Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Sandra Larkin"'
Autor:
Claudia R. Morris, Frans A. Kuypers, Robert Hagar, Sandra Larkin, Lisa Lavrisha, Augusta Saulys, Elliott P. Vichinsky, Jung H. Suh
Publikováno v:
Complementary Therapies in Medicine, Vol 64, Iss , Pp 102803- (2022)
Objectives: L-Glutamine is FDA-approved for sickle cell disease (SCD), yet the mechanism(s)-of-action are poorly understood. We performed a pharmacokinetics (pK) study to determine the metabolic fate of glutamine supplementation on plasma and erythro
Externí odkaz:
https://doaj.org/article/9bed86b6c7124eceb1325cd9253e7c0e
Autor:
Claudia R. Morris, Hae-Young Kim, John Wood, John B. Porter, Elizabeth S. Klings, Felicia L. Trachtenberg, Nancy Sweeters, Nancy F. Olivieri, Janet L. Kwiatkowski, Lisa Virzi, Sylvia T. Singer, Ali Taher, Ellis J. Neufeld, Alexis A. Thompson, Vandana Sachdev, Sandra Larkin, Jung H. Suh, Frans A. Kuypers, Elliott P. Vichinsky
Publikováno v:
Haematologica, Vol 98, Iss 9 (2013)
Pulmonary hypertension is a common but often overlooked complication associated with thalassemia syndromes. There are limited data on the safety and efficacy of selective pulmonary vasodilators in this at-risk population. We, therefore, designed a 12
Externí odkaz:
https://doaj.org/article/8cbedfd01cee4469b89b63927e5faa58
Autor:
Stuart Smith, Andrzej Witkowski, Ayesha Moghul, Yuko Yoshinaga, Michael Nefedov, Pieter de Jong, Dejiang Feng, Loren Fong, Yiping Tu, Yan Hu, Stephen G Young, Thomas Pham, Carling Cheung, Shana M Katzman, Martin D Brand, Casey L Quinlan, Marcel Fens, Frans Kuypers, Stephanie Misquitta, Stephen M Griffey, Son Tran, Afshin Gharib, Jens Knudsen, Hans Kristian Hannibal-Bach, Grace Wang, Sandra Larkin, Jennifer Thweatt, Saloni Pasta
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47196 (2012)
A mouse model with compromised mitochondrial fatty acid synthesis has been engineered in order to assess the role of this pathway in mitochondrial function and overall health. Reduction in the expression of mitochondrial malonyl CoA-acyl carrier prot
Externí odkaz:
https://doaj.org/article/9075ccbc571d4a01888a6b5716bb334c
Publikováno v:
Exp Biol Med (Maywood)
Vincristine, a vinca alkaloid, is widely used in many hematologic disorders and pediatric cancers, and acts by binding to the tubulin protein, to inhibit effective cell division. Vincristine-induced anemia has been observed, but its mechanism is not
Autor:
Kari Wheeler, Jared Hershenson, Ana Lucia Cortez, Angela Lewis, Sandra Larkin, Sangah Nancy Park, Vivian Phan, Noravy Briere, Robin Yates Dulman, Elizabeth Yang, Laura Caldarera, Frans A. Kuypers
Publikováno v:
Blood. 138:2045-2045
Background/Hypothesis: Children and adults with sickle cell anemia (SCA) exhibit decreased cardiopulmonary fitness. Anemia is directly related to oxygen carrying capacity and is one factor that affects cardiopulmonary fitness. The new sickle cell dru
Publikováno v:
Experimental Biology and Medicine. 242:1244-1253
In sickle cell disease (SCD), alterations of cholesterol metabolism is in part related to abnormal levels and activity of plasma proteins such as lecithin cholesterol acyltransferase (LCAT), and apolipoprotein A-I (ApoA-I). In addition, the size dist
Autor:
Carolyn Hoppe, Lori Styles, Eufemia Jacob, Sandra Larkin, Frans A. Kuypers, Elliott Vichinsky
Publikováno v:
British Journal of Haematology. 177:620-629
Summary Sickle cell anaemia (SCA) is a progressive vascular disease characterized by episodic vaso-occlusive pain. Despite the broad impact of inflammation on acute and chronic clinical manifestations of SCA, no directed anti-inflammatory therapies c
Autor:
Sandra Larkin, Ozlem Yalcin, Polat Goktas, Ayhan Altintas, Ilya O. Sukharevsky, Frans A. Kuypers
Publikováno v:
Cytometry Part A
Red blood cells (RBCs) from sickle cell patients exposed to a low oxygen tension reveal highly heterogeneous cell morphologies due to the polymerization of sickle hemoglobin (HbS). We show that angle‐resolved light scattering approach with the use
Autor:
Eric Soupene, Lynne Neumayr, Sandra Larkin, Elliott Vichinsky, Frans A. Kuypers, Madhav Vissa
Publikováno v:
Blood. 136:15-15
Introduction: Heme, an iron-containing protoporphyrin, is an essential component of hemoglobin that binds oxygen for delivery to tissues. In sickle cell disease, intravascular hemolysis leads to the presence of cell-free hemoglobin and heme, which ma
Autor:
Howard M. Rosenfeld, Frans A. Kuypers, James N. Huang, Gregory Kurio, Ginny Gildengorin, Elliott Vichinsky, Sandra Larkin, Annie Higa, Michael Jeng, Nancy Sweeters, Sylvia T. Singer, Jeffery R. Fineman
Publikováno v:
Annals of hematology, vol 93, iss 7
A high tricuspid regurgitant jet velocity (TRV) signifies a risk for or established pulmonary hypertension (PH), which is a serious complication in thalassemia patients. The underlying pathophysiology in thalassemia subgroups and potential biomarkers