Force tuning through regulation of clathrin-dependent integrin endocytosis

Autor: Alexander Kyumurkov, Anne-Pascale Bouin, Mathieu Boissan, Sandra Manet, Francesco Baschieri, Mathilde Proponnet-Guerault, Martial Balland, Olivier Destaing, Myriam Régent-Kloeckner, Claire Calmel, Alice Nicolas, François Waharte, Philippe Chavrier, Guillaume Montagnac, Emmanuelle Planus, Corinne Albiges-Rizo

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, 2023, 222 (1), ⟨10.1083/jcb.202004025⟩
Journal of Cell Biology, Rockefeller University Press, 2023, 222 (1), ⟨10.1083/jcb.202004025⟩

International audience; Integrin endocytosis is essential for many fundamental cellular processes. Whether and how the internalization impacts cellular mechanics remains elusive. Whereas previous studies reported the contribution of the integrin acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe61a3b2c47dad1962707fc3ffa2406
https://hal.science/hal-03834328/file/jcb_202004025.pdf

CCM2 deficient endothelial cells undergo a ROCK dependent reprogramming into senescence associated secretory phenotype

Autor: Apeksha Shapeti, Florent Chuffart, Paul Rivier, Sandra Manet, Corinne Albiges-Rizo, Emmanuelle Planus, Daphne Raphaelle Vannier, Hans Van Oosterwyck, Olivier Destaing, Eva Faurobert

Publikováno v: Angiogenesis
Angiogenesis, Springer Verlag, 2021, ⟨10.1007/s10456-021-09809-2⟩
Angiogenesis, 2021, ⟨10.1007/s10456-021-09809-2⟩

Cerebral cavernous malformation (CCM) is a cerebrovascular disease in which stacks of dilated haemorrhagic capillaries form focally in the brain. Whether and how defective mechanotransduction, cellular mosaicism and inflammation interplay to sustain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dc1de6d22d24c6e85e122c9d3886e8
https://hal.archives-ouvertes.fr/hal-03437734/document

Immunofluorescence of Cell-Cell and Cell-Extracellular Matrix Adhesive Defects in In Vitro Endothelial CCM Model: Juxtacrine Role of Mutant Extracellular Matrix on Wild-Type Endothelial Cells

Autor: Sandra, Manet, Daphné, Vannier, Anne-Pascale, Bouin, Justyna, Lisowska, Corinne, Albiges-Rizo, Eva, Faurobert

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2152

Endothelial cells lining cerebral cavernous malformations (CCM) present strong adhesive and mechanical defects. Increased cell contractility is a driver to the onset and the expansion of the CCM lesions. 2D in vitro endothelial models have been devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24824fb62055dd6a0308ea7e89ed2917
https://pubmed.ncbi.nlm.nih.gov/32524568

The CCM1-CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity

Autor: Justyna, Lisowska, Claudia Jasmin, Rödel, Sandra, Manet, Yekaterina A, Miroshnikova, Cyril, Boyault, Emmanuelle, Planus, Richard, De Mets, Hsiao-Hui, Lee, Olivier, Destaing, Hichem, Mertani, Gwénola, Boulday, Elisabeth, Tournier-Lasserve, Martial, Balland, Salim, Abdelilah-Seyfried, Corinne, Albiges-Rizo, Eva, Faurobert

Publikováno v: Journal of cell science. 131(15)

Endothelial integrity relies on a mechanical crosstalk between intercellular and cell-matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ab4557b1aba02166597036183190d51
https://pubmed.ncbi.nlm.nih.gov/30030370

VEGF165b, a splice variant of VEGF-A, promotes lung tumor progression and escape from anti-angiogenic therapies through a β1 integrin/VEGFR autocrine loop

Autor: Asma Boudria, Christian Brambilla, Nicolas Lemaître, Cherine Abou Faycal, Elisabeth Brambilla, Beatrice Eymin, Sylvie Gazzeri, Corinne Albiges-Rizo, Sandra Manet, Tao Jia, Chloé Didier, Denis Moro-Sibilot, Anne-Claire Toffart, Eva Faurobert, Michelle Keramidas, Jean-Luc Coll, Véronique Josserand, Stephanie Gout

Publikováno v: Oncogene
Oncogene, 2018, ⟨10.1038/s41388-018-0486-7⟩
Oncogene, Nature Publishing Group, 2018, 38 (7), pp.1050-1066. ⟨10.1038/s41388-018-0486-7⟩
Oncogene, 2018, 38 (7), pp.1050-1066. ⟨10.1038/s41388-018-0486-7⟩
Oncogene, Nature Publishing Group, 2018, ⟨10.1038/s41388-018-0486-7⟩

International audience; Vascular endothelial growth factor-A (VEGF-A) is highly subjected to alternative pre-mRNA splicing that generates several splice variants. The VEGFxxx and VEGFxxxb families encode splice variants of VEGF-A that differ only at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a53801fd1f8eb7affe6955792a3b296
https://doi.org/10.1038/s41388-018-0486-7