATPase and regulate several biological processes, including the immune response. The synthetic cardiotonic steroid γ-Benzylidene Digoxin 8 (BD-8) is emerging as a promising immunomodulatory molecule,
Externí odkaz:
https://doaj.org/article/a7ce4a90f6704e5d80aadee548dacc03
Autor:
Amanda Costa Ayres Salmeron, Maria Beatriz Calado, Mateus da Silva Matias Antunes, Gabriel Rodrigues Da Silva, Deyse Cristina Madruga Carvalho, Beatriz Fernandes de Souza, Márcia Regina Piuvezam, Sandra Rodrigues-Mascarenhas
Publikováno v:
Biology, Medicine & Natural Product Chemistry, Vol 12, Iss 1, Pp 215-224 (2023)
Ouabain (OUA) is a cardiotonic steroid with an immunomodulatory and anti-inflammatory role in different experimental models. Currently, the potential antineoplastic effect of OUA has been studied, however, research is needed to better understand OUA
Externí odkaz:
https://doaj.org/article/5b76982c7aef4216a232f8f280ef41c0
Autor:
Deyse Cristina Madruga Carvalho, Poliana Gomes da Silva, Willyenne Marília Dantas, Severino Jefferson Ribeiro da Silva, Caroline Targino Alves da Silva, Elton José Ferreira Chaves, Demetrius Antônio Machado de Araújo, Ronaldo Nascimento de Oliveira, Sandra Rodrigues-Mascarenhas, Lindomar José Pena
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Zika virus (ZIKV) is an emerging arbovirus associated with neurological disorders. Currently, no specific vaccines or antivirals are available to treat the ZIKV infection. Ouabain, a cardiotonic steroid known as Na+/K+-ATPase inhibitor, has
Externí odkaz:
https://doaj.org/article/848e283bd4bc4101a29fb847c6a9c88b
Autor:
David Martín-Hernández, Irene L. Gutiérrez, Marta González-Prieto, Karina S. MacDowell, Javier Robledo-Montaña, Hiram Tendilla-Beltrán, Natalia Calleja-Rodríguez, Álvaro G. Bris, Cristina Ulecia-Morón, Beatriz Moreno, Javier R. Caso, Borja García-Bueno, Sandra Rodrigues-Mascarenhas, Ignacio Marín-Jiménez, Juan Carlos Leza, Luis Menchén
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The chronic inflammatory process that characterizes inflammatory bowel diseases (IBD) is mainly driven by T-cell response to microbial and environmental antigens. Psychological stress is a potential trigger of clinical flares of IBD, and sph
Externí odkaz:
https://doaj.org/article/edc521850f6e4ccab60422df1f7b17cc
Autor:
Jacqueline Alves Leite, Luiz Henrique Agra Cavalcante-Silva, Martina Raissa Ribeiro, Geovanni de Morais Lima, Cristoforo Scavone, Sandra Rodrigues-Mascarenhas
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Cardiotonic steroids are natural compounds that present many physiological and pharmacological functions. They bind Na+/K+-ATPase (NKA) modifying cellular ion concentration and trigger cell signaling mechanisms without altering ion balance. These ste
Externí odkaz:
https://doaj.org/article/4c2815db01524a62bea727637a9dcdbc
Autor:
Deyse C. M. Carvalho, Luiz Henrique Agra Cavalcante-Silva, Éssia de A. Lima, José G. F. M. Galvão, Anne K. de A. Alves, Priscilla R. O. Feijó, Luís E. M. Quintas, Sandra Rodrigues-Mascarenhas
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Cardiotonic steroids, such as ouabain and digoxin, are known to bind to Na+/K+-ATPase and to promote several biological activities, including anti-inflammatory activity. However, there are still no reports in the literature about inflammation and mar
Externí odkaz:
https://doaj.org/article/af0f7cf41ce64ca48768df943476bc38
Autor:
Luiz H. A. Cavalcante-Silva, Éssia de Almeida Lima, Deyse C. M. Carvalho, José M. de Sales-Neto, Anne K. de Abreu Alves, José G. F. M. Galvão, Juliane S. de França da Silva, Sandra Rodrigues-Mascarenhas
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/d896132b13024e03b7e64aac02792fd9
Autor:
Luiz H. A. Cavalcante-Silva, Éssia de Almeida Lima, Deyse C. M. Carvalho, José M. de Sales-Neto, Anne K. de Abreu Alves, José G. F. M. Galvão, Juliane S. de França da Silva, Sandra Rodrigues-Mascarenhas
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Since the discovery of ouabain as a cardiotonic steroid hormone present in higher mammals, research about it has progressed rapidly and several of its physiological and pharmacological effects have been described. Ouabain can behave as a stress hormo
Externí odkaz:
https://doaj.org/article/6c118a7f8f9147f18b578cf0476cd2b5
Autor:
Glaucia V. Faheina-Martins, Jacqueline Alves Leite, Bruna Braga Dantas, Cláudio G. Lima-Júnior, Mário L. A. A. Vasconcellos, Sandra Rodrigues-Mascarenhas, Demetrius A. M. Araújo
Publikováno v:
Mediators of Inflammation, Vol 2017 (2017)
Inflammatory response plays an important role not only in the normal physiology but also in pathologies such as cancers. The Morita-Baylis-Hillman adducts (MBHA) are a novel group of synthetic molecules that have demonstrated many biological activiti
Externí odkaz:
https://doaj.org/article/85c4d7294a3645cb98e909cc96143687
Autor:
Jacqueline Alves Leite, Anne Kaliery De Abreu Alves, José Guilherme Marques Galvão, Mariana Pires Teixeira, Luiz Henrique Agra Cavalcante-Silva, Cristoforo Scavone, Alexandre Morrot, Vivian Mary Rumjanek, Sandra Rodrigues-Mascarenhas
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Ouabain, a potent inhibitor of the Na+, K+-ATPase, was identified as an endogenous substance. Recently, ouabain was shown to affect various immunological processes. We have previously demonstrated the ability of ouabain to modulate inflammation, but
Externí odkaz:
https://doaj.org/article/f2278b2a920e426994a96e9de42505fa