Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sandra Ortega Ugalde"'
Autor:
Joel Doré, Sandra Ortega Ugalde
Publikováno v:
Frontiers in Astronomy and Space Sciences, Vol 10 (2023)
Humans are microbial, ecosystems and symbioses. The relationship that humans have with their microbiomes is an essential element to maintaining health and wellbeing. Recent changes in lifestyles may have fostered an alteration of this symbiosis, whic
Externí odkaz:
https://doaj.org/article/484bc87f025444fbaa80fdb3906f6554
Autor:
Alexander Speer, Kerstin Wallraven, Sandra Ortega Ugalde, Tom N. Grossmann, Jan N. M. Commandeur, Wilbert Bitter
Publikováno v:
Ortega Ugalde, S, Wallraven, K, Speer, A, Bitter, W, Grossmann, T N & Commandeur, J N M 2020, ' Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis ', Biochemical Pharmacology, vol. 177, 113938, pp. 113938 . https://doi.org/10.1016/j.bcp.2020.113938
Biochemical Pharmacology, 177:113938, 1-14. Elsevier Inc.
Biochemical Pharmacology, 177:113938. Elsevier Inc.
Ortega Ugalde, S, Wallraven, K, Speer, A, Bitter, W, Grossmann, T N & Commandeur, J N M 2020, ' Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis ', Biochemical Pharmacology, vol. 177, 113938, pp. 1-14 . https://doi.org/10.1016/j.bcp.2020.113938
Biochemical Pharmacology, 177:113938, 1-14. Elsevier Inc.
Biochemical Pharmacology, 177:113938. Elsevier Inc.
Ortega Ugalde, S, Wallraven, K, Speer, A, Bitter, W, Grossmann, T N & Commandeur, J N M 2020, ' Acetylene containing cyclo(L-Tyr-L-Tyr)-analogs as mechanism-based inhibitors of CYP121A1 from Mycobacterium tuberculosis ', Biochemical Pharmacology, vol. 177, 113938, pp. 1-14 . https://doi.org/10.1016/j.bcp.2020.113938
Tuberculosis (TB) is a globally significant infective disease that is caused by a single infectious agent, Mycobacterium tuberculosis (Mtb). Because of the rise in the number of multidrug-resistant (MDR) TB strains, identification of alternative drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b4d2df84378e08e1bf262981ea247f
https://doi.org/10.1016/j.bcp.2020.113938
https://doi.org/10.1016/j.bcp.2020.113938
Publikováno v:
Ortega Ugalde, S, Ma, D, Cali, J J & Commandeur, J N M 2019, ' Evaluation of Luminogenic Substrates as Probe Substrates for Bacterial Cytochrome P450 Enzymes : Application to Mycobacterium tuberculosis ', SLAS Discovery, vol. 24, no. 7, pp. 745-754 . https://doi.org/10.1177/2472555219853220, https://doi.org/10.1177/2472555219853220
SLAS Discovery, 24(7), 745-754. SAGE Publications Inc.
SLAS Discovery, 24(7), 745-754. SAGE Publications Inc.
Several cytochrome P450 enzymes (CYPs) encoded in the genome of Mycobacterium tuberculosis (Mtb) are considered potential new drug targets due to the essential roles they play in bacterial viability and in the establishment of chronic intracellular i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf556f7bf7757d680376e5748411c86
https://doi.org/10.1177/2472555219853220
https://doi.org/10.1177/2472555219853220
Autor:
Nico P. E. Vermeulen, Daan P. Geerke, Sandra Ortega Ugalde, Jan N. M. Commandeur, Wilbert Bitter, Rosa A. Luirink
Publikováno v:
Ortega Ugalde, S, Luirink, R A, Geerke, D P, Vermeulen, N P E, Bitter, W & Commandeur, J N M 2017, ' Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium ', Journal of Inorganic Biochemistry, vol. 180, 180, pp. 48 . https://doi.org/10.1016/j.jinorgbio.2017.12.003
Journal of Inorganic Biochemistry, 180:180. Elsevier Inc.
Journal of Inorganic Biochemistry, 180:180. Elsevier Inc.
CYP130 belongs to the subset of cytochrome P450s from Mycobacterium tuberculosis (Mtb) that have been structurally characterized. Despite several efforts for its functional characterization, CYP130 is still considered an orphan enzyme for which no en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa072c3ebd8a64a61a16b5eafa8016c2
https://doi.org/10.1016/j.jinorgbio.2017.12.003
https://doi.org/10.1016/j.jinorgbio.2017.12.003
Publikováno v:
Slas Discovery
Several cytochrome P450 enzymes (CYPs) encoded in the genome of Mycobacterium tuberculosis (Mtb) are considered potential new drug targets due to the essential roles they play in bacterial viability and in the establishment of chronic intracellular i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e293b678be8d8dbecbaa8a683cbae0fe
https://pubmed.ncbi.nlm.nih.gov/31208248
https://pubmed.ncbi.nlm.nih.gov/31208248
Autor:
Maikel Boot, Jan N. M. Commandeur, J. Chris Vos, Sandra Ortega Ugalde, Paul Jennings, Wilbert Bitter
Publikováno v:
Ortega Ugalde, S, Boot, M, Commandeur, J N M, Jennings, P, Bitter, W & Vos, J C 2019, ' Function, essentiality, and expression of cytochrome P450 enzymes and their cognate redox partners in Mycobacterium tuberculosis: are they drug targets? ', Applied Microbiology and Biotechnology, vol. 103, no. 9, pp. 3597-3614 . https://doi.org/10.1007/s00253-019-09697-z
Applied Microbiology and Biotechnology, 103(9), 3597-3614. Springer Verlag
Applied Microbiology and Biotechnology, 103(9), 3597-3614. Springer Verlag
This review covers the current knowledge of the cytochrome P450 enzymes (CYPs) of the human pathogen Mycobacterium tuberculosis (Mtb) and their endogenous redox partners, focusing on their biological function, expression, regulation, involvement in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e2d2ef4f32e4ef20a57cdcc4b44436
https://research.vumc.nl/en/publications/9e189f5d-4ee2-4ee3-9ec7-a35e721b56ba
https://research.vumc.nl/en/publications/9e189f5d-4ee2-4ee3-9ec7-a35e721b56ba
