Intrinsic host susceptibility among multiple species to intranasal SARS-CoV-2 identifies diverse virological, biodistribution and pathological outcomes

Autor: Neil Berry, Deborah Ferguson, Sarah Kempster, Jo Hall, Claire Ham, Adrian Jenkins, Vicky Rannow, Elaine Giles, Rose Leahy, Sara Goulding, Arturo Fernandez, Yemisi Adedeji, Sandrine Vessillier, Deepa Rajagopal, Sandra Prior, Yann Le Duff, Matthew Hurley, Sarah Gilbert, Martin Fritzsche, Ryan Mate, Nicola Rose, Robert J. Francis, Kirsty MacLellan-Gibson, Alejandro Suarez-Bonnet, Simon Priestnall, Neil Almond

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract SARS-CoV-2 exhibits a diverse host species range with variable outcomes, enabling differential host susceptibility studies to assess suitability for pre-clinical countermeasure and pathogenesis studies. Baseline virological, molecular and pa

Externí odkaz: https://doaj.org/article/0bdbc34a3c9f4aa9acf1c9f0c03b6ceb

2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A – Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC & Part 1B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine)

Autor: Surinder Kaur, Stephen C Alley, Matt Szapacs, Amanda Wilson, Eugene Ciccimaro, Dian Su, Neil Henderson, Linzhi Chen, Fabio Garofolo, Shawna Hengel, Wenying Jian, John F Kellie, Anita Lee, John Mehl, Joe Palandra, Haibo Qiu, Natasha Savoie, Diaa Shakleya, Ludovicus Staelens, Hiroshi Sugimoto, Giane Sumner, Jan Welink, Robert Wheller, Y-J Xue, Jianing Zeng, Jinhui Zhang, Huiyu Zhou, Jian Wang, Scott Summerfield, Olga Kavetska, Lieve Dillen, Ragu Ramanathan, Mike Baratta, Arindam Dasgupta, Anna Edmison, Luca Ferrari, Sally Fischer, Daniela Fraier, Sam Haidar, Kathrin Heermeier, Christopher James, Allena Ji, Lina Luo, Gustavo Mendes Lima Santos, Noah Post, Anton I Rosenbaum, Sune Sporring, Sekhar Surapaneni, Stephen Vinter, Katty Wan, Eric Woolf, Seongeun (Julia) Cho, Elham Kossary, Sandra Prior, Mohsen Rajabi Abhari, Catherine Soo, Yow-Ming Wang, Abbas Bandukwala, Elana Cherry, Isabelle Cludts, Soma Ghosh, Shirley Hopper, Akiko Ishii-Watabe, Susan Kirshner, Kevin Maher, Kimberly Maxfield, Joao Pedras-Vasconcelos, Yoshiro Saito, Dean Smith, Therese Solstad, Daniela Verthelyi, Meenu Wadhwa, Leslie Wagner, Günter Waxenecker, Haoheng Yan, Lucia Zhang

Publikováno v: Bioanalysis. 14:505-580

The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held on 27 September to 1 October 2021. Even with a last-minute move from in-person to virtual, an overwhelmingly high number of nearly 900 professionals representing ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50312b92e46093984de8cada020a3696
https://doi.org/10.4155/bio-2022-0078

2021 White Paper on Recent Issues in Bioanalysis: ISR for Biomarkers, Liquid Biopsies, Spectral Cytometry, Inhalation/OralMultispecific Biotherapeutics, Accuracy/LLOQ for Flow Cytometry (

Autor: Sarah, Hersey, Steve, Keller, Joel, Mathews, Lindsay, King, Abbas, Bandukwala, Flora, Berisha, Mary, Birchler, Joe, Bower, Valerie, Clausen, Jose, Duarte, Fabio, Garofolo, Shirley, Hopper, Sumit, Kar, Omar, Mabrouk, Jean-Claude, Marshall, Kristina, McGuire, Michael, Naughton, Yoshiro, Saito, Imelda, Schuhmann, Gizette, Sperinde, Priscila, Teixeira, Alessandra, Vitaliti, Yow-Ming, Wang, Richard, Wnek, Yan, Zhang, Sue, Spitz, Vilma, Decman, Steven, Eck, Jose, Estevam, Polina, Goihberg, Enrique Gómez, Alcaide, Christèle, Gonneau, Michael Nathan, Hedrick, Gregory, Hopkins, Fabian, Junker, Sandra, Nuti, Ulrike, Sommer, Nathan, Standifer, Chad, Stevens, Erin, Stevens, Carrie, Hendricks, Meenu, Wadhwa, Albert, Torri, Mark, Ma, Shannon, Harris, Seema, Kumar, Michael A, Partridge, Teresa, Caiazzo, Shannon, Chilewski, Isabelle, Cludts, Kelly, Coble, Boris, Gorovits, Christine, Grimaldi, Gregor, Jordan, John, Kamerud, Beth, Leary, Meina, Liang, Hanjo, Lim, Andrew, Mayer, Ellen, O'Connor, Nisha, Palackal, Johann, Poetzl, Sandra, Prior, Mohsen Rajabi, Abhari, Natasha, Savoie, Catherine, Soo, Mark, Ware, Bonnie, Wu, Yang, Xu, Tong-Yuan, Yang, Jad, Zoghbi

Publikováno v: Bioanalysis. 14(10)

The 15th edition of the Workshop on Recent Issues in Bioanalysis (15th WRIB) was held on 27 September to 1 October 2021. Even with a last-minute move from in-person to virtual, an overwhelmingly high number of nearly 900 professionals representing ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::03ba644e56e696de5df5c0b71a7127e6
https://pubmed.ncbi.nlm.nih.gov/35578974

Maintaining 'standards' for biosimilar monoclonal antibodies

Autor: Sandra, Prior, Clive, Metcalfe, Simon E, Hufton, Meenu, Wadhwa, Christian K, Schneider, Chris, Burns

Publikováno v: Nature biotechnology. 39(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3c39aba3c388dc4b81bebdfb1d98353
https://pubmed.ncbi.nlm.nih.gov/33664522

Approaches to Mitigate the Unwanted Immunogenicity of Therapeutic Proteins during Drug Development

Autor: Jennifer N. Schneider, Dharmesh D. Desai, Sandra Prior, Tarik A. Khan, Alexandra Joseph, Laura I. Salazar-Fontana, Renuka Pillutla, Radha Ramakrishnan

Publikováno v: The AAPS journal. 19(2)

All biotherapeutics have the potential to induce an immune response. This immunological response is complex and, in addition to antibody formation, involves T cell activation and innate immune responses that could contribute to adverse effects. Integ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45ed979385dcf73d7e24b4ef9edecbd
https://pubmed.ncbi.nlm.nih.gov/28083796