Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Sandra Macedo"'
Autor:
Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyr
Externí odkaz:
https://doaj.org/article/69835b309c8c4fcc8550fc5ffc4c0d4f
Autor:
Francisco Figueiredo, Zsuzsa Sárkány, Alexandra Silva, Daniela Vilasboas-Campos, Patrícia Maciel, Andreia Teixeira-Castro, Pedro M. Martins, Sandra Macedo-Ribeiro
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115258- (2023)
The accumulation of mutant ataxin-3 (Atx3) in neuronal nuclear inclusions is a pathological hallmark of Machado-Joseph disease (MJD), also known as Spinocerebellar Ataxia Type 3. Decreasing the protein aggregation burden is a possible disease-modifyi
Externí odkaz:
https://doaj.org/article/977bf6815f774f57bb5f7a7c83b979c3
Autor:
José A. Manso, Arturo Carabias, Zsuzsa Sárkány, José M. de Pereda, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT An important feature associated with Candida albicans pathogenicity is its ability to switch between yeast and hyphal forms, a process in which CaRas1 plays a key role. CaRas1 is activated by the guanine nucleotide exchange factor (GEF) CaCd
Externí odkaz:
https://doaj.org/article/91a4ad11f5194a0d9e9376efb1dace40
Autor:
Zsuzsa Sárkány, Fernando Rocha, Anna Bratek‐Skicki, Peter Tompa, Sandra Macedo‐Ribeiro, Pedro M. Martins
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract Liquid‐solid and liquid‐liquid phase separation (PS) drives the formation of functional and disease‐associated biological assemblies. Principles of phase equilibrium are here employed to derive a general kinetic solution that predicts
Externí odkaz:
https://doaj.org/article/256c2c3612eb4424a1914cd6f731eb3b
Self-recycling and partially conservative replication of mycobacterial methylmannose polysaccharides
Autor:
Ana Maranha, Mafalda Costa, Jorge Ripoll-Rozada, José A. Manso, Vanessa Miranda, Vera M. Mendes, Bruno Manadas, Sandra Macedo-Ribeiro, M. Rita Ventura, Pedro José Barbosa Pereira, Nuno Empadinhas
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
The mechanism of methylmannose polysaccharide (MMP) biogenesis in nontuberculous mycobacteria (NTM) is characterized, which involves an MMP-specific hydrolase (MmpH) and a rare mannosyltransferase (ManT). MmpH and ManT structures are presented.
Externí odkaz:
https://doaj.org/article/160414c28e904d199761ec1e0d62082e
Autor:
Carlos Pintado-Grima, Oriol Bárcenas, Zoe Manglano-Artuñedo, Rita Vilaça, Sandra Macedo-Ribeiro, Irantzu Pallarès, Jaime Santos, Salvador Ventura
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Proteome-wide analyses suggest that most globular proteins contain at least one amyloidogenic region, whereas these aggregation-prone segments are thought to be underrepresented in intrinsically disordered proteins (IDPs). In recent work, we reported
Externí odkaz:
https://doaj.org/article/482528cf6fe44e2db903fe137ee4afc7
Publikováno v:
Cells, Vol 12, Iss 6, p 826 (2023)
Unstable DNA repeat expansions and insertions have been found to cause more than 50 neurodevelopmental, neurodegenerative, and neuromuscular disorders. One of the main hallmarks of repeat expansion diseases is the formation of abnormal RNA or protein
Externí odkaz:
https://doaj.org/article/c388c7432f5f43d08e0688b5f5606c34
Autor:
Tatiana Barros Cereija, Susana Alarico, Eva C. Lourenço, José António Manso, M. Rita Ventura, Nuno Empadinhas, Sandra Macedo-Ribeiro, Pedro José Barbosa Pereira
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 572-585 (2019)
Bacteria are challenged to adapt to environmental variations in order to survive. Under nutritional stress, several bacteria are able to slow down their metabolism into a nonreplicating state and wait for favourable conditions. It is almost universal
Externí odkaz:
https://doaj.org/article/d9339f66918d4a6d955cb6d5bc351c33
Autor:
Francisco Figueiredo, Mónica Lopes-Marques, Bruno Almeida, Nena Matscheko, Pedro M. Martins, Alexandra Silva, Sandra Macedo-Ribeiro
Publikováno v:
Cells, Vol 11, Iss 12, p 1969 (2022)
Spinocerebellar ataxia type 3 (SCA3) is caused by the expansion of a glutamine repeat in the protein ataxin-3, which is deposited as intracellular aggregates in affected brain regions. Despite the controversial role of ataxin-3 amyloid structures in
Externí odkaz:
https://doaj.org/article/5a4287ff19704671a3bfafe9d598d75a
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 793 (2022)
A conserved, 26-residue sequence [AA(X2)[A/G][G/L](X2)GDV[I/L](X2)[V/L]NGE(X1)V(X6)] and corresponding structure repeating module were identified within the HtrA protease family using a non-redundant set (N = 20) of publicly available structures. Whi
Externí odkaz:
https://doaj.org/article/4f357178b60548e1956304812f4d1cdd