Výsledky vyhledávání - "Sandra L. Quinlan"

Selection of an Enantioselective Process for the Preparation of a CGRP Receptor Inhibitor

Autor: Qi Gao, Justin B. Sausker, Reising Nathan, Ronald L. Hanson, Chung-Pin H. Chen, Jun Li, Dong Lin, Yadagiri Pendri, Daniel Hsieh, Xuebao Wang, Brenda Remy, William A. Nugent, R. Brent Nielsen, Sandra L. Quinlan, William L. Parker, Rodney L. Parsons, Reginald O. Cann

Publikováno v: Organic Process Research & Development. 16:1953-1966

(R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazine-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (1) is a potent calcitonin gene-related peptide (CGRP) receptor antagonist. We have develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b019a918172e9d9833096efb357b89d
https://doi.org/10.1021/op3003097

Zobrazit plný text záznamu

Independent Synthesis and Fate Studies of Impurities in Process Intermediates of the Anti-AIDS Drug d4T

Autor: Jayachandra P. Reddy, J. Gregory Reid, and Bang-Chi Chen, Qi Gao, Sandra L. Quinlan, Derron R. Stark, Douglas G. Weaver, Deborah A. Renner

Publikováno v: Organic Process Research & Development. 2:203-207

Impurities in isolated intermediates in a process to prepare d4T were identified, independently synthesized, and then taken through the process to determine their ultimate fate. Some of the product...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d78ab183050c25ad172f4bce606ab00
https://doi.org/10.1021/op970126p

Zobrazit plný text záznamu

Regio- and stereoselective ring opening of epoxide with cyanoguanidine dianions, a facile synthesis of the KATP opener BMS-180448

Autor: Gary D. Madding, Bang-Chi Chen, J. Gregory Reid, Tonya P Robinson, Michael J. Humora, William Early, Sandra L. Quinlan, John J. Venit, Edward J. Delaney, Paul A. Jass, William J. Winter

Publikováno v: Tetrahedron: Asymmetry. 9:1337-1340

BMS-180448, (3S,4R)- 2 , was prepared in 63% yield via a facile method which involved a new regio- and stereoselective ring opening of epoxide (3S,4S)- 12 with the potassium dianion of cyanoguanidine 11 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb3443a42e03bc6d36c91c2e715a38a1
https://doi.org/10.1016/s0957-4166(98)00116-5

Zobrazit plný text záznamu

A new thymine free synthesis of the anti-AIDS drug d4T via regio/stereo controlled β-elimination of bromoacetates

Autor: Sandra L. Quinlan, Richard H. Spector, Bang-Chi Chen, J. Gregory Reid

Publikováno v: Tetrahedron Letters. 39:729-732

The anti-AIDS drug d4T was prepared without contamination of the nucleoside bond cleaved by-product thymine from the readily available ribonucleoside 5-methyluridine (1). This was accomplished by using a new strategy which involved a regio/stereo con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a07811600e471d7135d4ea7281746f1
https://doi.org/10.1016/s0040-4039(97)01084-8

Zobrazit plný text záznamu

An Efficient Fischer Indole Synthesis of Avitriptan, a Potent 5-HT1D Receptor Agonist

Autor: John K. Thottathil and, and Sandra L. Quinlan, Derron R. Stark, Brodfuehrer Paul R, Bang-Chi Chen, J. Gregory Reid, Smith Patrick R, Jayachandra P. Reddy, Shaopeng Wang, Thomas R. Sattelberg

Publikováno v: The Journal of Organic Chemistry. 62:9192-9202

An efficient synthesis of the antimigraine drug candidate avitriptan (1, BMS 180048) is reported. The key step is a two-phase Fischer indolization reaction between hydrazine 6 and 5-chlorovaleraldehyde, 20, to give the chloropropylindole 35, which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb0e2d61ff090f280d3b9806a54748a6
https://doi.org/10.1021/jo971368q

Zobrazit plný text záznamu

5′-Benzoyl-2′α-bromo-3′-O-methanesulfonylthymidine: A superior nucleoside for the synthesis of the anti-AIDS drug D4T (Stavudine)

Autor: Jacqueline G. George, Derron R. Stark, Saibaba Racha, Bang-Chi Chen, Steve P. Brundidge, J. Gregory Reid, Sandra L. Quinlan, Vicki H. Audia, Emerich Eisenreich, Richard H. Spector

Publikováno v: Tetrahedron Letters. 36:7957-7960

Summary The anti-AIDS drug d4T is prepared in 75% overall yield starting from the readily available ribonucleoside 5-methyluridine (1). The key step in this new synthesis is the zinc-induced reductive elimination of the bromomesylate 4, which affords

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5eb11457ab5880f94123200dfbab1d8c
https://doi.org/10.1016/0040-4039(95)01752-4

Zobrazit plný text záznamu

Synthesis of a Serinamide by Aminolysis of an N-Unsubstituted α-Amino Ester

Autor: Joan F. Njegovan, Bang-Chi Chen, J. Gregory Reid, Derron R. Stark, and Sandra L. Quinlan, and Barry Pickup, Brian Harrison, Ann-Marie Reynolds

Publikováno v: Organic Process Research & Development. 1:174-175

l-2-Amino-3-hydroxy-N-pentylpropanamide (1) was readily prepared and isolated as its oxalate salt in 81% yield and >99% ee through a “one-pot” process from l-serine methyl ester (4).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6043959811b65d948373957cc2268f37
https://doi.org/10.1021/op960044l

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání