Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sandra L. Todero"'
Autor:
Kusum K. Kharbanda, Sandra L. Todero, Adrienne L. King, Natalia A. Osna, Benita L. McVicker, Dean J. Tuma, James L. Wisecarver, Shannon M. Bailey
Publikováno v:
International Journal of Hepatology, Vol 2012 (2012)
Introduction. Mitochondrial damage and disruption in oxidative phosphorylation contributes to the pathogenesis of alcoholic liver injury. Herein, we tested the hypothesis that the hepatoprotective actions of betaine against alcoholic liver injury occ
Externí odkaz:
https://doaj.org/article/6743cadb2f644066b57fbf4fe06b511a
Autor:
David J. Orlicky, Samuel W. French, Sandra L. Todero, Dean J. Tuma, Kusum K. Kharbanda, Natalia A. Osna, Paul G. Thomes
Publikováno v:
Experimental and Molecular Pathology. 97:49-56
We previously reported that chronic ethanol intake lowers hepatocellular S-adenosylmethionine to S-adenosylhomocysteine ratio and significantly impairs many liver methylation reactions. One such reaction, catalyzed by guanidinoacetate methyltransfera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d3a29ae2b334e2b2a9c581ebc73b2a
https://doi.org/10.1016/j.yexmp.2014.05.006
https://doi.org/10.1016/j.yexmp.2014.05.006
Autor:
Kusum K. Kharbanda, Paul G. Thomes, Sandra L. Todero, Ryan M. Harris, Natalia A. Osna, Jordan C. Moats, Dean J. Tuma
Publikováno v:
Alcoholism: Clinical and Experimental Research. 38:641-648
We have previously shown that decreased S-adenosylmethionine (SAM):S-adenosylhomocysteine (SAH) ratio generated in livers of alcohol-fed rats can impair the activities of many SAM-dependent methyltransferases. One such methyltransferase is guanidinoa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23c015edce39c75422a0c48d467be03
https://doi.org/10.1111/acer.12306
https://doi.org/10.1111/acer.12306
Autor:
James L. Wisecarver, Benita L. McVicker, Kusum K. Kharbanda, Shannon M. Bailey, Natalia A. Osna, Sandra L. Todero, Dean J. Tuma, Adrienne L. King
Publikováno v:
International Journal of Hepatology
International Journal of Hepatology, Vol 2012 (2012)
International Journal of Hepatology, Vol 2012 (2012)
Introduction. Mitochondrial damage and disruption in oxidative phosphorylation contributes to the pathogenesis of alcoholic liver injury. Herein, we tested the hypothesis that the hepatoprotective actions of betaine against alcoholic liver injury occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbc90370fca3dd31e052c970f3e08f6
https://doi.org/10.1155/2012/962183
https://doi.org/10.1155/2012/962183
Autor:
Nash P. Whitaker, Sandra L. Todero, Terrence M. Donohue, John S. Davis, Natalia A. Osna, Casey S. Trambly, Paul G. Thomes
Publikováno v:
Alcoholism: Clinical and Experimental Research. 36:759-767
Background Previous work demonstrated that the transcription factor, early growth response-1 (Egr-1) participates in the development of steatosis (fatty liver) after chronic ethanol administration. Here, we determined the extent to which Egr-1 is inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e0ef2c7bc30c9c4bf6e1cdc479538a
https://doi.org/10.1111/j.1530-0277.2011.01681.x
https://doi.org/10.1111/j.1530-0277.2011.01681.x
Publikováno v:
Molecular and Cellular Biochemistry. 327:75-78
Our previous studies, demonstrating ethanol-induced alterations in phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine methyltransferase (PEMT) pathway, implicated a defect in very low-density lipoprotein (VLDL) secretion in the patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3b6cabaecec8c7d5d5d4894f1944b4
https://doi.org/10.1007/s11010-009-0044-2
https://doi.org/10.1007/s11010-009-0044-2
Autor:
Amin A. Nanji, Tiana V. Curry-Mccoy, Kusum K. Kharbanda, Terrence M. Donohue, Natalia A. Osna, Ronda L. White, Sandra L. Todero
Publikováno v:
Alcoholism: Clinical and Experimental Research. 31:1053-1060
Background: l-Buthionine (S,R) sulfoximine (BSO) is an inhibitor of glutathione biosynthesis and has been used as an effective means of depleting glutathione from cells and tissues. Here we investigated whether treatment with BSO enhanced ethanol-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0514a08b5e4f460fd4743a9b600352a
https://doi.org/10.1111/j.1530-0277.2007.00393.x
https://doi.org/10.1111/j.1530-0277.2007.00393.x
Autor:
Michael F. Sorrell, Pamela L. Tuma, Benita L. McVicker, Courtney S. Schaffert, Dean J. Tuma, Sandra L. Todero
Publikováno v:
Biochemical Pharmacology. 67:2167-2174
A potential in vitro model for studying the mechanisms of alcohol-induced hepatocyte injury is the WIF-B cell line. It has many hepatocyte-like features, including a differentiated, polarized phenotype resulting in formation of bile canaliculi. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad8232cbf92189ea350c374fce29741
https://doi.org/10.1016/j.bcp.2004.01.022
https://doi.org/10.1016/j.bcp.2004.01.022
Publikováno v:
Alcohol. 25:123-128
Findings obtained from our recent studies have demonstrated that malondialdehyde, a product of lipid peroxidation, and acetaldehyde can react together with proteins in a synergistic manner and form hybrid protein conjugates, which have been designate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bc48708c53abf1e56f08492efd5d9e
https://doi.org/10.1016/s0741-8329(01)00174-4
https://doi.org/10.1016/s0741-8329(01)00174-4
Autor:
Terrence M, Donohue, Natalia A, Osna, Casey S, Trambly, Nash P, Whitaker, Paul G, Thomes, Sandra L, Todero, John S, Davis
Publikováno v:
Alcoholism, clinical and experimental research. 36(5)
Previous work demonstrated that the transcription factor, early growth response-1 (Egr-1), participates in the development of steatosis (fatty liver) after chronic ethanol (EtOH) administration. Here, we determined the extent to which Egr-1 is involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a9768e3b3f3fdd52de935599fbcd6cdc
https://pubmed.ncbi.nlm.nih.gov/22141421
https://pubmed.ncbi.nlm.nih.gov/22141421