Výsledky vyhledávání - "Sandra M. Martín‐Guerrero"

Akademický článek

Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects

Autor: Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble, Christopher C.J. Miller

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)

Abstract Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) accumulations are hallmark pathologies of FTD/ALS and mutations in the

Externí odkaz: https://doaj.org/article/959726ed7de941829423f9bf27ab624c

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Akademický článek

Using Redox Proteomics to Gain New Insights into Neurodegenerative Disease and Protein Modification

Autor: Paula Cadenas-Garrido, Ailén Schonvandt-Alarcos, Lourdes Herrera-Quintana, Héctor Vázquez-Lorente, Alicia Santamaría-Quiles, Jon Ruiz de Francisco, Marina Moya-Escudero, David Martín-Oliva, Sandra M. Martín-Guerrero, César Rodríguez-Santana, Jerónimo Aragón-Vela, Julio Plaza-Diaz

Publikováno v: Antioxidants, Vol 13, Iss 1, p 127 (2024)

Antioxidant defenses in biological systems ensure redox homeostasis, regulating baseline levels of reactive oxygen and nitrogen species (ROS and RNS). Oxidative stress (OS), characterized by a lack of antioxidant defenses or an elevation in ROS and R

Externí odkaz: https://doaj.org/article/f3666cdaa57b41068856727fd7501685

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Akademický článek

The PTPIP51 coiled-coil domain is important in VAPB binding, formation of ER-mitochondria contacts and IP3 receptor delivery of Ca2+ to mitochondria

Autor: Gábor M. Mórotz, Sandra M. Martín-Guerrero, Andrea Markovinovic, Sebastien Paillusson, Matthew R. G. Russell, Pedro M. Pereira Machado, Roland A. Fleck, Wendy Noble, Christopher C.J. Miller

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of fundamental physiological processes. This signaling involves close physical contacts between the two organelles that are mediated by the VAPB-PTPIP51 ″tethering

Externí odkaz: https://doaj.org/article/39eaf584213b4fd8b1fbbb27b0353415

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Akademický článek

Targeting ER-Mitochondria Signaling as a Therapeutic Target for Frontotemporal Dementia and Related Amyotrophic Lateral Sclerosis

Autor: Sandra M. Martín-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Shaakir Salam, Wendy Noble, Christopher C. J. Miller

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two major neurodegenerative diseases. FTD is the second most common cause of dementia and ALS is the most common form of motor neuron disease. These diseases are now known to b

Externí odkaz: https://doaj.org/article/53cde5ce80ed4175ad8c5d948bb33cbb

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Akademický článek

Poly(ADP-ribose)polymerases inhibitors prevent early mitochondrial fragmentation and hepatocyte cell death induced by H2O2.

Autor: Sandra M Martín-Guerrero, José A Muñoz-Gámez, María-Carmen Carrasco, Javier Salmerón, María Martín-Estebané, Miguel A Cuadros, Julio Navascués, David Martín-Oliva

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0187130 (2017)

Poly(ADP-ribose)polymerases (PARPs) are a family of NAD+ consuming enzymes that play a crucial role in many cellular processes, most clearly in maintaining genome integrity. Here, we present an extensive analysis of the alteration of mitochondrial mo

Externí odkaz: https://doaj.org/article/72e6e1c809dc4483bd293ce073014ebd

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Akademický článek

Onset of microglial entry into developing quail retina coincides with increased expression of active caspase-3 and is mediated by extracellular ATP and UDP.

Autor: María Martín-Estebané, Julio Navascués, Ana Sierra-Martín, Sandra M Martín-Guerrero, Miguel A Cuadros, María-Carmen Carrasco, José L Marín-Teva

Publikováno v: PLoS ONE, Vol 12, Iss 8, p e0182450 (2017)

Microglial cell precursors located in the area of the base of the pecten and the optic nerve head (BP/ONH) start to enter the retina of quail embryos at the 7th day of incubation (E7), subsequently colonizing the entire retina by central-to-periphera

Externí odkaz: https://doaj.org/article/4602b66a2438433abb728453e42a3337

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PARP-1 activation after oxidative insult promotes energy stress-dependent phosphorylation of YAP1 and reduces cell viability

Autor: Miguel A. Cuadros, Maruan Hijazi, David Martín-Oliva, Sandra M. Martín-Guerrero, Julio Plaza-Díaz, Julio Navascués, Francisco Abadía-Molina, Pedro R. Cutillas, Pedro Casado, Vinothini Rajeeve

Publikováno v: Biochemical Journal. 477:4491-4513

Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme that catalyze the transfer of ADP-ribose units from NAD+ to several target proteins involved in cellular stress responses. Using WRL68 (HeLa derivate) cells, we previously showed that PARP-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104b7e1092c7daa50e04c90a9f84b2dc
https://doi.org/10.1042/bcj20200525

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Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia

Autor: Patricia Gomez‐Suaga, Gábor M. Mórotz, Andrea Markovinovic, Sandra M. Martín‐Guerrero, Elisavet Preza, Natalia Arias, Keith Mayl, Afra Aabdien, Vesela Gesheva, Agnes Nishimura, Ambra Annibali, Younbok Lee, Jacqueline C. Mitchell, Selina Wray, Christopher Shaw, Wendy Noble, Christopher C. J. Miller

Publikováno v: Gomez Suaga, P, Morotz, G, Markovinovic, A, Martin Guerrero, S, Preza, E, Arias Del Castillo, N, Mayl, K, Aabdien, A, Gesheva, V, Nishimura, A, Annibali, A, Lee, Y, Mitchell, J, Wray, S, Shaw, C, Noble, W & Miller, C 2022, ' Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia ', AGING CELL, vol. 21, no. 2, e13549 . https://doi.org/10.1111/acel.13549

Hexanucleotide repeat expansions in C9orf72 are the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The mechanisms by which the expansions cause disease are not properly understood but a favoured r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87469f549ade5e5a926eca0967b2b02d
https://pubmed.ncbi.nlm.nih.gov/35026048

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Akademický článek

Microglial Activation Promotes Cell Survival in Organotypic Cultures of Postnatal Mouse Retinal Explants.

Autor: Rosa M Ferrer-Martín, David Martín-Oliva, Ana Sierra-Martín, Maria-Carmen Carrasco, María Martín-Estebané, Ruth Calvente, Sandra M Martín-Guerrero, José L Marín-Teva, Julio Navascués, Miguel A Cuadros

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135238 (2015)

The role of microglia during neurodegeneration remains controversial. We investigated whether microglial cells have a neurotoxic or neuroprotective function in the retina. Retinal explants from 10-day-old mice were treated in vitro with minocycline t

Externí odkaz: https://doaj.org/article/752b35c5f85d4ea79b74faebcdb9e962

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