Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Sandra L. Marcus"'
Autor:
Jaclyn M. Winter, John C. Vederas, Sandra L. Marcus, Gareth R. Lambkin, Rachel V. K. Cochrane, Wei Xu, Yi Tang, Zhizeng Gao
Publikováno v:
ChemBioChem. 16:2479-2483
Iterative type I polyketide synthases (PKSs) from fungi are multifunctional enzymes that use their active sites repeatedly in a highly ordered sequence to assemble complex natural products. A phytotoxic macrolide with anticancer properties, 10,11-deh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebd92b115ebf12e92b4f086dd8e5c26
https://doi.org/10.1002/cbic.201500428
https://doi.org/10.1002/cbic.201500428
Autor:
Sandra L. Marcus, John C. Vederas, Dae-Kyun Ro, Joseph N. Roberts, Gillian MacNevin, Jorge Barriuso, Jesse W.-H. Li, Don Trinh Nguyen, Jennifer L. Chaytor
Publikováno v:
Journal of the American Chemical Society. 133:8078-8081
Lovastatin, a cyclic nonaketide from Aspergillus terreus, is a hypercholesterolemic agent and a precursor to simvastatin, a semi-synthetic cholesterol-lowering drug. The biosynthesis of the lovastatin backbone (dihydromonacolin L) and the final 2-met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df026ec1ff103364a4f717c6b8d7ab68
https://doi.org/10.1021/ja201138v
https://doi.org/10.1021/ja201138v
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:603-612
A panel of glycosylated DNA binding agents (1-12) designed as functional anthracycline mimics was screened against three solid-tumor cell lines (MCF-7, HT 29 and HepG2/C3A) and three non-tumor cell lines by the MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d09573133cac60666300190794a20d
https://doi.org/10.1016/j.bmc.2010.10.054
https://doi.org/10.1016/j.bmc.2010.10.054
Publikováno v:
Carbohydrate Research. 345:10-22
A series of previously reported amino sugar-functionalized intercalating agents, 3-14, were evaluated in two antibacterial assays (paper disk diffusion and 96-well microdilution) against Bacillus atrophaeus, ATCC 9372 and Escherichia coli, ATCC 47076
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a243216912ef942f4b7db1d432da2f8
https://doi.org/10.1016/j.carres.2009.10.010
https://doi.org/10.1016/j.carres.2009.10.010
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1006-1017
A series of simplified thiomarinol derivatives was prepared by way of catalytic enantioselective inverse electron demand hetero [4+2] cycloaddition/allylboration tandem reaction. As a preliminary evaluation, these analogs were tested for antimicrobia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e131db2972ad3f0a19b21bc11948c8
https://doi.org/10.1016/j.bmc.2008.01.001
https://doi.org/10.1016/j.bmc.2008.01.001
Autor:
Matthew D. Clay, John C. Vederas, M.D. Flegel, Maia M. Cherney, Marco J. van Belkum, Michael N.G. James, N. Watanabe, Michael K. Deyholos, Sandra L. Marcus
Publikováno v:
Journal of Molecular Biology. 371:685-702
The essential biosynthetic pathway to l -Lysine in bacteria and plants is an attractive target for the development of new antibiotics or herbicides because it is absent in humans, who must acquire this amino acid in their diet. Plants use a shortcut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7eb16f5ebad29a85ca763f32cf4a96
https://doi.org/10.1016/j.jmb.2007.05.061
https://doi.org/10.1016/j.jmb.2007.05.061
Publikováno v:
Letters in Organic Chemistry. 1:154-158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27af6b3ae1809a51d27cc7d6fa99028b
https://doi.org/10.2174/1570178043488383
https://doi.org/10.2174/1570178043488383
Autor:
B. Brett Finlay, Andrea Slade, Sergio Grinstein, Christopher M. Yip, Tobias Meyer, Mauricio R. Terebiznik, Sandra L. Marcus, Otilia V. Vieira, William S. Trimble
Publikováno v:
Nature Cell Biology. 4:766-773
Salmonella invades mammalian cells by inducing membrane ruffling and macropinocytosis through actin remodelling. Because phosphoinositides are central to actin assembly, we have studied the dynamics of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d468896c4c2f8dc2ce02dc17829409e
https://doi.org/10.1038/ncb854
https://doi.org/10.1038/ncb854
Autor:
Nina O.L. Seto, Sandra L. Marcus, Monica M. Palcic, Adam Szpacenko, Sonia I. Patenaude, Svetlana N. Borisova, Stephen V. Evans
Publikováno v:
Nature Structural Biology. 9:685-690
The human ABO(H) blood group antigens are produced by specific glycosyltransferase enzymes. An N-acetylgalactosaminyltransferase (GTA) uses a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase (GTB) u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd3430711b96e8db5d09fd1bbce141f
https://doi.org/10.1038/nsb832
https://doi.org/10.1038/nsb832
Autor:
Michela G. Bertero, B. Brett Finlay, Sandra L. Marcus, Cyril M. Kay, Louise Creagh, Daniel Lim, Charles A. Haynes, Natalie C. J. Strynadka, Elizabeth A. Frey, Frank Sicheri, Yu Luo, Markus R. Wenk, Richard A. Pfuetzner
Publikováno v:
Nature Structural Biology. 8:1031-1036
Several Gram-negative bacterial pathogens have evolved a type III secretion system to deliver virulence effector proteins directly into eukaryotic cells, a process essential for disease. This specialized secretion process requires customized chaperon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e639afb1e77c305c68fc65f5775715ae
https://doi.org/10.1038/nsb717
https://doi.org/10.1038/nsb717