Metformin Ameliorates Dysfunctional Traits of Glibenclamide- and Glucose-Induced Insulin Secretion by Suppression of Imposed Overactivity of the Islet Nitric Oxide Synthase-NO System.

Autor: Ingmar Lundquist, Israa Mohammed Al-Amily, Sandra Meidute Abaraviciene, Albert Salehi

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165668 (2016)

Metformin lowers diabetic blood glucose primarily by reducing hepatic gluconeogenesis and increasing peripheral glucose uptake. However, possible effects by metformin on beta-cell function are incompletely understood. We speculated that metformin mig

Externí odkaz: https://doaj.org/article/1cf2ed1499484ae7b6ff84813beb8665

Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.

Autor: Albert Salehi, Sandra Meidute Abaraviciene, Javier Jimenez-Feltstrom, Claes-Göran Ostenson, Suad Efendic, Ingmar Lundquist

Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2165 (2008)

BACKGROUND:A distinctive feature of type 2 diabetes is inability of insulin-secreting beta-cells to properly respond to elevated glucose eventually leading to beta-cell failure. We have hypothesized that an abnormally increased NO production in the p

Externí odkaz: https://doaj.org/article/7965af37df864792a126895489a4f4d6

Correction: Excessive Islet NO Generation in Type 2 Diabetic GK Rats Coincides with Abnormal Hormone Secretion and Is Counteracted by GLP-1.

Autor: Albert Salehi, Sandra Meidute Abaraviciene, Javier Jimenez-Feltstrom, Claes-Göran Östenson, Suad Efendic, Ingmar Lundquist

Publikováno v: PLoS ONE, Vol 3, Iss 6 (2008)

Externí odkaz: https://doaj.org/article/603b701743b440aca56989767c397ab4

Abnormally decreased NO and augmented CO production in islets of the leptin-deficient ob/ob mouse might contribute to explain hyperinsulinemia and islet survival in leptin-resistant type 2 obese diabetes

Autor: Javier Jimenez-Feltstrom, Albert Salehi, Ragnar Henningsson, Ingmar Lundquist, Sandra Meidute Abaraviciene

Publikováno v: Regulatory Peptides. 170:43-51

The role of the gaseous messengers NO and CO for β-cell function and survival is controversial. We examined this issue in the hyperglycemic-hyperinsulinemic ob/ob mouse, an animal model of type 2 obese diabetes, by studying islets from obese vs lean

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb0023a74831674e65d1e526d0d109a
https://doi.org/10.1016/j.regpep.2011.04.011

Metformin Ameliorates Dysfunctional Traits of Glibenclamide- and Glucose-Induced Insulin Secretion by Suppression of Imposed Overactivity of the Islet Nitric Oxide Synthase-NO System

Autor: Sandra Meidute Abaraviciene, Ingmar Lundquist, Israa Mohammed Al-Amily, Albert Salehi

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0165668 (2016)
PLoS One, San Francisco, Ca : Public Library of Science, 2016, Vol. 11, Iss. 11, Art. No. e0165668
PLoS ONE

Metformin lowers diabetic blood glucose primarily by reducing hepatic gluconeogenesis and increasing peripheral glucose uptake. However, possible effects by metformin on beta-cell function are incompletely understood. We speculated that metformin mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cba1a7731ef0470aea492bd11fcf407
https://doi.org/10.1371/journal.pone.0165668