Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Sandra M. Bell"'
Autor:
Sophie E. Roberts, Heather L. Martin, Danah Al-Qallaf, Anna A. Tang, Christian Tiede, Thembaninkosi G. Gaule, Albor Dobon-Alonso, Ross Overman, Sachin Shah, Hadrien Peyret, Keith Saunders, Robin Bon, Iain W. Manfield, Sandra M. Bell, George P. Lomonossoff, Valerie Speirs, Darren C. Tomlinson
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110461- (2024)
Summary: Monoclonal antibodies have revolutionized therapies, but non-immunoglobulin scaffolds are becoming compelling alternatives owing to their adaptability. Their ability to be labeled with imaging or cytotoxic compounds and to create multimeric
Externí odkaz:
https://doaj.org/article/afbbfa1f915d4d408b05c261d3880b47
Autor:
Heather L. Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Sitthinon Siripanthong, Thomas L. Adams, Iain W. Manfield, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret A. Knowles, Richard W. Bayliss, Darren C. Tomlinson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113184- (2023)
Summary: Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition is highlighted by capturing
Externí odkaz:
https://doaj.org/article/602d6e2e2cea4be1917c7c7c7b34ebd6
Autor:
Mona Alsolami, Doaa Aboalola, Dolal Malibari, Tariq Alghamdi, Walaa Alshekhi, Hind Jad, Rea Rumbold-Hall, Ahlam S. Altowairqi, Sandra M. Bell, Rawiah Abdullah Alsiary
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The MCPH1 gene, also known as BRCT-repeat inhibitor of hTERT expression (BRIT1), has three BRCA1 carboxyl-terminal domains which is an important regulator of DNA repair, cell cycle checkpoints and chromosome condensation. MCPH1/BRIT1 is also known as
Externí odkaz:
https://doaj.org/article/4fb8bac4ca0f4db598a9dcfc5bc70fba
Autor:
Thomas A. Hughes, Eldo T. Verghese, Lucy F. Stead, Abeer M. Shaaban, Stacey J. Jones, Andrew M. Hanby, Sandra M. Bell, Diana E. Baxter, Lisa M. Allinson, Waleed S. Al Amri
Somatic variants data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce2c36ece86566607889e955ffc1494
https://doi.org/10.1158/1535-7163.22519098
https://doi.org/10.1158/1535-7163.22519098
Autor:
Thomas A. Hughes, Eldo T. Verghese, Lucy F. Stead, Abeer M. Shaaban, Stacey J. Jones, Andrew M. Hanby, Sandra M. Bell, Diana E. Baxter, Lisa M. Allinson, Waleed S. Al Amri
Supplementary information concerning: laser capture microscopy (Fig S1), efficiency of siRNA knock-down (Fig S2), results of siRNA knock-down for ABC gene expression and function (Fig S3), abilities of MUC17 and PCNX1 expression to define patient out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ac275e135431d4023f6231a8156b5e
https://doi.org/10.1158/1535-7163.22519101
https://doi.org/10.1158/1535-7163.22519101
Autor:
Thomas A. Hughes, Eldo T. Verghese, Lucy F. Stead, Abeer M. Shaaban, Stacey J. Jones, Andrew M. Hanby, Sandra M. Bell, Diana E. Baxter, Lisa M. Allinson, Waleed S. Al Amri
Poor-prognosis breast cancers are treated with cytotoxic chemotherapy, but often without any guidance from therapy predictive markers because universally accepted markers are not currently available. Treatment failure, in the form of recurrences, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cb3f015b5b0902de52081c2c0ffebcc
https://doi.org/10.1158/1535-7163.c.6542289
https://doi.org/10.1158/1535-7163.c.6542289
Autor:
Heather Louise Martin, Amy L. Turner, Julie Higgins, Anna A. Tang, Christian Tiede, Thomas Taylor, Thomas L. Adams, Sandra M. Bell, Ewan E. Morrison, Jacquelyn Bond, Chi H. Trinh, Carolyn D. Hurst, Margaret Knowles, Richard Bayliss, Darren C. Tomlinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8917ff9c581be0aeeeaa231bf174caa
https://doi.org/10.2139/ssrn.4350139
https://doi.org/10.2139/ssrn.4350139
Autor:
Lucy F. Stead, Abeer M Shaaban, Stacey J. Jones, Lisa M. Allinson, Thomas A. Hughes, Sandra M. Bell, Andrew M. Hanby, Waleed S. Al Amri, Diana E. Baxter, Eldo T. Verghese
Publikováno v:
Molecular Cancer Therapeutics. 19:945-955
Poor-prognosis breast cancers are treated with cytotoxic chemotherapy, but often without any guidance from therapy predictive markers because universally accepted markers are not currently available. Treatment failure, in the form of recurrences, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64df56d9e890c9b40aa368142d63158e
https://doi.org/10.1158/1535-7163.mct-19-0940
https://doi.org/10.1158/1535-7163.mct-19-0940
Autor:
Mohammed Derar, Emma C. Lord, James A. Poulter, Andrew R. Webster, Sandra M. Bell, Chris F. Inglehearn, Carmel Toomes
Publikováno v:
Acta Ophthalmologica. 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4163e367788463b3396e9b215b38ae
https://doi.org/10.1111/j.1755-3768.2022.208
https://doi.org/10.1111/j.1755-3768.2022.208
Autor:
Heather L Martin, Matthew Adams, Julie Higgins, Jacquelyn Bond, Ewan E Morrison, Sandra M Bell, Stuart Warriner, Adam Nelson, Darren C Tomlinson
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88338 (2014)
Toxicity is a major cause of failure in drug discovery and development, and whilst robust toxicological testing occurs, efficiency could be improved if compounds with cytotoxic characteristics were identified during primary compound screening. The us
Externí odkaz:
https://doaj.org/article/662c944ba0d54a6e9808ab389a227357