Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sandra M Penz"'
Autor:
Anna L. Khandoga, Sandra M Penz, Richard Brandl, Wolfgang Siess, Takayuki Maruyama, Suman Dwivedi, Lisa J. Schober
Publikováno v:
Journal of Thrombosis and Thrombolysis. 32:158-166
Atherosclerosis has an important inflammatory component. Macrophages accumulating in atherosclerotic arteries produce prostaglandin E(2) (PGE(2)), a main inflammatory mediator. Platelets express inhibitory receptors (EP(2), EP(4)) and a stimulatory r
Autor:
Martin Schaller, Karin Müller, Götz Münch, Dagmar Menzel, Thomas Simmet, Tanja Schönberger, Berthold Büchele, Christoph Leder, Dorothea Siegel-Axel, Sandra M Penz, Meinrad Gawaz, Stephan Lindemann, Andreas Bültmann, Karin Daub, Peter Seizer
Publikováno v:
Daub, K, Siegel-Axel, D, Schönberger, T, Leder, C, Seizer, P, Müller, K, Schaller, M, Penz, S, Menzel, D, Buchele, B, Bültmann, A, Münch, G, Lindemann, S, Simmet, T & Gawaz, M 2010, ' Inhibition of foam cell formation using a soluble CD68-Fc fusion protein ', Journal of Molecular Medicine, vol. 88, no. 9, pp. 909-920 . https://doi.org/10.1007/s00109-010-0629-y
Daub, K, Siegel-Axel, D, Schönberger, T, Leder, C, Seizer, P, Müller, K, Schaller, M, Penz, S, Menzel, D, Büchele, B, Bültmann, A, Münch, G, Lindemann, S, Simmet, T & Gawaz, M 2010, ' Inhibition of foam cell formation using a soluble CD68-Fc fusion protein ' Journal of Molecular Medicine, vol 88, no. 9, pp. 909-920 . DOI: 10.1007/s00109-010-0629-y
Daub, K, Siegel-Axel, D, Schönberger, T, Leder, C, Seizer, P, Müller, K, Schaller, M, Penz, S, Menzel, D, Büchele, B, Bültmann, A, Münch, G, Lindemann, S, Simmet, T & Gawaz, M 2010, ' Inhibition of foam cell formation using a soluble CD68-Fc fusion protein ' Journal of Molecular Medicine, vol 88, no. 9, pp. 909-920 . DOI: 10.1007/s00109-010-0629-y
The appearance of lipid-rich foam cells is a major feature of vulnerable atherosclerotic plaque formation. The transformation of macrophages into foam cells results from excessive uptake of cholesterol-rich particles by scavenger receptors such as CD
Autor:
Harald F. Langer, Sandra M Penz, Konstantinos Stellos, Stefan Seidl, Christof Hoffmann, Richard Brandl, Tanja Schönberger, Angelika Gillitzer, Steffen Massberg, Elisabeth Kremmer, Simon Schneider, Meinrad Gawaz, Wolfgang Siess, Christian Schulz, Bernd J. Pichler
Publikováno v:
Basic Research in Cardiology. 103:356-367
Platelet adhesion to the atherosclerotic vascular wall induces thrombosis and boosters vascular inflammation and atheroprogression. In the present study we studied the binding of the platelet collagen receptor glycoprotein (GP) VI to human atheroscle
Autor:
Wolfgang Siess, Armin J. Reininger, Hans Deckmyn, Sandra M Penz, Richard Brandl, Orsolya Tóth
Publikováno v:
Thrombosis and Haemostasis. 97:435-443
Anti-platelet drugs are used to prevent intra-arterial thrombus formation after rupture of atherosclerotic plaques. Until now, the inhibitory effect of present and future anti-platelet drugs such as aspirin, ADP receptor P2Y(1)/P2Y(12) antagonists an
Autor:
Bernd Engelmann, Bernhard Nieswandt, Peter A. Smethurst, Richard Brandl, Sandra M Penz, Richard W. Farndale, Armin J. Reininger, Isabell Bernlochner, Pankaj Goyal, Tamer Rabie, Wolfgang Siess, Enno Rother, Christine A. Goetz, Willem H. Ouwehand
Publikováno v:
The FASEB Journal. 19:898-909
Lipid-rich atherosclerotic plaques are vulnerable, and their rupture can cause the formation of a platelet- and fibrin-rich thrombus leading to myocardial infarction and ischemic stroke. Although the role of plaque-based tissue factor as stimulator o
Autor:
Armin J. Reininger, Peter A. Smethurst, Wolfgang Siess, Isabell Bernlochner, Catherine Ravanat, Richard Brandl, Sandra M Penz, Christian Gachet, Richard W. Farndale
Publikováno v:
Journal of the American College of Cardiology. 55(11)
Objectives The aim of this study was to understand the initial mechanism of arterial thrombus formation induced by vulnerable human atherosclerotic plaques to re-assess and improve current antithrombotic strategies. Background Rupture of atherosclero
Autor:
Sandra M, Penz, Armin J, Reininger, Orsolya, Toth, Hans, Deckmyn, Richard, Brandl, Wolfgang, Siess
Publikováno v:
Thrombosis and haemostasis. 97(3)
Anti-platelet drugs are used to prevent intra-arterial thrombus formation after rupture of atherosclerotic plaques. Until now, the inhibitory effect of present and future anti-platelet drugs such as aspirin, ADP receptor P2Y(1)/P2Y(12) antagonists an
Publikováno v:
Thrombosis and haemostasis. 96(6)
SummarySeveral methods are used to analyse platelet function in whole blood. A new device to measure whole blood platelet aggregation has been developed, called multiple electrode platelet aggregometry (MEA). Our aim was to evaluate MEA in comparison
Publikováno v:
Thrombosis and Haemostasis. 103:1268-1269
The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood
Autor:
Richard Brandl, Christine A. Goetz, Tamer Rabie, Richard W. Farndale, Wolfgang Siess, Bernd Engelmann, Enno Rother, Bernhard Nieswandt, Pankaj Goyal, Sandra M Penz, Armin J. Reininger
Publikováno v:
Blood. 104:2623-2623
Lipid-rich atherosclerotic plaques are vulnerable, and upon disruption trigger intraarterial thrombus formation. Tissue factor activating blood coagulation is viewed as the major prothrombotic stimulus within the plaque. We isolated lipid-rich athero