Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Sandra P. D'Angelo"'
Autor:
Alexandra Gyurdieva, Stefan Zajic, Ya-Fang Chang, E. Andres Houseman, Shan Zhong, Jaegil Kim, Michael Nathenson, Thomas Faitg, Mary Woessner, David C. Turner, Aisha N. Hasan, John Glod, Rosandra N. Kaplan, Sandra P. D’Angelo, Dejka M. Araujo, Warren A. Chow, Mihaela Druta, George D. Demetri, Brian A. Van Tine, Stephan A. Grupp, Gregg D. Fine, Ioanna Eleftheriadou
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Biomarkers predictive of response to T cell therapy remain to be better defined. This study identifies potential predictive and pharmacodynamic markers of response to NY-ESO-1 T-cell therapy in a solid tumor that may inform lymphodepletion, cell dose
Externí odkaz:
https://doaj.org/article/96c810f6a32a4df78125147d2a952087
Autor:
Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh A. Smith, Cristina R. Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas D. Socci, Satshil Rana, Rodrigo Gularte-Mérida, Ahmet Zehir, Mrinal M. Gounder, Timothy G. Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan A. Strong, Jake Stoller, Jason E. Chan, Ping Chi, Sandra P. D’Angelo, Mark A. Dickson, Ciara M. Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul A. Meyers, Leonard H. Wexler, Emily K. Slotkin, Julia L. Glade Bender, Neerav N. Shukla, Martee L. Hensley, John H. Healey, Michael P. La Quaglia, Kaled M. Alektiar, Aimee M. Crago, Sam S. Yoon, Brian R. Untch, Sarah Chiang, Narasimhan P. Agaram, Meera R. Hameed, Michael F. Berger, David B. Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer, William D. Tap
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequenc
Externí odkaz:
https://doaj.org/article/89c42dddd0f647ee90d7805699d564f6
Autor:
Sandra P. D’Angelo, Allison L. Richards, Anthony P. Conley, Hyung Jun Woo, Mark A. Dickson, Mrinal Gounder, Ciara Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Evan Rosenbaum, Ping Chi, Benjamin Nacev, Jason E. Chan, Emily K. Slotkin, Hannah Kiesler, Travis Adamson, Lilan Ling, Pavitra Rao, Shreyaskumar Patel, Jonathan A. Livingston, Samuel Singer, Narasimhan P. Agaram, Cristina R. Antonescu, Andrew Koff, Joseph P. Erinjeri, Sinchun Hwang, Li-Xuan Qin, Mark T. A. Donoghue, William D. Tap
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The activity of PD-1 blockade in patients with sarcoma has been modest so far. Here, the authors report the results of a pilot clinical trial to assess the efficacy and safety of bempegaldesleukin, a CD122-preferential interleukin-2 (IL-2) pathway ag
Externí odkaz:
https://doaj.org/article/b6788f9bd032450d95559d4440fb175b
Autor:
Gyuhee Seong, Sandra P. D’Angelo
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Soft tissue sarcoma is a rare and aggressive disease with a 40 to 50% metastasis rate. The limited efficacy of traditional approaches with surgery, radiation, and chemotherapy has prompted research in novel immunotherapy for soft tissue sarcoma. Immu
Externí odkaz:
https://doaj.org/article/e9b4b74e8bda4a7799b36198a82129a5
Autor:
Edmund K. Bartlett, Sandra P. D’Angelo, Ciara M. Kelly, Robert H. Siegelbaum, Charles Fisher, Cristina R. Antonescu, Charlotte E. Ariyan
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Treatment options for patients with advanced sarcoma remain limited. Promising responses to checkpoint inhibition have been observed, but responses to single-agent PD-1 inhibition are rare. We report on two patients with multiply recurrent myxofibros
Externí odkaz:
https://doaj.org/article/0fde626e0a344e988f6d4acd8eddfa68
Autor:
Indu Ramachandran, Daniel E. Lowther, Rebecca Dryer-Minnerly, Ruoxi Wang, Svetlana Fayngerts, Daniel Nunez, Gareth Betts, Natalie Bath, Alex J. Tipping, Luca Melchiori, Jean-Marc Navenot, John Glod, Crystal L. Mackall, Sandra P. D’Angelo, Dejka M. Araujo, Warren A. Chow, George D. Demetri, Mihaela Druta, Brian A. Van Tine, Stephan A. Grupp, Albiruni R. Abdul Razak, Breelyn Wilky, Malini Iyengar, Trupti Trivedi, Erin Van Winkle, Karen Chagin, Rafael Amado, Gwendolyn K. Binder, Samik Basu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Background Gene-modified autologous T cells expressing NY-ESO-1c259, an affinity-enhanced T-cell receptor (TCR) reactive against the NY-ESO-1-specific HLA-A*02-restricted peptide SLLMWITQC (NY-ESO-1 SPEAR T-cells; GSK 794), have demonstrated
Externí odkaz:
https://doaj.org/article/08dda14b5f1b4ef08600740b083a4b11
Autor:
Charles Sutton, Yachao Zhang, DaeHee Kim, Hooman Yarmohammadi, Etay Ziv, Franz E. Boas, Constantinos T. Sofocleous, William D. Tap, Sandra P. D’Angelo, Joseph P. Erinjeri
Publikováno v:
Sarcoma, Vol 2020 (2020)
One way to enhance quality of life for patients with metastatic sarcoma is to maximize time off chemotherapy—a chemotherapy-free interval. While image-guided ablation of sarcoma metastases may reduce the need for chemotherapy, it remains unknown ho
Externí odkaz:
https://doaj.org/article/aec07cb24eaa413a84098c5211bebf4d
Autor:
Howard L. Kaufman, Jeffery S. Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P. D’Angelo, Kent C. Shih, Céleste Lebbé, Michele Milella, Isaac Brownell, Karl D. Lewis, Jochen H. Lorch, Anja von Heydebreck, Meliessa Hennessy, Paul Nghiem
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-7 (2018)
Abstract Background Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer associated with poor survival outcomes in patients with distant metastatic disease (mMCC). In an initial analysis from JAVELIN Merkel 200, a phase 2, prospective, open-
Externí odkaz:
https://doaj.org/article/8702b9ace3ed4ea195be94aaa6b2d065
Autor:
Christopher A. Barker, Samuel K. Kim, Sadna Budhu, Konstantina Matsoukas, Anthony F. Daniyan, Sandra P. D’Angelo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-7 (2018)
Abstract Background Cytokine release syndrome (CRS) has been reported after immunologic manipulations, most often through therapeutic monoclonal antibodies. To our knowledge, CRS after radiation therapy (RT) for cancer has not been reported before. T
Externí odkaz:
https://doaj.org/article/7604780bf8d74b849a5372e8dd2b3ff9
Autor:
David J. Chung, Richard D. Carvajal, Michael A. Postow, Sneh Sharma, Katherine B. Pronschinske, Justin A. Shyer, Shahnaz Singh-Kandah, Mark A. Dickson, Sandra P. D'Angelo, Jedd D. Wolchok, James W. Young
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Purpose: We conducted a phase I vaccine trial to determine safety, toxicity, and immunogenicity of autologous Langerhans-type dendritic cells (LCs), electroporated with murine tyrosinase-related peptide-2 (mTRP2) mRNA in patients with resected AJCC s
Externí odkaz:
https://doaj.org/article/3f8a70d8c6f34f29b3bbab139b4f793b