Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sandra M. Martín‐Guerrero"'
Autor:
Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) accumulations are hallmark pathologies of FTD/ALS and mutations in the
Externí odkaz:
https://doaj.org/article/959726ed7de941829423f9bf27ab624c
Autor:
Paula Cadenas-Garrido, Ailén Schonvandt-Alarcos, Lourdes Herrera-Quintana, Héctor Vázquez-Lorente, Alicia Santamaría-Quiles, Jon Ruiz de Francisco, Marina Moya-Escudero, David Martín-Oliva, Sandra M. Martín-Guerrero, César Rodríguez-Santana, Jerónimo Aragón-Vela, Julio Plaza-Diaz
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 127 (2024)
Antioxidant defenses in biological systems ensure redox homeostasis, regulating baseline levels of reactive oxygen and nitrogen species (ROS and RNS). Oxidative stress (OS), characterized by a lack of antioxidant defenses or an elevation in ROS and R
Externí odkaz:
https://doaj.org/article/f3666cdaa57b41068856727fd7501685
Autor:
Gábor M. Mórotz, Sandra M. Martín-Guerrero, Andrea Markovinovic, Sebastien Paillusson, Matthew R. G. Russell, Pedro M. Pereira Machado, Roland A. Fleck, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of fundamental physiological processes. This signaling involves close physical contacts between the two organelles that are mediated by the VAPB-PTPIP51 ″tethering
Externí odkaz:
https://doaj.org/article/39eaf584213b4fd8b1fbbb27b0353415
Autor:
Sandra M. Martín-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Shaakir Salam, Wendy Noble, Christopher C. J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two major neurodegenerative diseases. FTD is the second most common cause of dementia and ALS is the most common form of motor neuron disease. These diseases are now known to b
Externí odkaz:
https://doaj.org/article/53cde5ce80ed4175ad8c5d948bb33cbb
Autor:
Miguel A. Cuadros, Maruan Hijazi, David Martín-Oliva, Sandra M. Martín-Guerrero, Julio Plaza-Díaz, Julio Navascués, Francisco Abadía-Molina, Pedro R. Cutillas, Pedro Casado, Vinothini Rajeeve
Publikováno v:
Biochemical Journal. 477:4491-4513
Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyze the transfer of ADP-ribose units from NAD+ to several target proteins involved in cellular stress responses. Using WRL68 (HeLa derivate) cells, we previously showed that PARP-1
Autor:
Patricia Gomez‐Suaga, Gábor M. Mórotz, Andrea Markovinovic, Sandra M. Martín‐Guerrero, Elisavet Preza, Natalia Arias, Keith Mayl, Afra Aabdien, Vesela Gesheva, Agnes Nishimura, Ambra Annibali, Younbok Lee, Jacqueline C. Mitchell, Selina Wray, Christopher Shaw, Wendy Noble, Christopher C. J. Miller
Publikováno v:
Gomez Suaga, P, Morotz, G, Markovinovic, A, Martin Guerrero, S, Preza, E, Arias Del Castillo, N, Mayl, K, Aabdien, A, Gesheva, V, Nishimura, A, Annibali, A, Lee, Y, Mitchell, J, Wray, S, Shaw, C, Noble, W & Miller, C 2022, ' Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia ', AGING CELL, vol. 21, no. 2, e13549 . https://doi.org/10.1111/acel.13549
Hexanucleotide repeat expansions in C9orf72 are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by which the expansions cause disease are not properly understood but a favoured r
Autor:
Sandra M. Martín-Guerrero, José Antonio Muñoz-Gámez, Ana Cepero, David Martín-Oliva, Raúl Ortiz, David Urbano, Consolación Melguizo, Francisco Quiñonero, Jose Prados
Publikováno v:
Journal of biosciences. 46
Advanced-stage gastrointestinal tumors have high mortality due to chemotherapy limitations. One of the causes of treatment failure is the presence of cancer stem cells (CSCs), which show resistance mechanisms against DNA damage, such as poly (adenosi
Autor:
José Brea, Marta Cimadevila, Alba Iglesias, David Martín-Oliva, M. Isabel Loza, Pedro R. Cutillas, Juan F. López-Giménez, Javier González-Maeso, Sandra M. Martín-Guerrero, Paula Alonso, Pedro Casado
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Antipsychotic drugs remain the current standard for schizophrenia treatment. Although they directly recognize the orthosteric binding site of numerous monoaminergic G protein-coupled receptors (GPCRs), these drugs, and particularly second-generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5de8912403d5120941bb0a2b34e9dc
http://hdl.handle.net/10261/248807
http://hdl.handle.net/10261/248807
Autor:
Sandra M, Martín-Guerrero, Paula, Alonso, Alba, Iglesias, Marta, Cimadevila, José, Brea, M Isabel, Loza, Pedro, Casado, David, Martín-Oliva, Pedro R, Cutillas, Javier, González-Maeso, Juan F, López-Giménez
Publikováno v:
Biochemical pharmacology. 185
Antipsychotic drugs remain the current standard for schizophrenia treatment. Although they directly recognize the orthosteric binding site of numerous monoaminergic G protein-coupled receptors (GPCRs), these drugs, and particularly second-generation
Autor:
Pedro R. Cutillas, Miguel A. Cuadros, Juan F. López-Giménez, Julio Navascués, David Martín-Oliva, María-Carmen Carrasco, José Antonio Muñoz-Gámez, Pedro Casado, Sandra M. Martín-Guerrero
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Oxidative stress (OxS) is involved in the development of cell injures occurring in retinal diseases while Poly(ADP-ribose) Polymerase-1 (PARP-1) is a key protein involved in the repair of the DNA damage caused by OxS. Inhibition of PARP-1 activity wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b707e4d35c4a6b1fcd0dec1ec6774759
http://hdl.handle.net/10261/213615
http://hdl.handle.net/10261/213615