Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sandra Olthof"'
Autor:
Albertina Ausema, Martha Ritsema, Gerald de Haan, Leonid Bystrykh, Ronald van Os, Sandra Olthof, Gerwin Huls, Vincent van den Boom, Marta A. Walasek
Publikováno v:
Blood
Blood, 119(13), 3050-3059. AMER SOC HEMATOLOGY
Blood; Vol 119
Blood, 119, 13, pp. 3050-9
Blood, 119, 3050-9
Blood, 119(13), 3050-3059. AMER SOC HEMATOLOGY
Blood; Vol 119
Blood, 119, 13, pp. 3050-9
Blood, 119, 3050-9
Despite increasing knowledge on the regulation of hematopoietic stem/progenitor cell (HSPC) self-renewal and differentiation, in vitro control of stem cell fate decisions has been difficult. The ability to inhibit HSPC commitment in culture may be of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2110809ca5565f0eb445bbdab7ef1b2
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, 208(13), 2691-2703. ROCKEFELLER UNIV PRESS
Journal of Experimental Medicine, 208(13), 2691-2703. ROCKEFELLER UNIV PRESS
As shown using clonal assays, the mouse HSC population undergoes quantitative as well as qualitative changes with age, including lineage differentiation, HSC pool size, marrow-homing efficiency, and self-renewal.
Hematopoietic stem cell (HSC) po
Hematopoietic stem cell (HSC) po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eb829aff3d3044db1f056ba9f2419b
https://doi.org/10.1084/jem.20111490
https://doi.org/10.1084/jem.20111490
Autor:
Jan Jacob Schuringa, Edo Vellenga, Ali Agool, Carolien M. Woolthuis, Sandra Olthof, Riemer H. J. A. Slart, G. Huls, W. M. Smid
Publikováno v:
Bone marrow transplantation, 46(1), 110-115. Nature Publishing Group
Autologous SCT (auto-SCT) introduces a reduced tolerance to chemotherapy even in patients with adequate engraftment, suggesting long-term effects of the transplantation procedure on the BM capacity. To study the hematopoietic cell compartment after a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8381f7a19e5cd053d7963f812f9d5e
https://hdl.handle.net/11370/5332e88c-696d-44fc-8491-df4161c19476
https://hdl.handle.net/11370/5332e88c-696d-44fc-8491-df4161c19476
Autor:
Sarah J. Horton, Aleksandra Rizo, Gerald de Haan, Bert Dontje, Ronald van Os, Edo Vellenga, Albertina Ausema, Sandra Olthof, Vincent van den Boom, Jan Jacob Schuringa
Publikováno v:
Blood, 116(22), 4621-4630. AMER SOC HEMATOLOGY
The major limitation for the development of curative cancer therapies has been an incomplete understanding of the molecular mechanisms driving cancer progression. Human models to study the development and progression of chronic myeloid leukemia (CML)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7088617c19e4b47f468ec8efec55d767
https://doi.org/10.1182/blood-2010-02-270660
https://doi.org/10.1182/blood-2010-02-270660
Publikováno v:
European Journal of Haematology, 83(3), 235-245. Wiley
Objective:During megakaryopoiesis, hematopoietic progenitor cells in the bone marrow proliferate and ultimately differentiate in mature megakaryocytes (MK). We and others have recently described a role for the mammalian target of Rapamycin (mTOR) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ccfac970830f3c89afaf18ac44d0f8
https://doi.org/10.1111/j.1600-0609.2009.01263.x
https://doi.org/10.1111/j.1600-0609.2009.01263.x
Autor:
Gerald de Haan, Sandra Olthof, A. Lyndsay Drayer, Ido P. Kema, Vincent W. Bloks, Pieter J. J. Sauer, Nel R. Blom, Folkert Kuipers, Janine K. Kruit, Edo Vellenga
Publikováno v:
The Journal of Biological Chemistry, 283(10), 6281-6287. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Mutations in either ABCG5 or ABCG8 cause sitosterolemia, an inborn error of metabolism characterized by high plasma plant sterol concentrations. Recently, macrothrombocytopenia was described in a number of sitosterolemia patients, linking hematologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc76d544f8a30d3007e1eaffbf6bed7
https://doi.org/10.1074/jbc.m706689200
https://doi.org/10.1074/jbc.m706689200
Autor:
Jan Jacob Schuringa, Gwenny M. Fuhler, Edo Vellenga, Sandra Olthof, Paul J. Coffer, A. Lyndsay Drayer
Publikováno v:
Blood, 111(1), 359-368. AMER SOC HEMATOLOGY
Patients with myelodysplasia (MDS) show a differentiation defect in the multipotent stem-cell compartment. An important factor in stem-cell differentiation is their proper localization within the bone marrow microenvironment, which is regulated by st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82e1f2ae84f402850460f0719827f2a
https://doi.org/10.1182/blood-2006-11-060632
https://doi.org/10.1182/blood-2006-11-060632
Publikováno v:
STEM CELLS, 24(1), 105-114. Wiley-Blackwell
Thrombopoietin (TPO) is a potent regulator of megakaryopoiesis and stimulates megakaryocyte (MK) progenitor expansion and MK differentiation. In this study, we show that TPO induces activation of the mammalian target of rapamycin (mTOR) signaling pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f291aca41bb745ed0312f9ac296206
https://doi.org/10.1634/stemcells.2005-0062
https://doi.org/10.1634/stemcells.2005-0062
Autor:
Sandra Olthof, Alice Gerrits, Leonid Bystrykh, Martha Ritsema, Gerald de Haan, Ellen Weersing, Marta A. Walasek, Erik Zwart, Ronald van Os
Publikováno v:
Blood, 119(2), 377-387. AMER SOC HEMATOLOGY
Hematopoietic stem/progenitor cell (HSPC) traits differ between genetically distinct mouse strains. For example, DBA/2 mice have a higher HSPC frequency compared with C57BL/6 mice. We performed a genetic screen for micro-RNAs that are differentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42a239ebe2e58ec2fc363f688519e61
https://pubmed.ncbi.nlm.nih.gov/22123844
https://pubmed.ncbi.nlm.nih.gov/22123844
Publikováno v:
Blood, 114(8), 1498-1505. AMER SOC HEMATOLOGY
High expression of BMI1 in acute myeloid leukemia (AML) cells is associated with an unfavorable prognosis. Therefore, the effects of down-modulation of BMI1 in normal and leukemic CD34+ AML cells were studied using a lentiviral RNA interference appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8656012db4dbcd013d62ead485a48be
https://research.rug.nl/en/publications/0bdc6730-75b6-409d-aeab-ed0423bebe50
https://research.rug.nl/en/publications/0bdc6730-75b6-409d-aeab-ed0423bebe50
