Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sandra M. W. van de Wiel"'
Autor:
Günter Fauler, John F. Gilmer, Paul A. Dawson, Sandra M. W. van de Wiel, Alex Zaufel, Tarek Moustafa, Lu Yin, Peter Fickert, Jennifer K. Truong, Daphne Chien, Stan F.J. van de Graaf, Xinzhong Dong
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1867(8):166153. Elsevier
Biochimica et biophysica acta. Molecular basis of disease
Biochimica et biophysica acta. Molecular basis of disease
IsoBAs, stereoisomers of primary and secondary BAs, are found in feces and plasma of human individuals. BA signaling via the nuclear receptor FXR is crucial for regulation of hepatic and intestinal physiology/pathophysiology. Aim: Investigate the abi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f659f989d335b18dfbf5106c9dd780b
https://pure.amc.nl/en/publications/secondary-isobas-cooperate-with-endogenous-ligands-to-activate-fxr-under-physiological-and-pathological-conditions(79ff6e65-2212-4c72-8711-b6600f0ceed2).html
https://pure.amc.nl/en/publications/secondary-isobas-cooperate-with-endogenous-ligands-to-activate-fxr-under-physiological-and-pathological-conditions(79ff6e65-2212-4c72-8711-b6600f0ceed2).html
Autor:
Sandra M. W. van de Wiel, Saskia W.C. van Mil, Stan F.J. van de Graaf, Ingrid T. G. W. Bijsmans
Publikováno v:
Scientific reports, 9(1):2193. Nature Publishing Group
Scientific Reports, 9(1), 2193. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports, 9(1), 2193. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
The farnesoid X receptor (FXR) belongs to the nuclear receptor family and is activated by bile acids. Multiple, chemically rather diverse, FXR agonists have been developed and several of these compounds are currently tested in clinical trials for NAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40764293b8d84edb491fd9c264bded4
https://pure.amc.nl/en/publications/identification-of-fdaapproved-drugs-targeting-the-farnesoid-x-receptor(b8501389-c62c-493f-8609-2b16b03d5b78).html
https://pure.amc.nl/en/publications/identification-of-fdaapproved-drugs-targeting-the-farnesoid-x-receptor(b8501389-c62c-493f-8609-2b16b03d5b78).html
Publikováno v:
AME Medical Journal, 3. AME Publishing Company
The liver has a remarkable capacity to regenerate itself after extensive loss of tissue. This regenerative capacity makes it possible to surgically remove large parts of the liver when a tumor is present (1). Furthermore, liver regeneration also enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc37061893d4a475d4d1bae1c40854a9
https://doi.org/10.21037/amj.2018.09.08
https://doi.org/10.21037/amj.2018.09.08
Autor:
Ronald P.J. Oude Elferink, D. Rudi de Waart, Sandra M. W. van de Wiel, Stan F.J. van de Graaf
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 5(3), 223-237. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 223-237 (2018)
Cellular and molecular gastroenterology and hepatology, 5(3), 223-237. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 223-237 (2018)
Background & Aims The organic solute transporter α-β (OSTα-OSTβ) mainly facilitates transport of bile acids across the basolateral membrane of ileal enterocytes. Therefore, inhibition of OSTα-OSTβ might have similar beneficial metabolic effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2148aac15134926b8e3da154af5a78f6
https://pubmed.ncbi.nlm.nih.gov/29675448
https://pubmed.ncbi.nlm.nih.gov/29675448
Publikováno v:
Journal of Visualized Experiments (JoVE). MYJoVE Corporation
ISSUE=107;ISSN=1940-087X;TITLE=Journal of Visualized Experiments (JoVE)
Journal of visualized experiments. MYJoVE Corporation
ISSUE=107;TITLE=Journal of visualized experiments
ISSUE=107;ISSN=1940-087X;TITLE=Journal of Visualized Experiments (JoVE)
Journal of visualized experiments. MYJoVE Corporation
ISSUE=107;TITLE=Journal of visualized experiments
Förster Resonance Energy Transfer (FRET) has become a powerful tool for monitoring protein folding, interaction and localization in single cells. Biosensors relying on the principle of FRET have enabled real-time visualization of subcellular signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a110a2d6c728995edb875830bcd73b
https://doi.org/10.3791/53659
https://doi.org/10.3791/53659
Publikováno v:
Expert Opinion on Drug Discovery, 9, 1293-306
Expert Opinion on Drug Discovery, 9, 11, pp. 1293-306
Expert Opinion on Drug Discovery, 9, 11, pp. 1293-306
Item does not contain fulltext INTRODUCTION: There are currently no treatments approved by the FDA to effectively treat cocaine dependence. Research of recent years has gradually revealed the importance of 5-hydroxytryptamine (5-HT) in the reinforcin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681f88cd06f9a6ef637c96c4a0f26072
https://pubmed.ncbi.nlm.nih.gov/25217125
https://pubmed.ncbi.nlm.nih.gov/25217125