Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sandra M. Sims"'
Autor:
Eric M. Shobe, Jeffrey S. Day, Donald P. Smith, Joe Palandra, John D. Hosley, John J. Biermacher, Sandra M. Sims, Wade J. Adams, Philip S. Burton, Jana L. Jensen, Allen R. Hilgers, Janice M. Friis
Publikováno v:
Pharmaceutical Research. 20:1149-1155
Purpose. The purpose of this work was to evaluate an oral absorption prediction model, maximum absorbable dose (MAD), which predicts a theoretical dose of drug that could be absorbed across rat intestine based on consideration of intestinal permeabil
Autor:
Thomas J. Thamann, Jane E. Guido, Bowman Phil B, Kathleen A. Farley, Frank W. Crow, Brenda S. Vonderwell, Russell H. Robins, Gary E. Martin, Richard F. Smith, Wayne K. Duholke, Sandra M. Sims, Jay C. Brumfield
Publikováno v:
Magnetic Resonance in Chemistry. 36:S11-S16
A method is described for unequivocally establishing the site of N-oxidation which relies on the relatively large downfield shift of aliphatic nitrogen resonances following oxidation. The technique described is based on 15N at natural abundance and d
Autor:
Timothy G. Geary, C. L. Barsuhn, David P. Thompson, Eileen M. Thomas, Sandra M. Sims, N.F.H. Ho, J. S. Day
Publikováno v:
International Journal for Parasitology. 26:25-35
To determine if a cuticle microenvironment pH is maintained by adult Haemonchus contortus , organic acid excretion kinetics and absorption kinetics of selected model weak acids and a weak base were measured in incubation media that varied in buffer c
Autor:
Norman F.H. Ho, Eileen M. Thomas, Thomas J. Vidmar, David P. Thompson, Timothy G. Geary, Jeff S. Day, Sandra M. Sims, Craig L. Barsuhn
Publikováno v:
Journal of Pharmaceutical Sciences. 83:1052-1059
This multidisciplinary study demonstrates the utility of the biophysical model approach to assess biological activity of anthelmintics in light of drug-delivery principles. The relationships between drug absorption and efficacy for a set of structura
Publikováno v:
Parasitology Today. 9:31-35
In this article, David Thompson, Norman Ho, Sandra Sims and Timothy Geary look at the problem o f quantitating drug absorption by gastrointestinal nematodes.
Publikováno v:
Journal of Colloid and Interface Science. 155:210-220
Passive transport studies with net negatively charged model, porous membranes have shown that cationic solutes preferentially partition into the membrane relative to anionic solutes. In addition to direct electric field effects, iontophoretic transpo
Publikováno v:
Molecular and Biochemical Parasitology. 52:1-13
Using live, intact Ascaris suum and a closed perfusion system, the absorption kinetics and tissue distribution of selected radiolabeled permeants were measured to determine the importance of the transcuticular pathway for drug absorption. The data su
Publikováno v:
Pharmaceutical Research. :1402-1409
Total flux enhancement of ions during iontophoresis is due primarily to the electrochemical potential gradient. However, secondary effects such as convective solvent flow and, in biological membranes, permeability increases as a result of applied fie
Publikováno v:
International Journal of Pharmaceutics. 77:107-118
The enhanced transport of cations and anions across porous membranes under an applied electric field is found to be asymmetric. This asymmetry may be due to the interaction between the direct effect of the field and convective solvent flow, which has
Publikováno v:
International Journal of Pharmaceutics. 69:109-121
Overall flux enhancement of ions during iontophoresis is due primarily to the electrochemical potential gradient. However, secondary effects such as convective solvent flow and, in biological membranes, permeability increases due to the applied field