2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia

Autor: Susan F. Fitzpatrick, Simon Lambden, David Macias, Zudin Puthucheary, Sandra Pietsch, Lee Mendil, Mark J. W. McPhail, Randall S. Johnson

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration in vivo, and i

Externí odkaz: https://doaj.org/article/00435b3729d84c3e808bfa4ffbe064d9

Comparison of peripheral and central schizophrenia biomarker profiles.

Autor: Laura W Harris, Sandra Pietsch, Tammy M K Cheng, Emanuel Schwarz, Paul C Guest, Sabine Bahn

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e46368 (2012)

We have recently shown that a molecular biomarker signature comprised of inflammatory, hormonal and growth factors occurs in the blood serum from first onset schizophrenia patients. Here, we use the same platform to investigate post mortem brain tiss

Externí odkaz: https://doaj.org/article/71868fd040e741eaa72d14fdcedca0ac

Data from Infiltration of Tumors Is Regulated by T cell–Intrinsic Nitric Oxide Synthesis

Autor: Randall S. Johnson, Pedro Veliça, Cristina M. Branco, Iosifina Foskolou, Sandra Pietsch, Emilia Marklund, Milos Gojkovic, Carolin Brombach, Laura Barbieri, Lena C.M. Krause, Eleanor Minogue, David Bargiela, Pedro P. Cunha

Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell–derived NO has been shown to suppress T-cell responses,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d0e287a4e9d71e4291efb0729bef0a
https://doi.org/10.1158/2326-6066.c.6551094

Infiltration of Tumors Is Regulated by T cell-Intrinsic Nitric Oxide Synthesis

Autor: Pedro P. Cunha, David Bargiela, Eleanor Minogue, Lena C.M. Krause, Laura Barbieri, Carolin Brombach, Milos Gojkovic, Emilia Marklund, Sandra Pietsch, Iosifina Foskolou, Cristina M. Branco, Pedro Veliça, Randall S. Johnson

Publikováno v: Cunha, P P, Bargiela, D, Minogue, E, Krause, L C M, Barbieri, L, Brombach, C, Gojkovic, M, Marklund, E, Pietsch, S, Foskolou, I, Branco, C M, Veliça, P & Johnson, R S 2023, ' Infiltration of tumors is regulated by T cell-intrinsic nitric oxide synthesis ', Cancer Immunology Research, vol. 11, no. 3, pp. 351-363 . https://doi.org/10.1158/2326-6066.CIR-22-0387

Nitric oxide (NO) is a signaling molecule produced by NO synthases (NOS1–3) to control processes such as neurotransmission, vascular permeability, and immune function. Although myeloid cell–derived NO has been shown to suppress T-cell responses,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740abd999c45f3e1eb6d04286fb0212e
https://www.repository.cam.ac.uk/handle/1810/347533

Metabolite X is a novel biomarker for sepsis diagnosis and treatment

Autor: Sandra Pietsch, David Macías, Simon Lambden, Mark McPhil, Zudin Puthucheary, Randall S. Johnson, Lee Mendil, Susan Fitzpatrick

Publikováno v: Access Microbiology. 2

Background: Sepsis develops when the initial, appropriate host response to an infection becomes amplified and subsequently dysregulated. Recent research has shown that the pathogenesis of sepsis can only partially be explained by an aberrant inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78bab23d1716cc815dec38a48db71fbe
https://doi.org/10.1099/acmi.fis2019.po0094