Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sandra M Holley"'
Autor:
Ana C Sias, Ashleigh K Morse, Sherry Wang, Venuz Y Greenfield, Caitlin M Goodpaster, Tyler M Wrenn, Andrew M Wikenheiser, Sandra M Holley, Carlos Cepeda, Michael S Levine, Kate M Wassum
Publikováno v:
eLife, Vol 10 (2021)
Adaptive reward-related decision making often requires accurate and detailed representation of potential available rewards. Environmental reward-predictive stimuli can facilitate these representations, allowing one to infer which specific rewards mig
Externí odkaz:
https://doaj.org/article/f13e8ca44fc446ad953247be2041e83e
Autor:
Samuel S Pappas, Katherine Darr, Sandra M Holley, Carlos Cepeda, Omar S Mabrouk, Jenny-Marie T Wong, Tessa M LeWitt, Reema Paudel, Henry Houlden, Robert T Kennedy, Michael S Levine, William T Dauer
Publikováno v:
eLife, Vol 4 (2015)
Striatal dysfunction plays an important role in dystonia, but the striatal cell types that contribute to abnormal movements are poorly defined. We demonstrate that conditional deletion of the DYT1 dystonia protein torsinA in embryonic progenitors of
Externí odkaz:
https://doaj.org/article/9d4d4dc0369b4370b4eceffea8ccb288
Publikováno v:
ASN Neuro, Vol 2 (2010)
The discovery of the HD (Huntington's disease) gene in 1993 led to the creation of genetic mouse models of the disease and opened the doors for mechanistic studies. In particular, the early changes and progression of the disease could be followed and
Externí odkaz:
https://doaj.org/article/b26d95436b264df4ad060f5f8eb98f81
Autor:
Kwang Lee, Konstantin I. Bakhurin, Leslie D. Claar, Sandra M. Holley, Natalie C. Chong, Carlos Cepeda, Michael S. Levine, Sotiris C. Masmanidis
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2438-2449.e4 (2019)
Summary: The cortex and thalamus send excitatory projections to the striatum, but little is known about how these inputs, either individually or collectively, regulate striatal dynamics during behavior. The lateral striatum receives overlapping input
Externí odkaz:
https://doaj.org/article/6687792c86704d40893e8394ebcf8d59
Autor:
Carlos Cepeda, Sherry Wang, Michael Levine, Ashleigh K Morse, Andrew M. Wikenheiser, Tyler M Wrenn, Ana C Sias, Venuz Y. Greenfield, Kate M. Wassum, Sandra M. Holley, Caitlin M Goodpaster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6f6ea21152e9aeddb845807d8f3785
https://doi.org/10.7554/elife.68617.sa2
https://doi.org/10.7554/elife.68617.sa2
Autor:
Ashleigh K Morse, Caitlin M Goodpaster, Carlos Cepeda, Venuz Y. Greenfield, Kate M. Wassum, Andrew M. Wikenheiser, Sandra M. Holley, Tyler M Wrenn, Ana C Sias, Sherry Wang, Michael S. Levine
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Adaptive reward-related decision making often requires accurate and detailed representation of potential available rewards. Environmental reward-predictive stimuli can facilitate these representations, allowing one to infer which specific rewards mig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1108cf93a4b57b626f6057dcff1d961
http://europepmc.org/articles/PMC8266390
http://europepmc.org/articles/PMC8266390
Publikováno v:
Eur J Neurosci
The pathological hallmark of Huntington’s disease (HD) is the massive loss of striatal and cortical neurons. Until recently, it was believed that striatal interneurons were spared from degeneration. This view has changed after the demonstration tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afab3b63d606e5522a3b756d6d88ddc9
https://doi.org/10.1111/ejn.14283
https://doi.org/10.1111/ejn.14283
Autor:
Venuz Y. Greenfield, Kate M. Wassum, Caitlin M Goodpaster, Carlos Cepeda, Michael S. Levine, Tyler M Wrenn, Andrew M. Wikenheiser, Ashleigh K Morse, Sherry Wang, Ana C Sias, Sandra M. Holley
Adaptive reward-related decision making often requires accurate and detailed representation of potential available rewards. Environmental reward-predictive stimuli can facilitate these representations, allowing one to infer which specific rewards mig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be35b712bf62acb37489df3ade02b3dd
https://doi.org/10.1101/2021.03.20.436233
https://doi.org/10.1101/2021.03.20.436233
Autor:
Maile C. Neel, Lexi Kopan, Cynthia Moore, Charles K. Meshul, Sylvia Y. Yeung, Sandra M. Holley, Gerhard Bauer, Jack C. Reidling, Michael Levine, Leslie M. Thompson, Edwin S. Monuki, Brian Fury, Carlos Cepeda, Dane P. Coleal‐Bergum, Alice Lau, Iliana Orellana
Huntington’s disease (HD), a genetic neurodegenerative disorder, primarily impacts the striatum and cortex with progressive loss of medium-sized spiny neurons (MSNs) and pyramidal neurons, disrupting cortico-striatal circuitry. A promising regenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f00cdf5b6f06032059564fd9cee1f3
https://doi.org/10.1101/2021.01.18.427078
https://doi.org/10.1101/2021.01.18.427078
Autor:
Michael S. Levine, Leslie M. Thompson, Gerhard Bauer, Carlos Cepeda, Talia Kamdjou, Dane P. Coleal‐Bergum, Jack C. Reidling, Brian Fury, Sandra M. Holley
Publikováno v:
CNS neuroscience & therapeutics, vol 24, iss 4
The principal symptoms of Huntington's disease (HD), chorea, cognitive deficits, and psychiatric symptoms are associated with the massive loss of striatal and cortical projection neurons. As current drug therapies only partially alleviate symptoms, f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec08f1eb155bf7d6a45eac24f34bca0
https://doi.org/10.1111/cns.12839
https://doi.org/10.1111/cns.12839