Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Sandra M. Suzuka"'
Autor:
Min-Hui Cui, Henny H. Billett, Sandra M. Suzuka, Kamalakar Ambadipudi, Seetharama Archarya, Wenzhu B. Mowrey, Craig A. Branch
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 244
Fetal hemoglobin (HbF) is known to lessen the severity of sickle cell disease (SCD), through reductions in peripheral vaso-occlusive disease and reduced risk for cerebrovascular events. However, the influence of HbF on oxygen delivery to high metabol
Autor:
Shouping Zhang, Kai Wang, Karl Roberts, Emmanuel Olivier, Zi Yan, Eric E. Bouhassira, Sandra M. Suzuka
Many methods have been developed to produce red blood cellsin vitrobut translational applications have been hampered by the high cost of production. We have developed R6, a chemically-defined, albumin-free, low-transferrin culture medium, and MNC-RED
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db821fa7e09c14039aab4f6c0d0a35b3
https://doi.org/10.1101/616755
https://doi.org/10.1101/616755
Autor:
Eric E. Bouhassira, Shouping Zhang, Kai Wang, Zi Yan, Karl Roberts, Emmanuel Olivier, Sandra M. Suzuka
Cultured red blood cells (cRBCs) have many potential applications in transfusion medicine and drug delivery. We report that we have developed chemically defined, albumin-free Robust Erythroid Differentiation (RED) methods to produce enucleated cRBCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a687f9c5bd1520a9ca7c1ea3e0047245
https://doi.org/10.1101/616748
https://doi.org/10.1101/616748
Autor:
Eric E. Bouhassira, Emmanuel Olivier, Zi Yan, Shouping Zhang, Kai Wang, Sandra M. Suzuka, Karl Roberts
Publikováno v:
Experimental Hematology. 75:31-52.e15
Many methods have been developed to produce cultured red blood cells (cRBCs) in vitro but translational applications have been hampered by high costs of production and by low rates of enucleation. We have developed R6 and IMIT, two chemically defined
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H42-H50
Chronic inflammation is a salient feature of sickle cell disease (SCD) and transgenic-knockout sickle (BERK) mice. Inflammation is implicated in the activation of hypoxia-inducible factor-1α (HIF-1α) under normoxic conditions. We hypothesize that,
Autor:
Yelena Ginzburg, Leni von Bonsdorff, Mary E. Fabry, Eric E. Bouhassira, Charles B. Hall, William Breuer, Z. Ioav Cabantchik, Huihui Li, Anne C Rybicki, Sandra M. Suzuka
Publikováno v:
Nature Medicine. 16:177-182
Individuals with beta-thalassemia develop progressive systemic iron overload, resulting in high morbidity and mortality. These complications are caused by labile plasma iron, which is taken up by parenchymal cells in a dysregulated manner; in contras
Autor:
Rhoda Elison Hirsch, Arnaud Besse, Mary E. Fabry, Eric E. Bouhassira, Qiuying Chen, Ronald L. Nagel, Sandra M. Suzuka
Publikováno v:
Blood Cells, Molecules, and Diseases. 33:303-307
Hemoglobin E (HbE, beta26 Glu-->Lys) is the most common abnormal Hb variant in the world, and found in greatest frequency in Southeast (SE) Asia. In the United States, HbE is the third most prevalent variant (after HbS and HbC); and its now increasin
Publikováno v:
Magnetic Resonance in Medicine. 51:525-532
Neurological complications such as stroke are known consequences of sickle cell disease (SCD). In order to improve methods for the evaluation of stroke risk in SCD, MRI was used to evaluate cerebrovascular function in transgenic mouse models of human
Autor:
Nicholas A. Branch, Sandra M. Suzuka, Henny H. Billett, Seetharama A. Acharya, Sangeetha Thangaswamy, Min Hui Cui, Kamalakar Ambadipudi, Craig A. Branch
Publikováno v:
NMR in Biomedicine. 30:e3692
To characterize the cerebral profile associated with sickle cell disease (SCD), we used in vivo proton MRI and MRS to quantify hemodynamics and neurochemicals in the thalamus of NY1DD mice, a mild model of SCD, and compared them with wild-type (WT) c
Autor:
Seetharama A. Acharya, Amy G. Tsai, Marcos Intaglietta, Caterina P. Minniti, Sangeetha Thangaswamy, Savita Bhutoria, Sandra M. Suzuka, Craig A. Branch, Henny H. Billett, Prabhakaran Muthuchidambaram
Publikováno v:
Blood. 128:4845-4845
Background Surface decoration of Hb with PEG chains has been advanced as an approach to attenuate the vasoconstrictive activity of acellular Hb in circulation. PEGylated Hbs with higher oxygen affinities relative to unmodified Hb has an advantage whe