Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients

Autor: Tatjana Nikolic, Jessica S. Suwandi, Joris Wesselius, Sandra Laban, Antoinette M. Joosten, Petra Sonneveld, Dick Mul, Henk-Jan Aanstoot, John S. Kaddis, Jaap Jan Zwaginga, Bart O. Roep

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

IntroductionRestoration of immune tolerance may halt progression of autoimmune diseases. Tolerogenic dendritic cells (tolDC) inhibit antigen-specific proinflammatory T-cells, generate antigen-specific regulatory T-cells and promote IL-10 production i

Externí odkaz: https://doaj.org/article/6b30cbbe941d482d958e523b9eb75cf6

Heterogeneity of circulating CD8 T-cells specific to islet, neo-antigen and virus in patients with type 1 diabetes mellitus.

Autor: Sandra Laban, Jessica S Suwandi, Vincent van Unen, Jos Pool, Joris Wesselius, Thomas Höllt, Nicola Pezzotti, Anna Vilanova, Boudewijn P F Lelieveldt, Bart O Roep

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0200818 (2018)

Auto-reactive CD8 T-cells play an important role in the destruction of pancreatic β-cells resulting in type 1 diabetes (T1D). However, the phenotype of these auto-reactive cytolytic CD8 T-cells has not yet been extensively described. We used high-di

Externí odkaz: https://doaj.org/article/3e4e8682f1314207843c9d30ad930833

A unique immune signature in blood separates therapy-refractory from therapy-responsive acute graft-versus-host disease

Autor: Astrid G. S. van Halteren, Jessica S. Suwandi, Sander Tuit, Jelske Borst, Sandra Laban, Roula Tsonaka, Ada Struijk, Anna-Sophia Wiekmeijer, Melissa van Pel, Bart O. Roep, Jaap Jan Zwaginga, Arjan C. Lankester, Koen Schepers, Maarten J. D. van Tol, Willem E. Fibbe

Publikováno v: Blood. 141(11):1277-1292

Acute graft-versus-host disease (aGVHD) is an immune cell‒driven, potentially lethal complication of allogeneic hematopoietic stem cell transplantation affecting diverse organs, including the skin, liver, and gastrointestinal (GI) tract. We applied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4806f577f9ab625e12cf2e9aa317027
https://doi.org/10.1182/blood.2022015734

GPA33 is expressed on multiple human blood cell types and distinguishes CD4+ central memory T cells with and without effector function

Autor: Bart O. Roep, Rianne Opstelten, Tatjana Nikolic, Derk Amsen, Carlijn Voermans, Annelies W. Turksma, Andrew M. Scott, Anna Kroeze, Sandra Laban, Manon C. Slot, Florencia Morgana, Jessica S. Suwandi, Jaap-Jan Zwaginga

Publikováno v: European journal of immunology, 51(6), 1377-1389. Wiley-VCH Verlag
European Journal of Immunology, 51(6), 1377-1389. WILEY
European Journal of Immunology

The Ig superfamily protein glycoprotein A33 (GPA33) has been implicated in immune dysregulation, but little is known about its expression in the immune compartment. Here, we comprehensively determined GPA33 expression patterns on human blood leukocyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03a50634d795e54714c1225b8e7ac64
https://pure.amc.nl/en/publications/gpa33-is-expressed-on-multiple-human-blood-cell-types-and-distinguishes-cd4-central-memory-t-cells-with-and-without-effector-function(101849ce-5900-4d4f-9bfc-38a8f66f7601).html

Author response for 'GPA33 is expressed on multiple human blood cell types and distinguishes CD4 + central memory T cells with and without effector function'

Autor: null Rianne Opstelten, null Jessica S Suwandi, null Manon C. Slot, null Florencia Morgana, null Andrew M Scott, null Sandra Laban, null Tatjana Nikolic, null Annelies W Turksma, null Anna Kroeze, null Carlijn Voermans, null Jaap‐Jan Zwaginga, null Bart O Roep, null Derk Amsen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a759749147c5eee0fc4db764db685371
https://doi.org/10.1002/eji.202048744/v2/response1