Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs.

Autor: Sandra M Skovdal, Stig Hill Christiansen, Karen Singers Johansen, Ole Viborg, Niels Henrik Bruun, Søren Jensen-Fangel, Ida Elisabeth Holm, Thomas Vorup-Jensen, Eskild Petersen

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223647 (2019)

The developmental speed of new antimicrobials does not meet the emergence of multidrug-resistant bacteria sufficiently. A potential shortcut is assessing the antimicrobial activity of already approved drugs. Intrudingly, the antibacterial action of g

Externí odkaz: https://doaj.org/article/7d42a65bd6d94152b8ccd00ab6ec56ba

Host factors abolish the need for polysaccharides and extracellular matrix-binding protein in Staphylococcus epidermidis biofilm formation

Autor: Henning Büttner, Liva Kjær Hansen, Guanghong Zeng, Nis Pedersen Jørgensen, Rikke Louise Meyer, Sandra M. Skovdal, Diana Malskær Ivarsen, Holger Rohde

Publikováno v: Skovdal, S M, Hansen, L K, Ivarsen, D M, Zeng, G, Büttner, H, Rohde, H, Jørgensen, N P & Meyer, R L 2021, ' Host factors abolish the need for polysaccharides and extracellular matrix-binding protein in Staphylococcus epidermidis biofilm formation ', Journal of Medical Microbiology, vol. 70, no. 3, 001287 . https://doi.org/10.1099/jmm.0.001287

Introduction. Staphylococcus epidermidis is predominant in implant-associated infections due to its capability to form biofilms. It can deploy several strategies for biofilm development using either polysaccharide intercellular adhesin (PIA), extrace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0dfd71446a9b5fe17c1524537f6cee0
https://pure.au.dk/portal/da/publications/host-factors-abolish-the-need-for-polysaccharides-and-extracellular-matrixbinding-protein-in-staphylococcus-epidermidis-biofilm-formation(bea19448-194f-4abd-86fe-cd3f63f28c23).html

Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs

Autor: Eskild Petersen, Ole Viborg, Thomas Vorup-Jensen, Karen Singers Eiskjær Johansen, Stig Hill Christiansen, Sandra M. Skovdal, Ida Elisabeth Holm, Niels Henrik Bruun, Søren Jensen-Fangel

Publikováno v: Skovdal, S M, Hill Christiansen, S, Singers Johansen, K, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, J E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', P L o S One, vol. 14, no. 10, e0223647 . https://doi.org/10.1371/journal.pone.0223647
PLoS ONE
Skovdal, S M, Christiansen, S H, Johansen, K S, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', PLOS ONE, vol. 14, no. 10, e0223647 . https://doi.org/10.1371/journal.pone.0223647
Skovdal, S M, Christiansen, S H, Johansen, K S, Viborg, O, Bruun, N H, Jensen-Fangel, S, Holm, I E, Vorup-Jensen, T & Petersen, E 2019, ' Inhaled nebulized glatiramer acetate against Gram-negative bacteria is not associated with adverse pulmonary reactions in healthy, young adult female pigs ', PLOS ONE, vol. 14, no. 10, pp. e0223647 . https://doi.org/10.1371/journal.pone.0223647
PLoS ONE, Vol 14, Iss 10, p e0223647 (2019)

The developmental speed of new antimicrobials does not meet the emergence of multidrugresistant bacteria sufficiently. A potential shortcut is assessing the antimicrobial activity of already approved drugs. Intrudingly, the antibacterial action of gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b083550dc64d51b458de55a19f825cd
https://findresearcher.sdu.dk:8443/ws/files/154913975/journal.pone.0223647.pdf

The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria

Autor: Thomas Vorup-Jensen, Marlene Fredborg, Michael Lykke Hvam, Rikke Louise Meyer, R.A. Murphy, Mihaela Gadjeva, Jens R. Nyengaard, Arne Möller, Stig Hill Christiansen, M. Wang, Sandra M. Skovdal, Kenneth A. Howard, Eskild Petersen, Jane C. Davies, Kristian Juul-Madsen, Uffe B. Skov Sørensen, Esben Axelgaard, Niels Nørskov-Lauritsen

Publikováno v: Hill Christiansen, S, Murphy, R A, Juul-Madsen, K, Fredborg, M, Hvam, M L, Axelgaard, E, Skovdal, S M, Meyer, R L, Sørensen, U B S, Möller, A, Nyengaard, J R, Nørskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, K A, Davies, J C, Petersen, E & Vorup-Jensen, T 2017, ' The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria ', Scientific Reports, vol. 7, 15653 . https://doi.org/10.1038/s41598-017-15969-3
Christiansen, S H, Murphy, R A, Juul-Madsen, K, Fredborg, M, Hvam, M L, Axelgaard, E, Skovdal, S M, Meyer, R L, Sorensen, U B S, Moeller, A, Nyengaard, J R, Norskov-Lauritsen, N, Wang, M, Gadjeva, M, Howard, K A, Davies, J C, Petersen, E & Vorup-Jensen, T 2017, ' The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria ', Scientific Reports, vol. 7, 15653 . https://doi.org/10.1038/s41598-017-15969-3
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Scientific Reports

Classic drug development strategies have failed to meet the urgent clinical needs in treating infections with Gram-negative bacteria. Repurposing drugs can lead to timely availability of new antibiotics, accelerated by existing safety profiles. Glati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99382febee1c7502b41664ee0b7018f
https://doi.org/10.1038/s41598-017-15969-3