Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Sandra Roche"'
Autor:
Neil T Conlon, Sandra Roche, Amira F Mahdi, Alacoque Browne, Laura Breen, Johanna Gaubatz, Justine Meiller, Fiona O'Neill, Lorraine O'Driscoll, Mattia Cremona, Bryan T Hennessy, Lisa D Eli, John Crown, Denis M Collins
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102073- (2024)
Background: HER2-targeted therapies have revolutionised the treatment of HER2-positive breast cancer. However, de novo resistance or the emergence of acquired resistance is a persistent clinical problem. Here we report that neratinib, an irreversible
Externí odkaz:
https://doaj.org/article/80c2e8e9bf2e4172bafb263c57f5769f
Autor:
Sandra Roche, Christelle Yacou, Corine Jean Marius, Ronald Ranguin, Marckens Francoeur, Pierre-Louis Taberna, Nady Passe-Coutrin, Sarra Gaspard
Publikováno v:
Molecules, Vol 28, Iss 15, p 5882 (2023)
Since 2011, substantial amounts of pelagic Sargassum algae have washed up along the Caribbean beaches and the Gulf of Mexico, leading to negative impacts on the economy and the environment of those areas. Hence, it is now crucial to develop strategie
Externí odkaz:
https://doaj.org/article/9760ee8111e94075b7f98276258f5b05
Self-sensing polymeric materials based on fluorescent microcapsules for the detection of microcracks
Autor:
Sandra Roche, Gemma Ibarz, Cristina Crespo, Agustín Chiminelli, Andreia Araujo, Raquel Santos, Zhenxue Zhang, Xiaoying Li, Hanshan Dong
Publikováno v:
Journal of Materials Research and Technology, Vol 16, Iss , Pp 505-515 (2022)
In this study, self-sensing materials have been developed owing to their ability to indicate material damage through an evident optical signal. For this, fluorescent core–shell microcapsules were synthesized by in situ polymerization in an oil-wate
Externí odkaz:
https://doaj.org/article/69ff3bd8a26d49838417eb4e4899f687
Autor:
Sandra Roche, Patricia Gaule, Deirdre Winrow, Nupur Mukherjee, Fiona O'Neill, Neil T Conlon, Justine Meiller, Denis M Collins, Alexandra Canonici, Mohammed Ibrahim Fawsi, Alejandra Estepa-Fernández, Stephen F Madden, John Crown, Norma O'Donovan, Alex J Eustace
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282512 (2023)
Triple Negative Breast Cancer (TNBC), a subtype of breast cancer, has fewer successful therapeutic therapies than other types of breast cancer. Insulin-like growth factor receptor 1 (IGF1R) and the Insulin receptor (IR) are associated with poor outco
Externí odkaz:
https://doaj.org/article/b9644b158fb94f80a2b68dadca1eef19
Autor:
Fiona O’Neill, Taylor-Jade Allen-Coyle, Sandra Roche, Justine Meiller, Neil T. Conlon, Niall Swan, Robert M. Straubinger, Justin Geoghegan, Ninfa L. Straubinger, Kevin Conlon, Ray McDermott, Finbarr O’Sullivan, Michael Henry, Paula Meleady, Gerard McVey, Robert O’Connor, Michael Moriarty, Martin Clynes
Publikováno v:
Life, Vol 13, Iss 3, p 608 (2023)
Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors, adjacent normal tissue, and matched patient-derived xenograft models using microarray screening. RNA was extracted from seven tumor, five adjacent normal, and eigh
Externí odkaz:
https://doaj.org/article/a7c66f94d63d447e9e0fc09d6ba50f6e
Autor:
Alexandra Canonici, Alacoque L. Browne, Mohamed F. K. Ibrahim, Kevin P. Fanning, Sandra Roche, Neil T. Conlon, Fiona O’Neill, Justine Meiller, Mattia Cremona, Clare Morgan, Bryan T. Hennessy, Alex J. Eustace, Flavio Solca, Norma O’Donovan, John Crown
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Background: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited therapeutic options. Epidermal growth factor receptor (EGFR) has been shown to be over-expressed in TNBC and represents a rational treatment targe
Externí odkaz:
https://doaj.org/article/30ed8d6b4bc948429c56a9912d216c9d
Autor:
Sandra Roche, Fiona O’Neill, Jean Murphy, Niall Swan, Justine Meiller, Neil T. Conlon, Justin Geoghegan, Kevin Conlon, Ray McDermott, Rozana Rahman, Sinead Toomey, Ninfa L. Straubinger, Robert M. Straubinger, Robert O’Connor, Gerard McVey, Michael Moriarty, Martin Clynes
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 962 (2020)
Pancreatic cancer remains among the most lethal cancers worldwide, with poor early detection rates and poor survival rates. Patient-derived xenograft (PDX) models have increasingly been used in preclinical and clinical research of solid cancers to fu
Externí odkaz:
https://doaj.org/article/64b5b86bd766491a894877cb51122c31
Autor:
Tapesh Santra, Sandra Roche, Neil Conlon, Norma O'Donovan, John Crown, Robert O'Connor, Walter Kolch
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177058 (2017)
Molecularly targeted therapeutics hold promise of revolutionizing treatments of advanced malignancies. However, a large number of patients do not respond to these treatments. Here, we take a systems biology approach to understand the molecular mechan
Externí odkaz:
https://doaj.org/article/e1dff045538248eb9ca20ebb0272e39e
Autor:
Orla Coleman, Michael Henry, Fiona O'Neill, Sandra Roche, Niall Swan, Lorraine Boyle, Jean Murphy, Justine Meiller, Neil T. Conlon, Justin Geoghegan, Kevin C. Conlon, Vincent Lynch, Ninfa L. Straubinger, Robert M. Straubinger, Gerard McVey, Michael Moriarty, Paula Meleady, Martin Clynes
Publikováno v:
Proteomes, Vol 6, Iss 4, p 45 (2018)
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide; it develops in a relatively symptom-free manner, leading to rapid disease progression and metastasis, leading to a 5-year survival rate of less than 5%. A lack of depe
Externí odkaz:
https://doaj.org/article/f10951bc0cb2430db525772b88936f29
Autor:
Sundaravadivel Balasubramanian, Dorea L Pleasant, Harinath Kasiganesan, Lakeya Quinones, Yuhua Zhang, Kamala P Sundararaj, Sandra Roche, Robert O'Connor, Amy D Bradshaw, Dhandapani Kuppuswamy
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140273 (2015)
Reactive cardiac fibrosis resulting from chronic pressure overload (PO) compromises ventricular function and contributes to congestive heart failure. We explored whether nonreceptor tyrosine kinases (NTKs) play a key role in fibrosis by activating ca
Externí odkaz:
https://doaj.org/article/17263035ee9d48a39251b41bc6767773