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Autor:
Maria M. O’Sullivan, Eric M. Cordi, Jon Blunt, Gregory W. Sluggett, Ciaran Byrne, John A. Ragan, Brian G. Conway, Corey L. Stanchina, Sandra Mullane, Esmort Chisowa, Stuart Taylor, Janice E. Sieser, Denis Lynch, Leo Joseph Letendre, Marcella Whelan, Holly Strohmeyer, Robert A. Singer, Paul Bowles, Kyle R. Leeman
Publikováno v:
Organic Process Research & Development. 18:26-35
This is the first in a series of three papers describing the identification and development of a commercial synthesis of filibuvir (1). This contribution describes development of an Evans aldol reaction to control the tertiary alcohol stereocenter, a