Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sandra M. Hayes"'
Autor:
Kevin P Nishimoto, Taylor Barca, Aruna Azameera, Amani Makkouk, Jason M Romero, Lu Bai, Mary M Brodey, Jackie Kennedy‐Wilde, Hui Shao, Stephanie Papaioannou, Amy Doan, Cynthia Masri, Ngoc T Hoang, Hayden Tessman, Vidhya Dhevi Ramanathan, Ana Giner‐Rubio, Frank Delfino, Kriti Sharma, Kevin Bray, Matthew Hoopes, Daulet Satpayev, Ranjita Sengupta, Marissa Herrman, Stewart E Abbot, Blake T Aftab, Zili An, Swapna Panuganti, Sandra M Hayes
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 2, Pp n/a-n/a (2022)
Abstract Objectives Autologous chimeric antigen receptor (CAR) αβ T‐cell therapies have demonstrated remarkable antitumor efficacy in patients with haematological malignancies; however, not all eligible cancer patients receive clinical benefit. E
Externí odkaz:
https://doaj.org/article/be2e5138abef45428e2a323fe55af735
Autor:
Elizabeth M Samuelson, Renee M Laird, Amber M Papillion, Arthur H Tatum, Michael F Princiotta, Sandra M Hayes
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92054 (2014)
BLK, which encodes B lymphoid kinase, was recently identified in genome wide association studies as a susceptibility gene for systemic lupus erythematosus (SLE), and risk alleles mapping to the BLK locus result in reduced gene expression. To determin
Externí odkaz:
https://doaj.org/article/bb4a206cad8e4e6db54149818cd371a6
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63178 (2013)
Both antigen recognition and CD28 costimulation are required for the activation of naïve αβ T cells and their subsequent differentiation into cytokine-producing or cytotoxic effectors. Notably, this two-signal paradigm holds true for all αβ T ce
Externí odkaz:
https://doaj.org/article/5265e596b7904d9e8d908262d967c4fa
Autor:
Renee M Laird, Sandra M Hayes
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8899 (2010)
Lck and Fyn, members of the Src family of tyrosine kinases, are key components of the alphabetaTCR-coupled signaling pathway. While it is generally accepted that both Lck and Fyn positively regulate signal transduction by the alphabetaTCR, recent stu
Externí odkaz:
https://doaj.org/article/25c3c9f4d32b4611b2e8d4b46adb8c37
Autor:
Sandra M. Hayes, Sattva S. Neelapu, Don A. Stevens, Francesco Galimi, Mehdi Hamadani, David B. Miklos
Publikováno v:
Blood. 138:2834-2834
In relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (NHL), the outcome of salvage therapies remains poor. Although autologous CD19-targeted chimeric antigen receptor (CAR) T-cell therapy is highly effective in R/R B cell NHL, only 40% achieve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6e08926597d4aadd06c5d95c57a82db
https://doi.org/10.1182/blood-2021-147581
https://doi.org/10.1182/blood-2021-147581
Autor:
Sandra M. Hayes, Renee M. Laird
Publikováno v:
Critical Reviews™ in Immunology. 32:81-95
Most effector T cells are generated in the periphery following an encounter with a foreign antigen and exposure to soluble and membrane-bound mediators. There are, however, some T cell subsets, such as γδ T cells and natural killer T cells, that ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a704b3e8fafedcb5abd1b9ce77b56e2
https://doi.org/10.1615/critrevimmunol.v32.i1.50
https://doi.org/10.1615/critrevimmunol.v32.i1.50
Publikováno v:
The Journal of Immunology. 185:6518-6527
The Ag receptors on αβ and γδ T cells differ not only in the nature of the ligands that they recognize but also in their signaling potential. We hypothesized that the differences in αβ- and γδTCR signal transduction were due to differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbc43af69604c0dd75efb76bdc4f9e80
https://doi.org/10.4049/jimmunol.1002766
https://doi.org/10.4049/jimmunol.1002766
Autor:
Emily K. Bongiorno, Carla Portocarrero, Trevor R. Baybutt, Ulrich Rodeck, Adam E. Snook, Sandra M. Hayes, Adam P. Dicker
Publikováno v:
Cancer Immunology Research. 6:B15-B15
Combining immunotherapy and radiation has emerged as a promising strategy to boost efficacy of diverse immunotherapeutic agents including tumor vaccines. Immuno-radiotherapy uses radiation to increase antigen exposure and, potentially, to amplify and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fbccb938b326d2134190f8dc6abc14e
https://doi.org/10.1158/2326-6074.tumimm17-b15
https://doi.org/10.1158/2326-6074.tumimm17-b15
Publikováno v:
Seminars in Immunology. 22:247-251
Signaling by the gammadelta T cell receptor (TCR) is required not only for alphabeta/gammadelta lineage commitment but also to activate and elicit effector functions in mature gammadelta T cells. Notably, at both of these stages, the signal delivered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e130e0736413589f9f57a0cb51051703
https://doi.org/10.1016/j.smim.2010.04.006
https://doi.org/10.1016/j.smim.2010.04.006
Autor:
Renee M. Laird, Sandra M. Hayes
Publikováno v:
Molecular Immunology. 47:582-589
The preTCR, gammadeltaTCR, and alphabetaTCR are the three isoforms of the T cell antigen receptor that are expressed during thymocyte development. Signaling by these isoforms is required at different stages of T cell development for lineage commitmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a23a504de302f6b518b9cc3eb775956
https://doi.org/10.1016/j.molimm.2009.09.015
https://doi.org/10.1016/j.molimm.2009.09.015